Comparison of the frequency of periodontal pathogenic species of diabetics and non‐diabetics and its relation to periodontitis severity, glycemic control and body mass index

Akherati, Mojtaba; Shafaei, Ebrahim; Salehiniya, Hamid; Abbaszadeh, Hamid

doi:10.1002/cre2.453

Cited by 7 publications

(2 citation statements)

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“…Interestingly, having a BMI lower than 30 kg/m 2 was associated with greater Pg abundance, possibly indicating a major contribution of related chronic inflammation to ASCVD, while such pro-inflammatory patterns in subjects with obesity may derive from a more complex scenario that may also include the role of dysfunctional adipose tissue and the related adipokines and pro-inflammatory cytokines [ 31 , 32 ]. In the whole study cohort, BMI, another established ASCVD risk factor, was correlated positively with Pg abundance, in agreement with previous reports [ 33 , 34 ], and it was correlated negatively with Fn abundance.…”

Section: Discussionsupporting

confidence: 92%

Oral Porphyromonas gingivalis and Fusobacterium nucleatum Abundance in Subjects in Primary and Secondary Cardiovascular Prevention, with or without Heterozygous Familial Hypercholesterolemia

et al. 2022

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Background: Low-grade chronic inflammation, promoted by dysbiosis of the gut and oral microbiota, has been shown to contribute to individual susceptibility to atherosclerotic cardiovascular disease (ASCVD). High oral Porphyromonas gingivalis (Pg) and lower Fusobacterium nucleatum (Fn) concentrations have been associated with clinical and experimental atherosclerosis. We assessed oral Pg and Fn abundance in very high-risk patients with previously diagnosed ASCVD, with or without heterozygous familial hypercholesterolemia (HeFH), in subjects with HeFH in primary prevention and in healthy subjects. Methods: In this cross-sectional study, 40 patients with previously diagnosed ASCVD (10 with genetically proven HeFH, and 30 without FH), 26 subjects with HeFH in primary prevention, and 31 healthy subjects were selected to quantify oral Pg and Fn abundance by qPCR and assess oral health status. Results: Compared to healthy subjects, patients with previously diagnosed ASCVD showed greater Pg abundance (1101.3 vs. 192.4, p = 0.03), but similar Fn abundance. HeFH patients with ASCVD had an even greater Pg abundance than did non-HeFH patients and healthy subjects (1770.6 vs. 758.4 vs. 192.4, respectively; p = 0.048). No differences were found in the levels of Pg and Fn abundance in HeFH subjects in primary prevention, as compared to healthy subjects. Conclusions: Greater oral Pg abundance is present in very high-risk patients with previously diagnosed ASCVD, with or without FH, suggesting a potential relationship with CV events. Future studies will assess the predictive value of Pg abundance measurement in ASCVD risk stratification.

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Section: Discussionsupporting

confidence: 92%

Oral Porphyromonas gingivalis and Fusobacterium nucleatum Abundance in Subjects in Primary and Secondary Cardiovascular Prevention, with or without Heterozygous Familial Hypercholesterolemia

et al. 2022

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“…The detection of A. actinomycetemcomitans in whole analyzed samples is in accordance with previous studies reporting a high presence of this microorganism in subjects with both PD and T1D or T2D [ 45 , 46 , 47 ]. Evidence clearly underlines its etiological role in localized aggressive juvenile PD [ 48 ].…”

Section: Discussionsupporting

confidence: 91%

Oral Microbiota in Children and Adolescents with Type 1 Diabetes Mellitus: Novel Insights into the Pathogenesis of Dental and Periodontal Disease

et al. 2023

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The oral microbiota can be influenced by multiple factors, but only a few studies have focused on the role of glycemic control in determining early alterations of oral microbiota and their association with pathogenesis of both periodontitis and caries. The aim of this study is to evaluate the interplay between bacteria composition, oral hygiene, and glycemic control in a cohort of children with T1D. A total of 89 T1D children were enrolled (62% males, mean age: 12.6 ± 2.2 years). Physical and clinical characteristics, glucometabolic parameters, insulin treatment, and oral hygiene habits data were collected. Microbiological analysis was performed from saliva samples. A high prevalence of cariogenic and periodontopathogens bacteria in our cohort was detected. In particular, in all subjects Actinomyces spp., Aggregatibacter actinomycetemcomitans, Prevotella intermedia, and Lactobacillus spp. were isolated. S. mutans was found in about half of the analyzed sample (49.4%), in particular in patients with imbalance values of glycemic control. Moreover, a higher presence of both S. mutans and Veillonella spp. was detected in subjects with poorer glycemic control, in terms of HbA1c, %TIR and %TAR, even adjusting for age, sex, and hygiene habits as covariates. Virtuous oral hygiene habits, such as frequency of toothbrush changes and professional oral hygiene, negatively correlated with the simultaneous presence of Tannerella forsythia, Treponema denticola, and Porphyromonas gingivalis, red complex bacteria. Our study shows it is crucial to pay attention to glycemic control and regular oral hygiene to prevent the establishment of an oral microbiota predisposing to dental and periodontal pathology in subjects with T1D since childhood.

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Comparison of the frequency of periodontal pathogenic species of diabetics and non‐diabetics and its relation to periodontitis severity, glycemic control and body mass index

Akherati

Shafaei

Salehiniya

et al. 2021

Clinical & Exp Dental Res

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Objectives: To investigate common pathogenic bacteria of periodontal diseases (PD) in patients with type 2 diabetes mellitus (T2DM) and its relationship with PD severity, glycemic control and body mass index (BMI).Material and Methods: This case-control study consisted of 55 patients with T2DM and 55 individuals as control. Samples were collected from periodontal pockets. After DNA extraction, using 16srRNA-specific primers, the presence of Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf), Prevotella intermedia (Pi), and Fusobacterium nucleatum (Fn) were examined based on polymerase chain reaction method.Results: Aa frequency was significantly higher in in T2DM group than control. There were no significant differences in the frequencies of Pg, Tf, Pi, and Fn between studied groups. There were no significant differences between frequencies of studied bacteria in different severities of periodontitis in T2DM group. Prevalence of Tf in T2DM patients with moderate periodontitis was significantly higher than non-diabetics with moderate periodontitis. There was no significant difference between the frequency of bacteria in diabetics with good and poor glycemic control. There was a significant difference between the frequencies of Pg in T2DM individuals with different BMI levels.Conclusions: A higher frequency of detection of Aa was found in diabetic when compared to non-diabetics. Glycemic control did not affect the frequency distribution of studied bacteria in T2DM. Pg was identified in higher frequency in overweight T2DM patients.bacteria, body mass index, diabetes mellitus, periodontal disease, periodontal index | INTRODUCTIONPeriodontal disease (PD) is an inflammatory and infectious disease of the supporting tissues around the tooth, which originates from microbial plaque-derived product and occurs due to a specific and complex interaction between pathogenic bacteria and the host response (D'Cruz, 2020).Diabetes mellitus (DM) refers to a group of metabolic diseases that result from any defect in insulin secretion, insulin action, or both. Type 2 diabetes mellitus (T2DM) often develops as a result of

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Comparison of the frequency of periodontal pathogenic species of diabetics and non‐diabetics and its relation to periodontitis severity, glycemic control and body mass index

Cited by 7 publications

References 23 publications

Oral Porphyromonas gingivalis and Fusobacterium nucleatum Abundance in Subjects in Primary and Secondary Cardiovascular Prevention, with or without Heterozygous Familial Hypercholesterolemia

Oral Porphyromonas gingivalis and Fusobacterium nucleatum Abundance in Subjects in Primary and Secondary Cardiovascular Prevention, with or without Heterozygous Familial Hypercholesterolemia

Oral Microbiota in Children and Adolescents with Type 1 Diabetes Mellitus: Novel Insights into the Pathogenesis of Dental and Periodontal Disease

Comparison of the frequency of periodontal pathogenic species of diabetics and non‐diabetics and its relation to periodontitis severity, glycemic control and body mass index

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