Comparison of the histopathological characteristics of osteomyelitis, medication-related osteonecrosis of the jaw, and osteoradionecrosis

Shuster, Amir; Reiser, Vadim; Trejo, Leonor; Ianculovici, Clariel; Kleinman, Shlomi; Kaplan, Ilana

doi:10.1016/j.ijom.2018.07.002

Cited by 51 publications

(50 citation statements)

References 23 publications

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“…The evolution of SSI was classified according to the following categories: complete recovery, plate loosening or pain requiring hardware removal, and long-term complications (osteomyelitis or pseudarthrosis). The diagnosis of osteomyelitis was based on clinical history, sampling of the bone and histopathological characteristics 13 .…”

Section: Methodsmentioning

confidence: 99%

Severity and long-term complications of surgical site infections after orthognathic surgery: a retrospective study

Cousin

Boulétreau

Giai

et al. 2020

Sci Rep

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Surgical site infections (SSI) occur in 1.4% to 33.4% of cases after orthognathic surgery. This type of complication is a major concern to surgical teams, but there is no consensus for the prevention and treatment of SSI in orthognathic surgery. The purpose of this descriptive study was to evaluate the severity and the consequences of postoperative infections. The charts of all the patients operated on by the orthognathic surgery team between January 2015 and July 2017 were collected. All types of orthognathic procedures (Le Fort I maxillary osteotomy, bilateral sagittal split mandibular osteotomy, and genioplasty) were screened, and patients diagnosed with SSI were included. Demographic data, timing and severity of the infection, as well as long-term complications were recorded. Five hundred and twelve patients were screened. Forty-one patients (8%) presenting with SSI were included. There were 18 men and 23 women. The site of the infection was mandibular for 38 patients (92.7%) and maxillary for 3 patients (7.3%). The average time between surgery and infection was 31.5 days. Twenty-four patients received isolated oral antibiotics for inflammatory cellulitic reaction (58.8%), 15 patients had a localized collection treated by incision and drainage under local anesthesia (36.6%), and 2 patients had an extensive collection requiring surgical drainage under general anesthesia (4.9%). Five patients (12.2%) needed hardware removal for plate loosening, and 2 patients (4.9%) developed chronic osteomyelitis. Infection following orthognathic surgery is easily treated most of the time with no long-term complications. In cases of patients with potential risk factors for severe infection, antibiotics may be given with curative intents.

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Section: Methodsmentioning

confidence: 99%

Severity and long-term complications of surgical site infections after orthognathic surgery: a retrospective study

Cousin

Boulétreau

Giai

et al. 2020

Sci Rep

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“…34,36 MRONJ Patogenez MRONJ'un tanımı 10 yılı aşkın bir süre önce yapılmıştır ancak patofizyolojisi henüz tam olarak açıklığa kavuşamamıştır. 38 Enflamasyon veya enfeksiyon uzun zamandır osteonekrozun önemli bir bileşeni olarak kabul edilmekte ve yapılan çalışmalar nekrotik kemik örneklerinde bakterileri, özellikle Aktinomiçes türlerini rapor etmiştir. 9,[39][40][41] Aktinomiçesin birçok vakada histolojik bulgu olarak görülmesinden dolayı araştırmacılar bu türün MRONJ'un patogenezinde rol oynadığını savunmaktadır.…”

Section: Mronj'un Radyografik Bulgularıunclassified

“…9,[39][40][41] Aktinomiçesin birçok vakada histolojik bulgu olarak görülmesinden dolayı araştırmacılar bu türün MRONJ'un patogenezinde rol oynadığını savunmaktadır. 38…”

Section: Mronj'un Radyografik Bulgularıunclassified

İlaca Bağli Çene Kemi̇ği̇ Osteonekrozu: Bi̇r Derleme

Ömezli¹,

Ayrancı²,

Torul³

et al. 2021

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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Medication Related Osteonecrosis of the Jawbones: A Review Medication Related Osteonecrosis of the Jaws (MRONJ) is a complication characterized by the appearance of necrotic bone in the maxilla and mandible, resulting from the use of bisphosphonates as well as drugs with antiosteoclastic and antiangiogenic activity. No consensus has been reach regarding the treatment protocol that will prevent the economic and social burden of the patients by providing optimum management of this unique complication which constitutes a serious problem for both physicians and patients. The aim of this review is to present the etiopathology and current treatment strategies of Medication Related Osteonecrosis of the Jaws in the light of the literature.

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“…Osteomyelitis is reported in 9.5% of wisdom tooth removal and when a PRF plug was inserted after extraction, this was significantly reduced to 1% of cases [12]. Histopathological parameters of chronic/suppurative osteomyelitis, medicationrelated osteonecrosis of the jaw (MRONJ), and osteoradionecrosis (ORN) are the same, and for this reason, the use of PRF could be a protective factor in the prevention of MRONJ after dental extractions [13]. Şahin et al [14] assessed that the use of PRF seems to be a good alternative for prevention of MRONJ, promoting a high-rate success of surgery and improving healing with better final results.…”

Section: Introductionmentioning

confidence: 99%

The Role of Platelet-Rich Fibrin (PRF) in the Prevention of Medication-Related Osteonecrosis of the Jaw (MRONJ)

Miranda

Gianfreda

Raffone³

et al. 2021

BioMed Research International

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Dentoalveolar surgery is probably the major risk factor for MRONJ and for other complications following a tooth extraction, especially in patients affected by systemic diseases. The aim of this retrospective study is to evaluate whether a PRF plug inserted in the post extraction socket can prevent the onset of MRONJ. The patients were divided into two groups according to the surgical protocol that included the insertion or not of the PRF following the extraction and all the anamnestic, and clinical data were analyzed. In the control group, 5 patients developed MRONJ (19.23%) while in the study group, any case of MRONJ was reported. In the control group, patients who developed MRONJ had a CTX with less than 100 pg/mL (5 high-risk patients, Spearman’s rank r = .547 , p < .001 ). The use of platelet concentrates in patients with high risk of MRONJ is a user-friendly technique with an excellent cost-benefit ratio in oral surgery.

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Comparison of the histopathological characteristics of osteomyelitis, medication-related osteonecrosis of the jaw, and osteoradionecrosis

Cited by 51 publications

References 23 publications

Severity and long-term complications of surgical site infections after orthognathic surgery: a retrospective study

Severity and long-term complications of surgical site infections after orthognathic surgery: a retrospective study

İlaca Bağli Çene Kemi̇ği̇ Osteonekrozu: Bi̇r Derleme

The Role of Platelet-Rich Fibrin (PRF) in the Prevention of Medication-Related Osteonecrosis of the Jaw (MRONJ)

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