Comparison of the immune response elicited by infectious and inactivated foot-and-mouth disease virus in mice

Piatti, P. G.; Berinstein, Analía; Lopez, Osvaldo J.; Borca, Manuel V.; Fernandez, F.; Schudel, Alejandro A.; Sadir, A.M.

doi:10.1099/0022-1317-72-7-1691

Cited by 19 publications

(9 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Significant difference in the serum antibody titres after 21 days of vaccination (1/16th dose) and that of infection revealed the importance of antigen mass in vaccine to optimally stimulate the protective immune response as reported by previous studies (Piatti et al 1991;Parida et al 2006). The difference between the vaccinated and unvaccinated cattle after infection was not significant.…”

Section: Discussionsupporting

confidence: 60%

Kinetics of immune response to foot-and-mouth disease virus (type Asia 1) in experimental cattle

et al. 2008

View full text Add to dashboard Cite

Humoral and mucosal (secretory antibody)immune response to FMDV type Asia 1 in cattle was analyzed after vaccination and infection using virus neutralizing test (VNT). Vaccination (1/16th the usual dose) failed to protect cattle from generalized clinical disease following experimental FMDV Asia 1 infection. Our results showed that infection induced higher and prolonged serum antibody titres indicating antigen mass is important for optimal immune response. Experimental FMDV infection induced significant secretory antibody (mucosal) response in cattle. Though, there was no difference in the serum antibody response between the cattle that developed generalized infection (unprotected) and those with only localized infection (protected), secretory antibody response differed, wherein the unprotected cattle had higher secretory response than protected cattle. Thus, FMDV Asia 1 infection stimulates a similar serum antibody response and a unique secretory antibody response among the infected cattle.

show abstract

Section: Discussionsupporting

confidence: 60%

Kinetics of immune response to foot-and-mouth disease virus (type Asia 1) in experimental cattle

et al. 2008

View full text Add to dashboard Cite

show abstract

“…in OPF of all infected cattle independent of their 'carrier state' and intermittent virus replication may be required for the second late serum IgA response described in carrier cattle (Parida et al, 2006;Salt et al, 1996). Piatti et al (1991) demonstrated that the duration and magnitude of the immune response in mice immunized intraperitoneally with inactivated virus in PBS correlated directly with the mass of antigen used, and at high antigen doses there was no difference in the immune response elicited or maintenance of SNA titres over 200 days compared with experimental infection. Similar results were reported by Ló pez et al (1990) and Wigdorovitz et al (1997).…”

Section: Duration Of Protective Immunitymentioning

confidence: 99%

Laboratory animal models to study foot-and-mouth disease: a review with emphasis on natural and vaccine-induced immunity

Habiela

Seago

Pérez-Martín

et al. 2014

Journal of General Virology

View full text Add to dashboard Cite

Laboratory animal models have provided valuable insight into foot-and-mouth disease virus (FMDV) pathogenesis in epidemiologically important target species. While not perfect, these models have delivered an accelerated time frame to characterize the immune responses in natural hosts and a platform to evaluate therapeutics and vaccine candidates at a reduced cost. Further expansion of these models in mice has allowed access to genetic mutations not available for target species, providing a powerful and versatile experimental system to interrogate the immune response to FMDV and to target more expensive studies in natural hosts. The purpose of this review is to describe commonly used FMDV infection models in laboratory animals and to cite examples of when these models have failed or successfully provided insight relevant for target species, with an emphasis on natural and vaccine-induced immunity. IntroductionFoot-and-mouth disease virus (FMDV: family Picornaviridae; genus Aphthovirus) is known to naturally infect a wide variety of cloven-hoofed domesticated and wild animal species, causing an acute disease characterized by vesicular lesions of the tongue, snout, buccal cavity, feet and teats (Grubman & Baxt, 2004). Despite causing extensive lesions, the cycle of infection in the individual animal is short, and foot-and-mouth disease (FMD) usually resolves without the need for treatment and is seldom lethal in adults (Arzt et al., 2011b). However, the highly contagious nature, wide dissemination and significant economic impact of FMD have made it one of the most feared livestock diseases and a major research focus for more than a century. Progress towards the development of effective tools for FMD control has been hampered by several factors including the cost and logistics of largeanimal experimentation in specialized high-containment facilities, incomplete knowledge of the host's immune systems and lack of immunological reagents compared to biomedical rodent species and humans. These factors delayed the production of vaccines on an industrial scale and this major research goal was subsequently only achieved in the 1950s (Lombard et al., 2007). In a review, Brown (2003) highlighted that this milestone could not have been achieved without certain significant advances in our knowledge of FMD. The first significant advance was the demonstration by Loeffler & Frosch (1897) that the disease was caused by a virus and the second was the establishment of FMD laboratory animal models, including the guinea-pig model (Waldman & Pape, 1920) followed by the suckling mouse model (Skinner, 1951). Although not without their flaws, these FMD laboratory animal models have helped elucidate several mechanisms of FMD pathogenesis, which would have been difficult to achieve directly in target species. These models have provided an accelerated time frame at significantly reduced costs to develop and test vaccine candidates and continue to be a useful tool for interrogating FMDV immune responses. However, we now know that porcine and ru...

show abstract

“…Only with a fully active phagocytic system can an efficient pro-tective immune response against FMD virus be seen (17,19). This could explain why low levels of specific antibody can be effective in protecting animals against FMD (14,17,20,25,26,29,30,32). The conclusion from the work on phagocytosis (17, 19) was that the major arm of the protective immune response against FMD virus was effected through opsonization of virus by antibody, resulting in augmented phagocytosis by cells of the reticuloendothelial system.…”

Section: Protectwve Immune Response Against Fmd Virusmentioning

confidence: 99%

Protective immune response against foot-and-mouth disease

McCullough¹,

Simone²,

Brocchi³

et al. 1992

J Virol

197

View full text Add to dashboard Cite

The causative agents of foot-and-mouth disease (FMD) are small icosahedral viruses of theAphthovirus group within the Picornaviridae family. There is no evidence that these viruses infect cells of the immune system or otherwise interfere detrimentally with their function; additionally, it has not been possible to relate cytotoxicity reactions against virus-infected cells to the efficacy of the immune response against FMD virus infection. In contrast, there is a close association between FMD virus antibody and the protective immune response (10, 14, 15, 20, 24, 25, 29-32). Induction of this antibody is dependent on the structure of the viral antigenic sites (7-9, 11, 18) and on the concomitant presence of Tb-lymphocyte epitopes (4, 5, 7, 8), although a Ti-lymphocyteindependent response has been reported (2). Recent work by Piatti et al. (26) showed that the immune response induced by FMD virus was only Th-lymphocyte dependent when low doses of antigen were used. This latter

show abstract

Comparison of the immune response elicited by infectious and inactivated foot-and-mouth disease virus in mice

Cited by 19 publications

References 6 publications

Kinetics of immune response to foot-and-mouth disease virus (type Asia 1) in experimental cattle

Kinetics of immune response to foot-and-mouth disease virus (type Asia 1) in experimental cattle

Laboratory animal models to study foot-and-mouth disease: a review with emphasis on natural and vaccine-induced immunity

Protective immune response against foot-and-mouth disease

Contact Info

Product

Resources

About