“…the most abundant chemical compounds generated during HTP use were glycerol, menthol, nicotine, propylene glycol, and acetol [34,35] to compare the environmental pollution generated by e-cigarettes, IQOS, and traditional cigarettes, in a standard indoor environment the characterization of black carbon, metal particles, organic compounds, and the size-segregated particle mass, and the concentrations emitted from IQOS; a room 48 m 2 ; 13 smoking/ vaping sessions: an e-cigarette (16 mg/ml nicotine, 1 puff every min for 7 min, followed by 3 min pause), IQOS (with 10 menthol and 14 without menthol IQOS sticks, 3-h smoking session, average smoking time -7 min, followed by a short 3-min pause), conventional cigarette (9 cigarette per each session, average smoking time -7 min, followed by a short 3-min pause) -the IQOS side-stream smoke indicated that the particulate emission of organic matter from these devices is significantly different, depending on the organic compound -IQOS smoke was mostly free from aromatic hydrocarbons (PAHs) -IQOS use still emitted substantial levels (up to 2-6 mg/h during a regular smoking regimen) of certain n-alkanes, organic acids (such as suberic acid, azelaic acid, and n-alkanoic acids with carbon numbers [10][11][12][13][14][15][16][17][18][19] and levoglucosan compared to both e-cigarettes and conventional cigarettes, metal emissions were reduced in IQOS smoke, and these emissions were mostly similar to the background levels [14] PMI to assess the impact of THS2.2 use on indoor air quality THS2.2 and a widely available tobacco cigarette, an environmentally controlled room, 3 scenarios: "Office," "Residential" and "Hospitality;"…”