Comparison of the Intraosseous Biocompatibility of AH Plus, EndoREZ, and Epiphany Root Canal Sealers

Sousa, Cássio José Alves de; Montes, Cristiana R.M.; Pascon, Elizeu A.; Loyola, A.M.; Versiani, Marco Aurélio

doi:10.1016/j.joen.2005.12.003

Cited by 116 publications

(135 citation statements)

References 23 publications

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“…In a study comparing the intraosseous biocompatibility of Epiphany materials (endodontic sealer with the same chemical composition as RealSeal) and AH Plus materials for 4-and 12-week intervals, Sousa et al [15] observed that, in the presence of AH Plus, the inflammatory reaction decreased from severe to moderate, while in the presence of Epiphany it was reduced or even became absent.…”

Section: Discussionmentioning

confidence: 99%

The influence of three endodontic sealers on bone healing: an experimental study

et al. 2016

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Section: Discussionmentioning

confidence: 99%

The influence of three endodontic sealers on bone healing: an experimental study

et al. 2016

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“…Unfortunately, several studies have shown that most commercially available materials can cause mild to severe inflammatory changes in apical tissues, leading to bone destruction [21][22][23][24]. Endodontic sealants may also affect periradiculare tissues by direct contact in cases of overfilling or extracted components.…”

Section: Discussionmentioning

confidence: 99%

“…Endodontic sealants may also affect periradiculare tissues by direct contact in cases of overfilling or extracted components. They can be released into the surrounding tissues by the dentin tube and channels from the apical level [21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Testing endodontic sealers on human umbilical vein endothelial cells

et al. 2013

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AbstractThe toxic potential of the endodontic sealers ingredients, especially the unreacted monomer, that can irritate the periapical tissue and interfere with the healing process, thus having a negative impact on the biocompatibility of the material. The aim of this study was to evaluate the influence of three experimental endodontic sealers on cells viability in vitro. Human umbilical vein endothelial cells (HUVEC) were used. The experiments were done with solid samples and extracts of sealers in artificial saliva and water. The experiments evaluated the cytotoxicity of the residual monomers that resulted from the tested composites. The decrease in cell viability was quantified by colorimetric measurement of formazan. The components of the sealers dissolved in artificial saliva and water were determined by high performance liquid chromatography (HPLC). The HUVEC are a novelty for testing the endodontic sealers biocompatibility, with certain advantages compared to other cell types used in the literature, e.g. HELA cells, fibroblasts. The data showed that cytotoxicity was directly linked with the unreacted monomer — 2-hydroxyethyl methacrylate (HEMA) present in these composites. Two of the three formulations had little or no cytotoxic effect, which makes them suitable for further testing in order to be used in endodontic treatment.

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“…The biocompatibility of methacrylate resinbased Epiphany SE and epoxy resin-based AH Plus Jet has been evaluated. First-generation Epiphany was shown to induce bone formation and cause a slight osseous inflammatory reaction in the in vivo experiment 8) . The in vitro experiments demonstrated that Epiphany in freshly mixed or set conditions showed severe-to-moderate cytotoxicity 9) , and its cytotoxicity increased with time, posing significant risks 10,11) .…”

Section: Introductionmentioning

confidence: 99%

“…AI-Hiyasat et al showed that AH Plus was the most biocompatible material in mouse fibroblasts for 48 h according to the MTT assay ([3-4,5-Dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) 18) . Furthermore, the intraosseous implantation of endodontic materials into the tibia 8) and the application of RCSs have been carried out on large animals such as dogs 19,20) . These in vivo studies demonstrated that AH Plus has a biologic potential.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the biocompatibility of resin-based root canal sealers in rat periapical tissue

et al. 2013

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We evaluated the biocompatibility of resin-based root canal sealers (RCSs) in the periapical tissues of rats. Wistar rats underwent tooth replantation for reproducing the response of periapical tissue with RCSs. The resin-based Epipany SE™, AH Plus Jet™, the eugenol-based sealer (Canals) and a control group were employed. The upper right first molar was extracted and applied with RCSs on apices, and then the tooth was repositioned. Histological evaluation demonstrated that mild inflammation occurred in the periapical tissue with Epiphany and AH Plus Jet sealers on day 7, whereas Canals induced severe-to-moderate inflammation. The statistical analyses demonstrated that the significant differences were observed between Canals and the other groups on day 7 regarding inflammatory response. On day 14, the lesions induced by all sealers were healed and replaced predominantly by fibrous connective tissue. Our results suggest that Epiphany SE and AH Plus Jet are good biocompatible materials.

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Comparison of the Intraosseous Biocompatibility of AH Plus, EndoREZ, and Epiphany Root Canal Sealers

Cited by 116 publications

References 23 publications

The influence of three endodontic sealers on bone healing: an experimental study

The influence of three endodontic sealers on bone healing: an experimental study

Testing endodontic sealers on human umbilical vein endothelial cells

Evaluation of the biocompatibility of resin-based root canal sealers in rat periapical tissue

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