2016
DOI: 10.1186/s12885-016-2430-y
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Comparison of the miRNA profiles in HPV-positive and HPV-negative tonsillar tumors and a model system of human keratinocyte clones

Abstract: BackgroundBetter insights into the molecular changes involved in virus-associated and -independent head and neck cancer may advance our knowledge of HNC carcinogenesis and identify critical disease biomarkers. Here we aimed to characterize the expression profiles in a matched set of well-characterized HPV-dependent and HPV-independent tonsillar tumors and equivalent immortalized keratinocyte clones to define potential and clinically relevant biomarkers of HNC of different etiology.MethodsFresh frozen tonsillar… Show more

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Cited by 33 publications
(28 citation statements)
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“…Overexpression of miR-15b-5p has previously been associated with HPV-induced malignancies including cervical cancer, tonsillar tumors, and anal carcinomas [ 40 , 41 ]. Moreover, miR-15b-5p was shown to promote cell viability, migration, and invasion in non-small cell lung cancer by targeting metastasis suppressor TIMP2 [ 42 ].…”
Section: Discussionmentioning
confidence: 99%
“…Overexpression of miR-15b-5p has previously been associated with HPV-induced malignancies including cervical cancer, tonsillar tumors, and anal carcinomas [ 40 , 41 ]. Moreover, miR-15b-5p was shown to promote cell viability, migration, and invasion in non-small cell lung cancer by targeting metastasis suppressor TIMP2 [ 42 ].…”
Section: Discussionmentioning
confidence: 99%
“…High-risk HPV infection leads to aberrant expression of cellular oncogenic and tumor suppressive miRNAs. 47 Many researchers have focused on the occurrence of epigenetic phenomena in OSCC development 48 Epigenetic changes represent an important mechanism for the silencing of tumor suppressor genes. 49 Further miRNA genes are subject to epigenetic changes.…”
Section: Oropharyngeal Cancer and Mirnasmentioning
confidence: 99%
“…Furthermore, miR-133a-3p has been noted as a tumor suppressor miRNA downregulated in several cancers including HNSCC tumors and also known to target EGFR [ 31 34 ]. In bladder cancer downregulated miR-133a-3p was reported to serve as a potential biomarker for bladder cancer progression [ 35 , 36 ].…”
Section: Discussionmentioning
confidence: 99%