Comparison of the ovine and porcine animal models for biocompatibility testing of vascular prostheses

Ueberrueck, Torsten; Tautenhahn, J.; Meyer, L.; Kaufmann, O.; Lippert, H.; Gastinger, I.; Wahlers, T

doi:10.1016/j.jss.2004.10.021

Cited by 24 publications

(20 citation statements)

References 27 publications

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“…Suture controls displayed an obvious cleft where the vascular stumps had been re-approximated and the elastic lamina had failed to repair but was otherwise intact. Ueberrueck et al [26] describe the discontinuous endothelialization and formation of neointima in sheep as closely resembling the situation in humans and we consider these results to be a good prediction of potential clinical outcome, although a more thorough study would be required prior to any clinical trial in medium sized vessels.…”

Section: Discussionsupporting

confidence: 58%

“…The ovine carotid model was chosen due to its size and vascular anatomy, as well as ease of surgical access and historical use as a model for the development of IH [24,25]. In addition, sheep have been used to assess the biocompatibility of vascular prostheses out to 3 months, displaying a coagulative system and neointimal formation that closely approximates humans [26].…”

Section: Discussionmentioning

confidence: 99%

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Laser‐assisted end‐to‐end bioweld^® anastomosis in an ovine model

Wright¹,

Vicaretti

Schwaiger³

et al. 2007

Lasers Surg Med

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The BioWeld tube, an albumin-based exovascular stent, has been used for microsurgical anastomoses and compared to conventional sutures. The study presented investigated the potential of the BioWeld tube for vascular anastomosis in larger vessels. Laser-assisted BioWeld anastomoses were compared to conventional-sutured anatomoses of the carotid artery of Merino-x ewes. The BioWeld procedure resulted in 100% survival and 100% patency at 1 and 6 week post-operative periods, with no noticeable foreign body response. Sutured animals showed 100% survival and patency. The ischemic time for BioWeld anastomosis averaged 15 minutes compared with 10 minutes for sutures. This study indicates that the BioWeld tube is an easy to use anastomotic technique with equivalent success rates and comparable anastomotic times.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Laser‐assisted end‐to‐end bioweld^® anastomosis in an ovine model

Wright¹,

Vicaretti

Schwaiger³

et al. 2007

Lasers Surg Med

View full text Add to dashboard Cite

show abstract

“…Some reports simply state that animals underwent TEV implantation 10-12 . Others report the use of end-to-side 3,5,13,14 , or end-to-end 4,6 anastomosis. Finally, others specifically state the use of interrupted 4 , or continuous running suture 15 .…”

Section: Discussionmentioning

confidence: 99%

“…Currently ultrasonography or angiogram imaging are the only methods used to evaluate the integrity of the TEV in vivo 3,5,6,10-14 . Ultrasound imaging does not typically provide the resolution needed to observe compliance changes of the TEV.…”

Section: Discussionmentioning

confidence: 99%

Surgical Technique for the Implantation of Tissue Engineered Vascular Grafts and Subsequent <em>In Vivo </em>Monitoring

Koobatian

Koenigsknecht

Row

et al. 2015

JoVE

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The development of Tissue Engineered Vessels (TEVs) is advanced by the ability to routinely and effectively implant TEVs (4-5 mm in diameter) into a large animal model. A step by-step protocol for inter-positional placement of the TEV and real-time digital assessment of the TEV and native carotid arteries is described here. In vivo monitoring is made possible by the implantation of flow probes, catheters and ultrasonic crystals (capable of recording dynamic diameter changes of implanted TEVs and native carotid arteries) at the time of surgery. Once implanted, researchers can calculate arterial blood flow patterns, invasive blood pressure and artery diameter yielding parameters such as pulse wave velocity, augmentation index, pulse pressures and compliance. Data acquisition is accomplished using a single computer program for analysis throughout the duration of the experiment. Such invaluable data provides insight into TEV matrix remodeling, its resemblance to native/sham controls and overall TEV performance in vivo.

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“…Taylor et al 115 72 implanted polyester conduits as sheep carotid bypass or pig aortic interposition grafts and assessed IH at 3 months. They found no difference between species, although the differences in anastomotic geometry, animal maturity, and possible size mismatch for these 8-mm-diameter conduits are important uncontrolled confounding factors.…”

Section: Large-animal Models For the Assessment Of Novel Vascular Conmentioning

confidence: 99%

Animal models for the assessment of novel vascular conduits

Byrom

Bannon

White

et al. 2010

Journal of Vascular Surgery

158

132

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The development of an ideal small-diameter conduit for use in vascular bypass surgery has yet to be achieved. The ongoing innovation in biomaterial design generates novel conduits that require preclinical assessment in vivo, and a number of animal models have been used for this purpose. This article examines the rationale behind animal models used in the assessment of small-diameter vascular conduits encompassing the commonly used species: baboons, sheep, pigs, dogs, rabbits, and rodents. Studies on the comparative hematology for these species relative to humans are summarized, and the hydrodynamic values for common implant locations are also compared. The large- and small-animal models are then explored, highlighting the characteristics of each that determine their relative utility in the assessment of vascular conduits. Where possible, the performance of expanded polytetrafluoroethylene is given in each animal and in each location to allow direct comparisons between species. New challenges in animal modeling are outlined for the assessment of tissue-engineered graft designs. Finally, recommendations are given for the selection of animal models for the assessment of future vascular conduits.

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Comparison of the ovine and porcine animal models for biocompatibility testing of vascular prostheses

Cited by 24 publications

References 27 publications

Laser‐assisted end‐to‐end bioweld^® anastomosis in an ovine model

Laser‐assisted end‐to‐end bioweld^® anastomosis in an ovine model

Surgical Technique for the Implantation of Tissue Engineered Vascular Grafts and Subsequent <em>In Vivo </em>Monitoring

Animal models for the assessment of novel vascular conduits

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Comparison of the ovine and porcine animal models for biocompatibility testing of vascular prostheses

Cited by 24 publications

References 27 publications

Laser‐assisted end‐to‐end bioweld® anastomosis in an ovine model

Laser‐assisted end‐to‐end bioweld® anastomosis in an ovine model

Surgical Technique for the Implantation of Tissue Engineered Vascular Grafts and Subsequent <em>In Vivo </em>Monitoring

Animal models for the assessment of novel vascular conduits

Contact Info

Product

Resources

About

Laser‐assisted end‐to‐end bioweld^® anastomosis in an ovine model

Laser‐assisted end‐to‐end bioweld^® anastomosis in an ovine model