Comparison of the Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Between Ischemic Optic Neuropathy and Open–Angle Glaucoma

Fard, Masoud Aghsaei; Afzali, Maryam; Abdi, Parisa; Yasseri, Mehdi; Ebrahimi, Katayoon B.; Moghimi, Sasan

doi:10.1167/iovs.15-18618

Cited by 36 publications

(39 citation statements)

References 24 publications

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“…In this cross-sectional study using spectral-domain OCT (Cirrus; Carl Zeiss Meditec, Dublin, CA, USA), we analysed both sectoral RNFL and sectoral GCIPL in primary open-angle glaucoma (POAG) patients and stabilised, unilateral NAION patients. Similar to our study, Fard et al [ 13 ] compared patterns of GCIPL defects between POAG and NAION using another spectral-domain OCT device (Spectralis; Heidelberg, Jena, Germany). In their study, to match the severity of optic disc damage in NAION, moderate-to-severe POAG cases (mean deviation [MD] on visual field examination < -6.0 dB) were selectively enrolled.…”

Section: Introductionsupporting

confidence: 75%

“…[ 42 ] While papillomacular nerve fibre bundles are spared in this region until a late stage in POAG, they are generally damaged in NAION. [ 13 , 42 , 43 ] The higher incidence of ischaemic events in the superior region in NAION, and less profound damage in the superior region in POAG, may also support this. [ 29 , 34 – 37 , 39 , 40 ] However, in our study, there was no difference in the inferior or inferotemporal GCIPL sectors between NAION and POAG.…”

Section: Discussionmentioning

confidence: 97%

“…[ 6 – 8 ] Similar to glaucoma, NAION also results in significant axonal and ganglion cell loss. [ 9 – 13 ] However, unlike glaucoma, NAION does not progress chronologically and to date there is no effective treatment strategy, so there is no need for exhaustive care (except management of vascular risk factors to prevent NAION occurring in the fellow eye). [ 14 ] Consequently, in patients with NAION, it is important to prevent unnecessary overtreatment that could result from misdiagnosis of NAION as glaucoma.…”

Section: Introductionmentioning

confidence: 99%

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Difference in patterns of retinal ganglion cell damage between primary open-angle glaucoma and non-arteritic anterior ischaemic optic neuropathy

et al. 2017

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PurposeTo compare the patterns of retinal ganglion cell damage between primary open-angle glaucoma (POAG) and non-arteritic anterior ischaemic optic neuropathy (NAION).MethodsIn total, 35 eyes with unilateral NAION, and 70 age- and average peripapillary retinal nerve fibre layer (RNFL) thickness-matched eyes with POAG, were enrolled as disease groups; 35 unaffected fellow eyes of the NAION, and 70 age- and refractive error-matched normal subjects for the POAG, were enrolled as their control groups, respectively. The peripapillary RNFL thickness and macular ganglion cell plus inner plexiform layer (GCIPL) thickness were compared between the disease groups and their controls, and between the two disease groups.ResultsMean RNFL thicknesses at the 1 and 2 o’clock (superonasal) positions were thinner in NAION than in POAG (both p < 0.05). Mean RNFL thickness at 7 o’clock (inferotemporal) was thinner in POAG than in NAION (p = 0.001). Although there was no significant difference between NAION and POAG in average GCIPL thickness, all of the sectoral GCIPL thicknesses were thinner in NAION (all p < 0.05), except in the inferior and inferotemporal sectors. The ranges of the clock-hour RNFL with damage greater than the average RNFL thickness reduction, versus fellow eyes and control eyes, were 7 hours in NAION and 4 hours in POAG.ConclusionsThe more damaged clock-hour RNFL regions differed between NAION (1 and 2 o’clock) and POAG (7 o’clock). Most sectoral GCIPL thicknesses were thinner in NAION than in POAG.

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Section: Introductionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Difference in patterns of retinal ganglion cell damage between primary open-angle glaucoma and non-arteritic anterior ischaemic optic neuropathy

et al. 2017

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“…14,15 Moderate and severe POAG eyes with Humphrey 24-2 mean deviation of less than -6 dB were recruited, so that the glaucoma and NAION groups would be similar in terms of severity. 1,14,15 Presence or absence of peripapillary atrophy was not an inclusion or exclusion criterion.…”

Section: Methodsmentioning

confidence: 99%

Automated Evaluation of Parapapillary Choroidal Microvasculature in Ischemic Optic Neuropathy and Open Angle Glaucoma

Fard

Salabati

Mahmoudzadeh

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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Citation: Aghsaei Fard M, Salabati M, Mahmoudzadeh R, et al. Automated evaluation of parapapillary choroidal microvasculature in ischemic optic neuropathy and open angle glaucoma. Invest Ophthalmol Vis Sci. 2020;61(3):35. https://doi.org/10.1167/iovs.61.3.35 PURPOSE.To determine whether parapapillary choroidal microvasculature (PPCMv) density as measured by optical coherence tomography angiography differs between nonarteritic anterior ischemic optic neuropathy (NAION) and primary open angle glaucoma (POAG). METHODS.Thirty-seven eyes with chronic NAION, 34 unaffected fellow eyes with NAION, 47 moderate and severe POAG eyes, and 54 healthy control subjects were evaluated. Automated PPCMv density was calculated using custom Matlab software in inner and outer annuli around the optic nerve region in addition to peripapillary superficial retinal vessels. RESULTS.Linear models showed no difference in peripapillary retinal nerve fiber layer between NAION and POAG eyes. Mean peripapillary superficial small vessels in the NAION and POAG groups were 36.62 ± 7.1% and 39.72 ± 8.18% without a statistically difference between them (P = 0.16). Mean inner and outer annular region PPCMv densities in the NAION group were 26.55 ± 9.2% and 17.81 ± 6.9%, which were not different from unaffected fellow eyes and the control group. However, the POAG group had significantly reduced PPCMv density in both inner and outer annuli with values of 15.84 ± 6.5% and 12.80 ± 5.0%, respectively, compared with normal subjects (both P < 0.001). Inner and outer circle PPCMv densities were also significantly reduced in the POAG group compared with the NAION group. CONCLUSIONS. ReducedPPCMv density in POAG eyes shows that deep optic nerve head ocular blood flow may contribute to axonal damage in patients with glaucoma.

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“…The thickening of Gc-IPL in the central 1 mm may be due to intracellular edema due to greater ischemic stress on central fovea in the early phase of NAION and contributes to vision deterioration. Fard et al [27] reported that parafoveal Gc-IPL thinning present in chronic NAION eyes was associated with worse vision compared to glaucoma patients in which central vision is preserved and has no Gc-IPL thinning in this area. Parks et al reported the initial thinning of Gc-IP layer in the macula occurring 46.1 ± 23.2 days after the onset of NAION symptoms.…”

Section: Discussionmentioning

confidence: 99%

Choroidal Thickness in Acute Non-arteritic Anterior Ischemic Optic Neuropathy

Nikkhah

Feizi

Abedi

et al. 2020

JOVR

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Purpose: To compare the choroidal thickness in eyes with acute non-arteritic anterior ischemic optic neuropathy (NAION) with healthy contralateral eye and normal controls. Methods: Thirty-eight eyes with NAION, thirty-eight unaffected fellow eyes, and seventy four eyes from 37 healthy, age- and sex-matched subjects were included in this prospective comparative case-control study. Choroidal thickness was measured by enhanced depth imaging (EDI) of spectral domain optical coherence tomography (SDOCT). Peripapillary choroidal thickness (PCT) was measured at 1000 and 1500 μm from Bruch's membrane opening (BMO). Subfoveal choroidal thickness (SFCT) was measured in central subfoveal area, and 500 microns apart in temporal and nasal sides. Choroidal thickness among NAION eyes, uninvolved fellow eyes, and control eyes were compared. Results: The mean of PCT at 1000 μm was significantly thicker in NAION and fellow eyes compared to control eyes (169.7 ± 47, 154.4 ± 42.1, and 127.7 ± 49.9 μm, respectively, P < 0.001 and P = 0.42). The mean PCT at 1500 μm was also significantly thicker in NAION and fellow eyes compared to control eyes (178.6 ± 52.8, 162.6 ± 46.1, and 135.1 ± 59 μm, respectively, P = 0.007 and P = 0.048). The mean PCT at 1000 and 1500 μm was significantly greater in NAION compared to fellow eyes (P = 0.027 and P = 0.035, respectively). The mean of SFCT was significantly thicker in NAION compared to control eyes (P = 0.032); however, there was no significant difference between uninvolved fellow and control eyes (P = 0.248). Conclusion: Thicker choroidal thickness in acute NAION and uninvolved fellow eyes compared to normal eyes suggests a primary choroidal role in NAION pathophysiology.

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Comparison of the Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Between Ischemic Optic Neuropathy and Open–Angle Glaucoma

Abstract: Patients with NAION show differences in the tissue damage with greater loss of parafoveal GCIPL tissue thickness compared to patients with POAG.

Cited by 36 publications

References 24 publications

Difference in patterns of retinal ganglion cell damage between primary open-angle glaucoma and non-arteritic anterior ischaemic optic neuropathy

Difference in patterns of retinal ganglion cell damage between primary open-angle glaucoma and non-arteritic anterior ischaemic optic neuropathy

Automated Evaluation of Parapapillary Choroidal Microvasculature in Ischemic Optic Neuropathy and Open Angle Glaucoma

Choroidal Thickness in Acute Non-arteritic Anterior Ischemic Optic Neuropathy

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