Comparison of the prognostic value of inflammation-based prognostic scores in patients with hepatocellular carcinoma

Kinoshita, Akiyoshi; Onoda, Hiroshi; Imai, Nami; Iwaku, Akira; Oishi, Mutumi; Fushiya, Nao; Koike, Kazuhiko; Nishino, Hitoo; Tajiri, Hisao

doi:10.1038/bjc.2012.354

Cited by 275 publications

(267 citation statements)

References 25 publications

Supporting

Mentioning

248

Contrasting

Unclassified

Order By: Relevance

“…The NLR and PLR reflect the populations of circulating white cells and platelets and have clinical advantages of being inexpensive and routinely measured in perioperative practice. They are, inferior to some other markers of a cancer-related systemic inflammatory response, such as serum CRP and albumin, the Glasgow prognostic score (GPS) or modified GPS (mGPS) (28,29), but serum CRP levels and other markers are not routinely performed as part of the preoperative assessment of patients. Hence, the NLR and PLR plus the absolute neutrophil, lymphocyte and platelet counts were assessed in patients with thymic carcinoma who were retrospectively evaluated in our study.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of preoperative neutrophil-lymphocyte ratio is superior to platelet-lymphocyte ratio for survival in patients who underwent complete resection of thymic carcinoma

Yuan¹,

Gao²,

Mu³

et al. 2016

J. Thorac. Dis.

View full text Add to dashboard Cite

Background: Preoperative neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) have prognostic value in patients with various operable tumors. The aim of our study was to determine whether NLR and PLR are predictive of survival in thymic carcinoma patients after complete resection. Results: Univariate analysis found that a high level of NLR was associated with lower disease-free survival (DFS) (HR: 3.385, 95% CI: 1.073-10.678, P=0.037) and lower overall survival (OS) (HR: 12.836, 95% CI:1.615-101.990, P=0.016). The optimal NLR threshold of 4.1 could stratify the patients with high risk of recurrence or metastasis (P=0.026) and death (P=0.006). Meanwhile, the NLR value of >4.1 in those patients was associated with bigger tumor size (P=0.035) and more advanced Masaoka stages (P=0.040) compared with NLR ≤4.1. However, the PLR and other variables were not significantly associated with survival in thymic carcinoma patients. Conclusions:The preoperative NLR of >4.1 was significantly associated with larger tumor size, more advanced Masaoka stages and reduced DFS and OS, but was not an independent predictor of survival in thymic carcinoma patients after complete resection.

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic value of preoperative neutrophil-lymphocyte ratio is superior to platelet-lymphocyte ratio for survival in patients who underwent complete resection of thymic carcinoma

Yuan¹,

Gao²,

Mu³

et al. 2016

J. Thorac. Dis.

View full text Add to dashboard Cite

show abstract

“…The SII was defined as follows: SII = platelet count × neutrophil count/lymphocyte count (Hu et al 2014), and an SII ≥ 1,600 × 10 9 /L was considered as the cut-off value. The PNI was calculated as albumin + 5 × lymphocyte and PNI < 45 was considered as abnormal, as described previously (Kinoshita et al 2012).…”

Section: Patientsmentioning

confidence: 99%

“…Recently, several biomarkers and hematological indices representative of systemic inflammatory responses, including the neutrophillymphocyte ratio (NLR), the platelet-lymphocyte ratio (PLR), a combination of platelet count and neutrophil-lymphocyte ratio as systemic immune-inflammation index (SII), the C-reactive protein (CRP) and a combination of albumin and lymphocyte count as the prognostic nutritional index (PNI) that have been associated with poor prognosis in various cancers (Proctor et al 2011;Kinoshita et al 2012;Lee et al 2013;Hu et al 2014;Paramanathan et al 2014). Other hematological indices, including platelet count, hemoglobin (HGB), and the mean corpuscular volume (MCV) have been reported as potential predictors of survival, and have responded to chemotherapeutic agents in a limited number of studies (Dellapasqua et al 2012;Qu et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Systemic Immune-inflammation Index, Based on Platelet Counts and Neutrophil-Lymphocyte Ratio, Is Useful for Predicting Prognosis in Small Cell Lung Cancer

Hong

Cui

Wang

et al. 2015

Tohoku J. Exp. Med.

271

239

View full text Add to dashboard Cite

Small cell lung cancer (SCLC) is an aggressive disease characterized by rapid growth and metastases. It has been recognized that the inflammation of the microenvironment plays a critical role in the development of malignancies. However, little is known about the role of multiple inflammatory and hematological markers in the prognosis of SCLC. The aim of this study was to determine the clinical significance of pre-treatment inflammation-based scores and characteristics as prognostic indicators for the survival of SCLC patients. A retrospective analysis of 919 SCLC cases was performed. Patients' characteristics and hematologic tests data at initial diagnosis were collected. The univariate analysis of all SCLC patients indicated that favorable prognostic factors were age ˂ 70 years, non-smokers, good performance status, limited disease and response to treatment. Moreover, univariate analysis of inflammation-based scores and other blood parameters showed that neutrophil-lymphocyte ratio ≥ 5, platelet-lymphocyte ratio ≥ 250, systemic immune-inflammation index (SII) ≥ 1,600 × 10 9 /L, prognostic nutritional index (albumin + 5 × lymphocyte) < 45, and elevated serum lactate dehydrogenase (LDH) predicted poor prognosis in SCLC patients. SII represents the score that is calculated as follows: platelet count × neutrophil count/lymphocyte count. In the multivariate analysis, SII, together with serum LDH, stage and response to therapy, were associated with overall survival (OS). This study demonstrated that the combination of platelet count and neutrophil-lymphocyte ratio could help to predict poor prognosis in SCLC. Our findings will facilitate the understanding of survival differences in SCLC patients in clinical practice.

show abstract

“…Furthermore, Forrest et al reported that the Glasgow Prognostic Score (GPS), the combination of serum CRP and serum albumin, was a reliable, objective scoring tool for predicting survival rates in patients with inoperable non-small cell lung cancer (9). Additionally, several studies have demonstrated that GPS is associated with prognosis independent of age, stage and performance status in various types of malignancy (10)(11)(12)(13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Glasgow Prognostic Score is superior to ECOG PS as a prognostic factor in patients with gastric cancer with peritoneal seeding

et al. 2018

View full text Add to dashboard Cite

Abstract. The Glasgow Prognostic Score (GPS) has been shown to be associated with survival rates in patients with advanced cancer. The present study aimed to compare the GPS with the Eastern Cooperative Oncology Group Performance Status (ECOG PS) in patients with gastric cancer with peritoneal seeding. For the investigation, a total of 384 gastric patients with peritoneal metastasis were retrospectively analyzed. Patients with elevated C-reactive protein (CRP; >10 mg/l) and hypoalbuminemia (<35 mg/l) were assigned a score of 2. Patients were assigned a score of 1 if presenting with only one of these abnormalities, and a score of 0 if neither of these abnormalities were present. The clinicopathologic characteristics and clinical outcomes of patients with peritoneal seeding were analyzed. The results showed that the median overall survival (OS) of patients in the GPS 0 group was longer, compared with that in the GPS 1 and GPS 2 groups (15.50, vs. 10.07 and 7.97 months, respectively; P<0.001). No significant difference was found between the median OS of patients with a good performance status (ECOG <2) and those with a poor (ECOG ≥2) performance status (13.67, vs. 11.80 months; P= 0.076). In the subgroup analysis, the median OS in the GPS 0 group was significantly longer, compared with that in the GPS 1 and GPS 2 groups, for the patients receiving palliative chemotherapy and patients without palliative chemotherapy. Multivariate survival analysis demonstrated that CA19-9, palliative gastrectomy, first-line chemotherapy and GPS were the prognostic factors predicting OS. In conclusion, the GPS was superior to the subjective assessment of ECOG PS as a prognostic factor in predicting the outcome of gastric cancer with peritoneal seeding.

show abstract

Comparison of the prognostic value of inflammation-based prognostic scores in patients with hepatocellular carcinoma

Cited by 275 publications

References 25 publications

Prognostic value of preoperative neutrophil-lymphocyte ratio is superior to platelet-lymphocyte ratio for survival in patients who underwent complete resection of thymic carcinoma

Prognostic value of preoperative neutrophil-lymphocyte ratio is superior to platelet-lymphocyte ratio for survival in patients who underwent complete resection of thymic carcinoma

Systemic Immune-inflammation Index, Based on Platelet Counts and Neutrophil-Lymphocyte Ratio, Is Useful for Predicting Prognosis in Small Cell Lung Cancer

Glasgow Prognostic Score is superior to ECOG PS as a prognostic factor in patients with gastric cancer with peritoneal seeding

Contact Info

Product

Resources

About