Comparison of the properties of AMVISC® and Healon®

Loftus, Sandra A.; Kuo, Jing-wen; DeVore, Dale P.; Keates, Edwin U.

doi:10.1016/s0886-3350(87)80108-6

Cited by 16 publications

(5 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Figure 5. Synthesis of ethyltridecylcarbodiimide (3) and ethyloctylcarbodiimide (6) and their HA-acylureas 4 and 7. Only N-acylureas were shown, in which R and Ri may be interchanged.…”

Section: Resultsmentioning

confidence: 99%

“…Reactions of the lipophilic carbodiimides with NaHA were carried out in the same way as the EDC-HA reactions described earlier, except that the carbodiimides were R,= -CH2CH2CH2N(CH3)2 in (»), ( 10), (11); -CH2CH3 In (12), ( 13), (14) Figure 6. Synthesis of aromatic carbodiimides 10 and 13, and their HA-acylureas 11 and 14.…”

Section: Resultsmentioning

confidence: 99%

“…1.24-1.74 (10 H), 2.22 (s, 6 H, N(CH3)2, 2.34 (t, J = 7.5 Hz, 2 ), 3.16-3.26 (6 H, -CH2N=C=Nand CH2NHCOO), 5.08 (s, 2 H, benzyl methylene), 7.34 (5 m/e 360 (M+). Ethyltridecylcarbodiimide (3) was prepared as described for carbodiimide 13.…”

Section: (C=0)mentioning

confidence: 99%

“…The purified product gave a negative ninhydrin test result. 1H NMR (D20): 1.08 (t, J = 7.2 Hz, 3 H, CH3CH2N), 1.64 (m, 2 ), 2.18 (s, 6 H, (Ctf)3N), 2.34 (t, J = 7.2 Hz, 2 ), 3.11 (m, 4 H, CH2N). lb: The ratio of 1,6-diaminohexane/EDC was 5/1.…”

Section: (C=0)mentioning

confidence: 99%

“…Sodium hyaluronate (NaHA) is characterized by its large hydrodynamic volume (5). NaHA with a molecular weight of 1 million has an intrinsic viscosity of 3000 mL/g (6). It absorbs water, cushions cells, and lubricates the soft tissues of joints.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Chemical modification of hyaluronic acid by carbodiimides

1991

View full text Add to dashboard Cite

Hyaluronic acid (HA) is a linear polysaccharide with repeating disaccharide units of glucuronic acid and N-acetylglucosamine and is found in the extracellular matrix of connective tissues. Reaction of high molecular weight sodium hyaluronate (NaHA, MW approximately 2 x 10(6] with EDC at pH 4.75, either in the presence or absence of a primary diamine, gave the N-acylurea and O-acylisourea as NaHA-carbodiimide adducts. None of the expected intermolecular coupling with the amine component was observed. On the basis of this new observation, this method for chemical modification of HA was used in conjunction with new synthetic carbodiimides to prepare HA derivatives bearing lipophilic, aromatic, cross-linked, and tethered functional groups. The degree of conversion to NaHA-acylurea products appears to depend upon both the characteristics of various carbodiimides and the conformational structure of NaHA.

show abstract

“…Figure 5. Synthesis of ethyltridecylcarbodiimide (3) and ethyloctylcarbodiimide (6) and their HA-acylureas 4 and 7. Only N-acylureas were shown, in which R and Ri may be interchanged.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: (C=0)mentioning

confidence: 99%

Section: (C=0)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations