Comparison of the protective efficacy between intratympanic dexamethasone and resveratrol treatments against cisplatin-induced ototoxicity: an experimental study

Şimşek, Gökçe; Taş, Burak Mustafa; Muluk, Nuray Bayar; Azman, Musa; Kılıç, Rahmi

doi:10.1007/s00405-019-05635-x

Cited by 20 publications

(13 citation statements)

References 27 publications

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“…Dexamethasone is anti-inflammatory, anti-apoptotic and anti-oxidant. Several preclinical studies showed positive results indicating significant otoprotection in several models of cisplatin ototoxicity by both systemic as well as local route of administration [111][112][113][114][115][116][117][118][119]. These have been listed in tables 1 and 2.…”

Section: 1mentioning

confidence: 99%

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Strategies to reduce the risk of platinum containing antineoplastic drug-induced ototoxicity

Mukherjea

Dhukhwa²,

Sapra

et al. 2020

Expert Opinion on Drug Metabolism & Toxicology

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Introduction-Cisplatin is a highly effective chemotherapeutic agent against a variety of solid tumors in adults and in children. Unfortunately, a large percentage of patients suffer permanent sensorineural hearing loss. Up to 60% of children and at least 50% of adults suffer this complication that seriously compromises their quality of life. Hearing loss is due to damage to the sensory cells in the inner ear, primarily the outer hair cells and cells of the stria vascularis and spiral ganglion. The mechanisms of cochlear damage are still being investigated. However, it appears that most damage to the inner ear is triggered by reactive oxygen species (ROS) formation and inflammation.Areas covered-In this review we discuss a number of potential therapeutic targets that can be addressed to provide hearing protection. These strategies include enhancing the endogenous antioxidant pathways, heat shock proteins, G protein coupled receptors and counteracting enzymes that produce ROS and reactive nitrogen species, and blocking pathways that produce inflammation, including TRPV1 and STAT1.Expert opinion-A number of potential protective agents show promise in animal models by systemic or local administration by transtympanic or intracochlear injection. However, clinical trials have not shown much efficacy to date with the exception of sodium thiosulfate administration in two studies of pediatric tumors. There is an urgent need to discover safe and effective protective agents that do not interfere with the efficacy of cisplatin against tumors yet preserve hearing.

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Section: 1mentioning

confidence: 99%

“…Drugs in clinical trials are underlined. Chinchilla, Guinea pig Anti-oxidant [190,191] 5 Vitamin E Rat Anti-oxidant [112] 6 Vitamin C Rat Anti-oxidant [192] 7 Dexamethasone Rat Anti-inflammatory [112][113][114] Mouse [115] Aged mouse [116] Guinea pig [117][118]…”

Section: Expert Opinionmentioning

confidence: 99%

Strategies to reduce the risk of platinum containing antineoplastic drug-induced ototoxicity

Mukherjea

Dhukhwa²,

Sapra

et al. 2020

Expert Opinion on Drug Metabolism & Toxicology

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“…ABR thresholds valued after cisplatin administration were found to be less affected in rats that had been treated with dexamethasone and resveratrol (P < 0.001). DPOAE values were maintained in rats treated with dexamethasone and resveratrol (P < 0.001) [33].…”

Section: Inorganic Compoundsmentioning

confidence: 92%

The Effect of Otoprotective Substances Against Cisplatin Exposure: A Literature Review

Gonzalez¹

2020

AJBSR

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“…Group 3 was the experimental group, receiving trans-tympanic administration of 1x 10 5 BM-MSCs in a total volume of 50 µL of PBS. For trans-tympanic administration, a bolus of BM-MSCs or PBS was slowly injected at pars tensa manually under stero-microscope as described in previous studies [31][32][33][34]. After the injection, the animals were kept in the lateral position with the injected ear oriented upward for 15 min before returning them into cages.…”

Section: Experimental Designmentioning

confidence: 99%

Biocompatibility of Bone Marrow-Derived Mesenchymal Stem Cells in the Rat Inner Ear following Trans-Tympanic Administration

Eshraghi

Ocak

Zhu

et al. 2020

JCM

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Recent advancements in stem cell therapy have led to an increased interest within the auditory community in exploring the potential of mesenchymal stem cells (MSCs) in the treatment of inner ear disorders. However, the biocompatibility of MSCs with the inner ear, especially when delivered non-surgically and in the immunocompetent cochlea, is not completely understood. In this study, we determined the effect of intratympanic administration of rodent bone marrow MSCs (BM-MSCs) on the inner ear in an immunocompetent rat model. The administration of MSCs did not lead to the generation of any oxidative stress in the rat inner ear. There was no significant production of proinflammatory cytokines, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and IL-12, due to BM-MSCs administration into the rat cochlea. BM-MSCs do not activate caspase 3 pathway, which plays a central role in sensory cell damage. Additionally, transferase dUTP nick end labeling (TUNEL) staining determined that there was no significant cell death associated with the administration of BM-MSCs. The results of the present study suggest that trans-tympanic administration of BM-MSCs does not result in oxidative stress or inflammatory response in the immunocompetent rat cochlea.

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Comparison of the protective efficacy between intratympanic dexamethasone and resveratrol treatments against cisplatin-induced ototoxicity: an experimental study

Cited by 20 publications

References 27 publications

Strategies to reduce the risk of platinum containing antineoplastic drug-induced ototoxicity

Strategies to reduce the risk of platinum containing antineoplastic drug-induced ototoxicity

The Effect of Otoprotective Substances Against Cisplatin Exposure: A Literature Review

Biocompatibility of Bone Marrow-Derived Mesenchymal Stem Cells in the Rat Inner Ear following Trans-Tympanic Administration

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