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ObjectiveWe aimed to examine the relationship between chronic rhinosinusitis without nasal polyps and microplastics.MethodsA total of 80 patients participated in this prospectively planned study. The patients were divided into two groups. Group 1 had 50 patients with chronic rhinosinusitis without nasal polyps, whereas Group 2 had 30 healthy volunteers. The age and gender of the participants were noted. Nose Obstruction Symptom Evaluation questionnaire was applied to the patients. The patients performed nasal lavage with saline. Microplastics were examined in the collected nasal lavage fluids, and their numbers were noted. The groups were compared on these values.ResultsThe mean age was 38.06 ± 14.15 years in the chronic rhinosinusitis group without nasal polyps and 33.60 ± 11.68 years in the control group. There was no significant difference between the groups in terms of age and gender. There was a significant difference in the number of microplastics between the chronic rhinosinusitis group without nasal polyps and the control group (p < 0.001). Microplastics were detected in all participants.ConclusionsWe found more microplastics in patients with chronic rhinosinusitis without nasal polyps. According to this result, we can say that there may be a relationship between chronic rhinosinusitis and microplastics.Level of Evidence3 Laryngoscope, 2023

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ÖZ ABSTRACTis an antineoplastic agent used in the treatment of many malignant diseases, especially in head and neck tumors, urogenital system, central nervous system, respiratory system and esophagus cancers, in adults and children.Other important dose limiting side effects besides cisplatin nephrotoxicity and irreversible ototoxicity are neurotoxicity, gastrointestinal toxicity, and bone marrow toxicity. Cisplatin shows its autotoxic effect with reactive oxygen products and DNA damage. In cisplatin ototoxicity, bilateral, sensorineural hearing loss is seen clinically at high frequency at the beginning, and at low frequencies including speech voice afterwards. Currently, there is no standard treatment to prevent cisplatindependent ototoxicity.