Comparison of the Sedative and Hemodynamic Effects of Acepromazine and Promethazine in the Standing Horse

Pequito, Manuel; Amory, Hélène; Serteyn, Didier; Busoni, Valéria; Moffarts, Brieuc de; Sandersen, Charlotte

doi:10.1016/j.jevs.2012.03.011

Cited by 7 publications

(5 citation statements)

References 39 publications

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“…The current study is the rst that addressed the effect of xylazine sedation on testicular blood ow, testicular volume and echotexture, and the circulating hormones on goats, despite being a good model of ruminants for studying characterization of the blood ow dynamics in previous literatures (Samir et al 2018b, 2020a, 2020b, 2021; Mandour et al 2020a, 2022).In the current study, no signi cant changes were reported in the Doppler measures and indices of testicular blood ow. Our results agreed that those reported in stallions(Pozor and McDonnell 2004;Pequito et al 2012), and rabbits(Baumgartner et al 2010). An appropriate dose of xylazine was recommended in stallions as it does not induce prominent variations in testicular blood ow(Pozor and McDonnell 2004).…”

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confidence: 93%

Effect of xylazine sedation on testicular blood flow, testicular echotexture, and circulating hormones in Shiba goats

et al. 2022

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Under eld conditions, sedation may be required for a full assessment of the reproductive potential of farm animals. The present study aimed to investigate the effect of xylazine sedation on testicular hemodynamics (TBF), echotexture, testicular volume (TV), and circulating hormones in goats. Sixteen male Shiba goats were sedated using the recommended dose of xylazine (0.05 mg/Kg BW). Testicular hemodynamics were evaluated using color pulsed Doppler ultrasonography before and after sedation. Echotexture of the testicular parenchyma and TV were assessed using computerized image analysis.Concentrations of testosterone, estradiol (E2), inhibin, cortisol, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were measured using radioimmunoassay. There were no effects of xylazine sedation in TBF, TV, testicular parenchyma parameters, testosterone, inhibin, FSH, and LH (P 0.05). However, after sedation, there was signi cantly (P 0.05) lower cortisol and E2 concentration (42.88 ± 6.79 ng/ml and 2.47 ± 0.58 pg/ml, respectively) than before sedation (94.89 ± 13.74 ng/ml and 8.65 ± 1.79 pg/ml, respectively). The required time to perform full scanning of the testis was signi cantly lower (8.50 ± 1.50 min) after xylazine sedation compared to the non-sedated goats (25.75 ± 4.57 min). In conclusion, xylazine sedation may be practically recommended for the evaluation of TBF in goats because it did not signi cantly alter velocities parameters and Doppler indices of blood ow within the testicular arteries. Most plasma hormones did not signi cantly change; however, E2 and cortisol were signi cantly reduced after xylazine administration.

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confidence: 93%

Effect of xylazine sedation on testicular blood flow, testicular echotexture, and circulating hormones in Shiba goats

et al. 2022

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“…Blood pressure was obtained at four different time points: before pharmacological intervention, immediately after phenylephrine infusion, 35 minutes after phenylephrine infusion, and 30 minutes after acepromazine. Time points were chosen based on previously described temporal effects of acepromazine and phenylephrine to detect maximal changes in BP …”

Section: Methodsmentioning

confidence: 99%

“…Time points were chosen based on previously described temporal effects of acepromazine and phenylephrine to detect maximal changes in BP. [14][15][16] Noninvasive blood pressure was obtained and corrected in the AG using the same device and protocol described above. Horses received anesthetic protocols adjusted individually to the needs of the horse and surgical procedure (Supporting Information).…”

Section: Methodsmentioning

confidence: 99%

Accuracy and Precision of Noninvasive Blood Pressure in Normo‐, Hyper‐, and Hypotensive Standing and Anesthetized Adult Horses

Heliczer

Lorello

Casoni

et al. 2016

Veterinary Internal Medicne

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BackgroundBlood pressure is relevant to the diagnosis and management of many medical, cardiovascular and critical diseases. The accuracy of many commonly used noninvasive blood pressure (NIBP) monitors and the accuracy of NIBP measurements in hypo‐ and hypertensive standing horses has not been determined.Hypothesis/ObjectivesThe objective of this study was to investigate the accuracy of an oscillometric BP monitor in standing horses before and during pharmacologically induced hyper‐ and hypotension and to compare results in standing and anesthetized horses.AnimalsEight standing mares from a research herd (SG) and eight anesthetized horses from a hospital population (AG).MethodsProspective experimental and observational studies. Invasive blood pressure (IBP) and NIBP, corrected to heart level, were measured simultaneously. In the SG hyper‐ and hypotension were induced by administration of phenylephrine (3 μg/kg/min IV for 15 minutes) and acepromazine (0.05 mg/kg IV), respectively. In the AG NIBP and IBP were recorded during regular hospital procedures.ResultsThere was a significant correlation between mean NIBP and IBP in standing (R = 0.88, P < .001) and anesthetized horses (R = 0.81, P < .001). The mean bias (lower, upper limit of agreement) was 16.4(−16.1, 48.9) mmHg for mean BP in the SG and 0.5(−22.3, 23.2) mmHg in the AG. The NIBP device was capable of identifying the increase and decrease in BP in all horses, but in the SG significant correlation between NIBP and IBP was only detected for the normotensive phase.Conclusion and Clinical ImportanceWhile the evaluated oscillometric BP device allowed estimation of BP and adequately differentiated marked trends, the accuracy and precision were low in standing horses.

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“…Nuclear scintigraphic examination of the thoracolumbar spine, pelvis and hindlimbs was performed. After 15–20 min of exercise on the track, the mare received 10 mg of acepromazine intravenously (IV) in order to induce vasodilatation (Pequito et al, 2013). Ten minutes later, 4.8 GBq (10 MBq/kg bwt IV) of 99 m technetium‐hydroxymethane diphosphonate (99mTc‐HDP) was injected and furosemide (250 mg, IV) 1.5 h later.…”

Section: Diagnostic Imaging Findingsmentioning

confidence: 99%

“…Nuclear scintigraphic examination of the thoracolumbar spine, pelvis and hindlimbs was performed. After 15-20 min of exercise on the track, the mare received 10 mg of acepromazine intravenously (IV) in order to induce vasodilatation (Pequito et al, 2013) 99 m technetium-hydroxymethane diphosphonate (99mTc-HDP) was injected and furosemide (250 mg, IV) 1.5 h later. Bone phase images were obtained 3 h after injection of 99mTc-HDP according to a standard protocol, the mare being sedated with detomidine (total of 0.2 mg/kg bwt, IV) and morphine (0.1 mg/kg bwt, IV).…”

Section: Diag Nos Tic Imag Ing Finding Smentioning

confidence: 99%

Surgical management of an atypical chronic fracture of the third trochanter of the femur

Tischmacher

Beaumont

Schweitzer³

et al. 2023

Equine Veterinary Education

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Fractures of the third trochanter of the femur are an uncommon cause of hindlimb lameness in the horse. The third trochanter is a salient tuberosity located on the lateral aspect of the femur. It provides insertion for both gluteal and femoral muscles: the gluteus superficialis muscle and caudal part of the tensor fascia latae that insert on its apex and the quadriceps femoris that attaches on its base (Barone, 2000a(Barone, , 2000bBudras et al., 2012). Because of its quite superficial position, the third trochanter is prone to direct traumatic fracture, during a fall on the side. Such fractures can also be caused by an eccentric contraction of the gluteus superficialis muscle during sudden extension and lateral rotation of the hip joint (Bertoni et al., 2013;Denoix, 2014). This can happen either traumatically, typically when a horse stops abruptly (Denoix, unpublished data), if the hind foot slips backward or during a fall (Bertoni et al., 2013) or as a result of repetitive cycles of excessive movement at high speed

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Comparison of the Sedative and Hemodynamic Effects of Acepromazine and Promethazine in the Standing Horse

Cited by 7 publications

References 39 publications

Effect of xylazine sedation on testicular blood flow, testicular echotexture, and circulating hormones in Shiba goats

Effect of xylazine sedation on testicular blood flow, testicular echotexture, and circulating hormones in Shiba goats

Accuracy and Precision of Noninvasive Blood Pressure in Normo‐, Hyper‐, and Hypotensive Standing and Anesthetized Adult Horses

Surgical management of an atypical chronic fracture of the third trochanter of the femur

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