Comparison of the specificity of rheumatoid factor detected by latex fixation with that of regulatory rheumatoid factor

Abstract

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Metabolic syndrome in rheumatoid arthritis patients: Relationship among its clinical components

“…[42][43][44] On the other hand, the association of DAS-28 and VLDL-C levels is not clear yet, but it has been reported that RA patients with high disease activity had alterations of the lipid profile. 38,45 Rheumatoid factor (RF) correlated with age and smoking index, which agrees with other reports [46][47][48] ; likewise, RF correlated with triglycerides, which could be explained by this autoantibody´s positive correlation with a high RA disease activity, 49 a status associated with lipids alteration.…”

Regulatory and other rheumatoid factors in rheumatoid arthritis patients with active disease or in remission

“…Previously we found that in RA patients the RF latex test detects at least two RF populations that differ in their specificity and characteristics. 9 One of them is regRF, which is an immunoregulatory factor in the healthy state. The other population, which is not detected in healthy subjects, is specific to lyophilized IgG.…”

“… 9 Furthermore, the method of agglutination of tanned IgG‐loaded erythrocytes was shown to detect regRF specifically, while the latex test used to detect RF in RA patients detected both regRF and RA‐associated RF, the latter of which is not detected in healthy subjects. 9 …”

“…A comparison of the specificity of regRF with that of the RF associated with human RA indicated that these two RFs are antibodies with different specificities. 9 Both rheumatoid factors are directed at modified human IgG, but to different epitopes thereof. 9 Furthermore, the method of agglutination of tanned IgG‐loaded erythrocytes was shown to detect regRF specifically, while the latex test used to detect RF in RA patients detected both regRF and RA‐associated RF, the latter of which is not detected in healthy subjects.…”

“…9 Both rheumatoid factors are directed at modified human IgG, but to different epitopes thereof. 9 Furthermore, the method of agglutination of tanned IgG-loaded erythrocytes was shown to detect regRF specifically, while the latex test used to detect RF in RA patients detected both regRF and RA-associated RF, the latter of which is not detected in healthy subjects. 9 This new information that there are at least two RF populations that differ in their specificity and function, and that both RF populations are present in the blood of RA patients, makes it necessary to take another look at measurements of RF in RA patients.…”