Comparison of the therapeutic effects of two vanadium complexes administered at low doses on benzo[a]pyrene-induced malignant tumors in rats

Evangelou, Angelos; Karkabounas, Spyridon; Kalpouzos, G.; Malamas, Michael S.; Liasko, Roman; Stefanou, Dimitris; Vlahos, Antonis T.; Kabanos, Themistoklis A.

doi:10.1016/s0304-3835(97)00278-4

Cited by 48 publications

(32 citation statements)

References 8 publications

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“…It has been previously demonstrated that vanadium compounds exert a reduction of tumoral growth both in vivo and in vitro model systems (Molinuevo et al 2004;Kostova 2009;Bishayee et al 1999;Barrio et al 2003;Evangelou et al 1997).…”

Section: Discussionmentioning

confidence: 99%

Cyto- and genotoxicity of a vanadyl(IV) complex with oxodiacetate in human colon adenocarcinoma (Caco-2) cells: potential use in cancer therapy

et al. 2011

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The complex of vanadyl(IV) cation with oxodiacetate, VO(oda) caused an inhibitory effect on the proliferation of the human colon adenocarcinoma cell line Caco-2 in the range of 25-100 μM (P < 0.001). This inhibition was partially reversed by scavengers of free radicals. The difference in cell proliferation in the presence and the absence of scavengers was statistically significant in the range of 50-100 μM (P < 0.05). VO(oda) altered lysosomal and mitochondria metabolisms (neutral red and MTT bioassays) in a dose-response manner from 10 μM (P < 0.001). Morphological studies showed important transformations that correlated with the disassembly of actin filaments and a decrease in the number of cells in a dose response manner. Moreover, VO(oda) caused statistically significant genotoxic effects on Caco-2 cells in the low range of concentration (5-25 μM) (Comet assay). Increment in the oxidative stress and a decrease in the GSH level are the main cytotoxic mechanisms of VO(oda). These effects were partially reversed by scavengers of free radicals in the range of 50-100 μM (P < 0.05). Besides, VO(oda) interacted with plasmidic DNA causing single and double strand cleavage, probably through the action of free radical species. Altogether, these results suggest that VO(oda) is a good candidate to be evaluated for alternative therapeutics in cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Cyto- and genotoxicity of a vanadyl(IV) complex with oxodiacetate in human colon adenocarcinoma (Caco-2) cells: potential use in cancer therapy

et al. 2011

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“…Vanadium is a trace element possessing antitumor effects when administered at proper concentrations in experimentally induced tumors [1][2][3]. It can exert its antitumor effects through modifying various xenobiotic enzymes, thus inhibiting carcinogen-derived active metabolites.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structures and anticancer activities of two decavanadate compounds

Zhu

et al. 2010

Transition Met Chem

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Two ammonium decavanadate(V) compounds, (H 2 tmen) 3 V 10 O 28 Á6H 2 O (1) and (H 2 en) 3 V 10 O 28 Á2H 2 O (2), where H 2 tmen and H 2 en represent the doubly protonated N,N,N 0 ,N 0 -tetramethylethylenediammonium ion and doubly protonated ethylenediammonium ion, respectively, have been synthesized and structurally characterized by elemental analyses, spectroscopic (i.r., e.s.r.) studies, and single-crystal X-ray diffraction. Both crystal structures reveal the presence of the [V 10 O 28 ] 6-cluster anions, doubly protonated diammonium cations, and lattice water molecules. Hydrogen bonds assemble these two compounds to form three-dimensional networks. The in vitro anticancer activity against A549 and P388 tumor cells lines has also been determined by the MTT-based assay, and the results suggest that both compounds can inhibit proliferation of these two kinds of tumor cells.

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“…[2] Nevertheless, vanadium generates significant physiological responses in vivo; [3] for example, vanadate inhibits iontransport ATPases, [4] phosphotyrosine phosphatase, [5] and so forth. Vanadium has also proved effective in treatment of experimentally induced cancers in Wistar rats, [6] but indisputably the most important physiological effect of vanadium is the stimulation of glucose uptake and glucose metabolism, that is, its insulin-like properties. [7] Diabetes is one of many diseases which have been reported to have an oxidative pathology.…”

Section: Introductionmentioning

confidence: 99%

“…On the basis of the additivity relationship, the calculated A z value for the vanadium ± glutathione species with an N 2 O 2 donor atom set is 165. 6 . On the basis of the above discussion the possible structures of V IV O 2 ± glutathione compounds at various pHs are depicted in Figure 4.…”

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confidence: 99%

Synthetic Analogues for Oxovanadium(IV)–Glutathione Interaction: An EPR, Synthetic and Structural Study of Oxovanadium(IV) Compounds with Sulfhydryl‐Containing Pseudopeptides and Dipeptides

Tasiopoulos

Troganis

Evangelou

et al. 1999

Chemistry A European J

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(7) was prepared by the reaction of [VOCl 2 (thf) 2 ] with phen in a methanolic solution. The X-ray structure of 3 shows that the vanadium(iv) atom is ligated to a tridentate mpg 3À ligand at the S thiolato , N peptide and O carboxylato atoms. The X-ray structure of 7 is also reported. The optical, infrared, magnetic, electron paramagnetic resonance, and electrochemical properties of compounds 1 ± 5Ć H 3 OH and 7 were studied. Combination of the correlation plots of the EPR parameters g z versus A z , or the groundstate orbital population (b*) 2 versus A z , together with the additivity relationship, A z,calcd Sn i A zi /4, were shown to provide a powerful tool for probing the equatorial donor atoms in an oxovanadium(iv) compound and consequently in biomolecules. Thus, these methods provide valuable evidence for the assignment of the equatorial donor atoms for the V IV O 2 center of the V IV O 2 ± glutathione system at various pH values. Model NMR studies (interaction of vanadium(v) with H 3 mpg) showed that there is a possibility of vanadium(v) ligation to glutathione. The contribution of a deprotonated peptide(amide) nitrogen to A z is not a fixed quantity (it varies from 29 to 43 Â 10 À4 cm À1), but is influenced by the presence of the three other donor atoms in the equatorial plane and, in particular, their charge.

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Comparison of the therapeutic effects of two vanadium complexes administered at low doses on benzo[a]pyrene-induced malignant tumors in rats

Cited by 48 publications

References 8 publications

Cyto- and genotoxicity of a vanadyl(IV) complex with oxodiacetate in human colon adenocarcinoma (Caco-2) cells: potential use in cancer therapy

Cyto- and genotoxicity of a vanadyl(IV) complex with oxodiacetate in human colon adenocarcinoma (Caco-2) cells: potential use in cancer therapy

Synthesis, crystal structures and anticancer activities of two decavanadate compounds

Synthetic Analogues for Oxovanadium(IV)–Glutathione Interaction: An EPR, Synthetic and Structural Study of Oxovanadium(IV) Compounds with Sulfhydryl‐Containing Pseudopeptides and Dipeptides

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