Comparison of the transcriptional profiles of head and body lice

Olds, Brett P.; Coates, Brad S.; Steele, Laura D.; Sun, Weilin; Agunbiade, Tolulope A.; Yoon, Kyong Sup; Strycharz, Joseph P.; Lee, S. H.; Paige, Ken N.; Clark, J. Marshall; Pittendrigh, Barry R.

doi:10.1111/j.1365-2583.2012.01132.x

Cited by 48 publications

(52 citation statements)

References 43 publications

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“…The second study was based on the PM2 spacer [23] and could not show head and body louse divergence within each of the two clusters. Head and body lice were also shown to be genetically indistinguishable in a worldwide study based on four intergenic spacers [24] and in a very recent study based on the louse transcriptome [25]. Finally, based on a Bayesian coalescent model, ancestral migration events between head and body lice were shown to happen in both directions [26].…”

Section: Introductionmentioning

confidence: 81%

Evidence That Head and Body Lice on Homeless Persons Have the Same Genotype

et al. 2012

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Human head lice and body lice are morphologically and biologically similar but have distinct ecologies. They were shown to have almost the same basic genetic content (one gene is absent in head lice), but differentially express certain genes, presumably responsible for the vector competence. They are now believed to be ecotypes of the same species (Pediculus humanus) and based on mitochondrial studies, body lice have been included with head lice in one of three clades of human head lice (Clade A). Here, we tested whether head and body lice collected from the same host belong to the same population by examining highly polymorphic intergenic spacers. This study was performed on lice collected from five homeless persons living in the same shelter in which Clade A lice are prevalent. Lice were individually genotyped at four spacer loci. The genetic identity and diversity of lice from head and body populations were compared for each homeless person. Population genetic structure was tested between lice from the two body regions and between the lice from different host individuals.We found two pairs of head and body lice on the same homeless person with identical multi locus genotypes. No difference in genetic diversity was found between head and body louse populations and no evidence of significant structure between the louse populations was found, even after controlling for a possible effect of the host individual. More surprisingly, no structure was obvious between lice of different homeless persons.We believe that the head and body lice collected from our five subjects belong to the same population and are shared between people living in the same shelter. These findings confirm that head and body lice are two ecotypes of the same species and show the importance of implementing measures to prevent lice transmission between homeless people in shelters.

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Section: Introductionmentioning

confidence: 81%

Evidence That Head and Body Lice on Homeless Persons Have the Same Genotype

et al. 2012

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“…A recent review includes the information on the specific sequences found in parasites and their homologies with miRNA sequences of other organisms [2]. After this review, the number of identified miRNA sequences in parasites in which miRNAs were already known has increased due to large scale sequencing experiments, and new miRNA sequences have been also described in parasites in which miRNAs had not been evidenced before (see http://www.mirbase.org/search.shtml; [12][13][14][15]; Fig. 1).…”

Section: Micrornas In Parasites: a Growing Collection Of Sequence Infmentioning

confidence: 99%

MicroRNAs in parasitic diseases: Potential for diagnosis and targeting

Manzano-Román

Siles-Lucas

2012

Molecular and Biochemical Parasitology

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“…Similarly, human body lice are thought to have emerged as an alternative morph of human head lice since the use of clothing became widespread. While there were no significant differences detected in which genes were expressed between the two morphs [34], morph-specific alternative splicing events were detected for over a thousand genes [35]. In particular, body lice-specific alternative splicing events were enriched in genes associated with developmental gene ontology terms [35].…”

Section: Introductionmentioning

confidence: 96%

Alternative splicing and the evolution of phenotypic novelty

Bush

Chen

Tovar-Corona

et al. 2017

Phil. Trans. R. Soc. B

168

122

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One contribution of 17 to a theme issue 'Evo-devo in the genomics era, and the origins of morphological diversity'. Alternative splicing, a mechanism of post-transcriptional RNA processing whereby a single gene can encode multiple distinct transcripts, has been proposed to underlie morphological innovations in multicellular organisms. Genes with developmental functions are enriched for alternative splicing events, suggestive of a contribution of alternative splicing to developmental programmes. The role of alternative splicing as a source of transcript diversification has previously been compared to that of gene duplication, with the relationship between the two extensively explored. Alternative splicing is reduced following gene duplication with the retention of duplicate copies higher for genes which were alternatively spliced prior to duplication. Furthermore, and unlike the case for overall gene number, the proportion of alternatively spliced genes has also increased in line with the evolutionary diversification of cell types, suggesting alternative splicing may contribute to the complexity of developmental programmes. Together these observations suggest a prominent role for alternative splicing as a source of functional innovation. However, it is unknown whether the proliferation of alternative splicing events indeed reflects a functional expansion of the transcriptome or instead results from weaker selection acting on larger species, which tend to have a higher number of cell types and lower population sizes.This article is part of the themed issue 'Evo-devo in the genomics era, and the origins of morphological diversity'.

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Comparison of the transcriptional profiles of head and body lice

Cited by 48 publications

References 43 publications

Evidence That Head and Body Lice on Homeless Persons Have the Same Genotype

Evidence That Head and Body Lice on Homeless Persons Have the Same Genotype

MicroRNAs in parasitic diseases: Potential for diagnosis and targeting

Alternative splicing and the evolution of phenotypic novelty

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