2009
DOI: 10.1016/j.vaccine.2009.03.088
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Comparison of the trivalent live attenuated vs. inactivated influenza vaccines among U.S. military service members

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Cited by 43 publications
(45 citation statements)
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“…It is possible that variations in study endpoint and population, and season‐to‐season variability may contribute to the conflicting results regarding the relative efficacy of LAIV and TIV in adults 14 , 19 , 28 . In the more robust pediatric data, there is evidence to suggest that LAIV efficacy does not decline with increasing age.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…It is possible that variations in study endpoint and population, and season‐to‐season variability may contribute to the conflicting results regarding the relative efficacy of LAIV and TIV in adults 14 , 19 , 28 . In the more robust pediatric data, there is evidence to suggest that LAIV efficacy does not decline with increasing age.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, comparative studies in adults ≥18 years of age have demonstrated variable results; studies have demonstrated comparable protection of the two vaccines, 12 , 13 , 14 , 15 , 16 greater protection with TIV, 17 , 18 , 19 and, in some cases, greater protection with LAIV 19 . For studies that have demonstrated greater protection with TIV in adults, authors have speculated that LAIV may be less effective in older individuals because of prior infections with similar wild‐type influenza strains 15 , 17 , 18 , 19 …”
Section: Introductionmentioning
confidence: 99%
“…However, in a retrospective cohort study comparing LAIV3 and IIV3 among 701,753 nonrecruit military personnel and 70,325 new recruits, among new recruits, incidence of ILI was lower among those who received LAIV3 than IIV3. The previous vaccination status of the recruits was not stated; it is possible that this population was relatively naïve to vaccination compared with previous service members who were more likely to have been vaccinated routinely each year (261).…”
Section: Comparisons Of Laiv3/4 and Iiv Efficacy Or Effectivenessmentioning
confidence: 99%
“…Three randomized, controlled efficacy trials in children of Ͼ6 months and Յ18 years of age consistently demonstrated that LAIV was significantly more protective than IIV (4)(5)(6)(7). Similarly, for adults older than 16 years, some comparative trials showed that LAIV was at least as effective as IIV (8)(9)(10). However, 2 adult trials showed that IIV was more protective than LAIV (11)(12)(13), and thus there is some controversy over whether LAIV can be as effective as a well-matched IIV seasonal vaccine for adults with previously extensive influenza virus exposure (2,14).…”
mentioning
confidence: 97%