Comparison of the Use of Domperidone, Droperidol and Metoclopramide in the Prevention of Nausea and Vomiting Following Gynaecological Surgery in Day Cases

Madej, T.H.; Simpson, K.H.

doi:10.1093/bja/58.8.879

Cited by 104 publications

(38 citation statements)

References 15 publications

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“…[13,17]. Previous studies have provided conflicting results regarding metoclopramide; Madej and Simpson [18] found metoclopramide effective in preventing PONV, while Fujii [19] found it ineffective in a similar work. Ferrari et al [12] found metoclopramide effective in preventing PONV after tonsillectomy in children, as did Lin et al [20] after strabismus surgery.…”

Section: Discussionmentioning

confidence: 99%

A Randomized Comparison of Droperidol, Metoclopramide, Tropisetron, and Ondansetron for the Prevention of Postoperative Nausea and Vomiting

Ekinci

Malat

Işıtmangil

et al. 2010

Gynecol Obstet Invest

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Background: Nausea and vomiting are the most common causes of postoperative complications, and they are seen most often after operations performed using general anesthesia and sedation. We designed this study to compare the effects of droperidol, metoclopramide, tropisetron, and ondansetron for the prevention of postoperative nausea and vomiting in patients undergoing gynecologic operations. Methods: One hundred patients were randomly assigned to 1 of 5 groups: group D was given 2.5 mg droperidol; group M, 10 mg metoclopramide; group T, 2.5 mg tropisetron; group O, 4 mg ondansetron 5 min after induction, and group C was the control group and received no prophylactic antiemetic treatment. All patients were observed for sedation and postoperative nausea and vomiting for 48 h. Results: Within 24 h after the operation, severe postoperative nausea and vomiting were seen in 4 patients (20%) in group D, 8 (40%) in group M, 5 (25%) in group T, 3 (15%) in group O, and 12 patients (60%) in the control group. Patients receiving droperidol, tropisetron, and ondansetron had significantly less serious emesis than the control group (p < 0.05). Sedation was seen in 5 patients receiving droperidol (4 patients score 2; and 1 patient score 3) and tropisetron (2 patients score 2; and 3 patients score 3) 15 min after surgery; this was significantly higher than in the control group (p < 0.05). Conclusion: We conclude that metoclopramide is not effective in preventing postoperative nausea and vomiting after gynecologic operations. Droperidol, tropisetron, and ondansetron are effective; however, the sedating effects of droperidol and tropisetron should be considered.

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Section: Discussionmentioning

confidence: 99%

A Randomized Comparison of Droperidol, Metoclopramide, Tropisetron, and Ondansetron for the Prevention of Postoperative Nausea and Vomiting

Ekinci

Malat

Işıtmangil

et al. 2010

Gynecol Obstet Invest

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“…Several studies have recommended doses of 2.5 mg droperidol to prevent PONV [8,9]. So we chose a dose of 2.5 mg droperidol, although recent data have suggested that a dose of 20 µg·kg −1 [10] or lower [7] might also be effective.…”

Section: Discussionmentioning

confidence: 99%

The use of droperidol decreases postoperative nausea and vomiting after gynecological laparoscopy

2007

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We evaluated whether or not routine prophylaxis with 2.5 mg of droperidol would efficiently prevent postoperative nausea and vomiting (PONV). Fifty-two patients scheduled for elective gynecological laparoscopic surgery were eligible for this study. Anesthesia was induced using propofol, fentanyl, and vecuronium, and maintained with sevoflurane in nitrous oxide, fentanyl, and vecuronium. Patients were randomized to one of two groups: group 1 patients (n = 23) received 2.5 mg droperidol intravenously when the surgery was started, while group 2 patients (n = 29) did not receive any droperidol. At the conclusion of the surgery, the patient was extubated on satisfactory emergence from general anesthesia. Any episodes of nausea and vomiting, rescue medications, and adverse effects were recorded until the next morning after the surgery. There were no differences in the duration of anesthesia on surgery between the groups, but the total fentanyl dose in group 1 was higher than that in group 2. Episodes of nausea and vomiting and the need for metoclopramide in group 1 were lower than in group 2, though the total fentanyl dose in group 1 was higher than in group 2. There were no differences in the need for analgesics between the groups. The use of 2.5 mg droperidol safely decreased PONV after gynecological laparoscopy.

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“…Several agents have been used for prevention of PONV after LC. Dexamethasone and metoclopramide have been shown to be effective but their use is limited by the possible side effects [5,10,16]. Ondansetron, a highly selective 5-HT3 receptor antagonist, is effective in the prevention of chemotherapy-induced emesis [6].…”

Section: Discussionmentioning

confidence: 99%

Ondansetron in the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy

Cheong

Sng

et al. 2001

Surg Endosc

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Comparison of the Use of Domperidone, Droperidol and Metoclopramide in the Prevention of Nausea and Vomiting Following Gynaecological Surgery in Day Cases

Cited by 104 publications

References 15 publications

A Randomized Comparison of Droperidol, Metoclopramide, Tropisetron, and Ondansetron for the Prevention of Postoperative Nausea and Vomiting

A Randomized Comparison of Droperidol, Metoclopramide, Tropisetron, and Ondansetron for the Prevention of Postoperative Nausea and Vomiting

The use of droperidol decreases postoperative nausea and vomiting after gynecological laparoscopy

Ondansetron in the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy

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