Ondansetron in the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy

So, Jimmy Bok Yan; Cheong, Keng Fatt; Sng, Chelvin C. A.; Cheah, Wei-Keat; Goh, P. M. Y.

doi:10.1007/s00464-001-9036-3

Cited by 21 publications

(10 citation statements)

References 12 publications

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“…Many authors have reported an increased incidence of PONV in patients after laparoscopic cholecystectomy. On the basis of these cases, the effectiveness of various pharmacologic products was compared [3,10,11,14,19].…”

Section: Discussionmentioning

confidence: 99%

Ondansetron, metoclopramid, dexamethason, and their combinations compared for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a prospective randomized study

2006

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Section: Discussionmentioning

confidence: 99%

Ondansetron, metoclopramid, dexamethason, and their combinations compared for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a prospective randomized study

2006

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“…is effective for the prevention of PONV after laparoscopic cholecystectomy [24][25][26]. However, Koivuranta et al and So et al found no difference in antiemetic efficacy between patients who had received ondansetron 4 mg and those who had received placebo [27,28]. Several investigations compared the prophylactic antiemetic efficacy of ondansetron with other commonly used and well-established antiemetics (e.g., droperidol and metoclopramide) in patients scheduled for laparoscopic cholecystectomy, and showed that preoperative prophylactic i.v.…”

Section: Serotonin Receptor Antagonists (Table 3)mentioning

confidence: 98%

“…Headache is the most commonly reported adverse event in clinical trials of serotonin receptor antagonists for PONV after laparoscopic cholecystectomy. Other known side effects include abdonimal pain, constipation, and elevated liver enzyme [7,17,[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40]. Extrapyramidal reactions have been reported in patients receiving ondansetron performed under general anesthesia [77,78].…”

Section: Serotonin Receptor Antagonists (Table 3)mentioning

confidence: 99%

“…Serotonin receptor antagonists (ondansetron, granisetron, tropisetron, dolasetron, and ramosetron) are highly efficacious for PONV following laparoscopic cholecystectomy [7,17,[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39]. Their actions involve both central and peripheral mechanisms in the control of nausea and vomiting.…”

Section: Serotonin Receptor Antagonists (Table 3)mentioning

confidence: 99%

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The Utility of Antiemetics in the Prevention and Treatment of Postoperative Nausea and Vomiting in Patients Scheduled for Laparoscopic Cholecystectomy

Fujii

2005

CPD

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Postoperative nausea and vomiting (PONV) are distressing and frequent adverse events of anesthesia and surgery, with a relatively high incidence after laparoscopic cholecystectomy. Numerous antiemetics have been studied for the prevention and treatment of PONV in patients scheduled for laparoscopic cholecystectomy. Traditional antiemetics, including anticholinergics (e.g., scopolamine), antihistamines (e.g., dimenhydrinate), phenothiazines (e.g., promethazine), butyrophenones (e.g., droperidol), and benzamide (e.g., metoclopramide), are used for the control of PONV. The available nontraditional antiemetics for the prophylaxis against PONV are dexamethasone and propofol. Serotonin receptor antagonists (ondansetron, granisetron, tropisetron, dolasetron, and ramosetron), compared with traditional antiemetics, are highly efficacious for PONV. The prophylactic ondansetron, granisetron, tropisetron, and dolasetron in antiemetic efficacy are comparable. Ramosetron is effective for the long-term prevention of PONV. None of the available antiemetics is entirely effective, perhaps because most of them act through the blockade on one type of receptor. There is a possibility that combined antiemetics with different sites of activity would be more effective than one drug alone for the prophylaxis against PONV. Combination antiemetic therapy is often effective for the prevention of PONV following laparoscopic cholecystectomy. The efficacy of a combination of serotonin receptor antagonists (ondansetron and granisetron) and droperidol is superior to monotherapy with a serotonin receptor antagonist or droperidol. Similarly, adding dexamethasone to ondansetron or granisetron improves antiemetic efficacy in PONV. Knowledge regarding antiemetics is necessary to completely prevent and treatment of PONV in patients scheduled for laparoscopic cholecystectomy.

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“…Postoperative nausea and vomiting are relatively common after laparoscopic cholecystectomy under general anesthesia [17]. One of the patients developed postoperative nausea and vomiting, while three patients in the general anesthesia group developed this complication.…”

Section: Tab 3 Postoperative Side-effects and Duration Of Blockadementioning

confidence: 99%

RETRACTED ARTICLE: Different anesthesia methods for laparoscopic cholecystectomy

et al. 2011

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Ondansetron in the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy

Abstract: Routine use of ondansetron does not reduce the incidence of postoperative nausea and vomiting after laparoscopic cholecystectomy.

Cited by 21 publications

References 12 publications

Ondansetron, metoclopramid, dexamethason, and their combinations compared for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a prospective randomized study

Ondansetron, metoclopramid, dexamethason, and their combinations compared for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a prospective randomized study

The Utility of Antiemetics in the Prevention and Treatment of Postoperative Nausea and Vomiting in Patients Scheduled for Laparoscopic Cholecystectomy

RETRACTED ARTICLE: Different anesthesia methods for laparoscopic cholecystectomy

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