Comparison of Three Anxiety Management Protocols for Extraction of Third Molars With the Use of Midazolam, Diazepam, and Nitrous Oxide: A Randomized Clinical Trial

Moares, Michelle Bianchi de; Barbier, Winnie Souza; Raldi, Fernando Vagner; Nascimento, Rodrigo Dias; Santos, Lúcio Murilo dos; Sato, Fábio Ricardo Loureiro

doi:10.1016/j.joms.2019.06.001

Cited by 18 publications

(15 citation statements)

References 17 publications

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“…Face a isto, ao se optar pela técnica de sedação consciente, é importante ter a ciência de qual droga pode promover uma melhor estabilidade hemodinâmica, esta que também reflete o nível de ansiedade. Neste sentido, torna-se válida a investigação de tais efeitos entre o diazepam e o midazolam por via oral, sendo estes os medicamentos mais empregados por esta via (Wannmacher & Ferreira, 1999;Moraes et al, 2015;Khader et al, 2015;De Moares et al, 2019;Frazão & Filippe, 2020). Pois, embora o diazepam e o midazolam pertençam a mesma classe de medicamentos, há diferenças farmacocinéticas e farmacodinâmicas.…”

Section: Resultsunclassified

Comparação das alterações hemodinâmicas entre dois benzodiazepínicos frente à sedação consciente em exodontias de terceiros molares: um protocolo de revisão sistemática

Silva

Junior

Andrade

et al. 2021

RSD

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Objetivos: O presente trabalho pretende apresentar um protocolo de uma revisão sistemática que busca comparar as alterações hemodinâmicas ocorridas em pacientes que foram submetidos à técnica de sedação consciente por via oral com o diazepam versus o midazolam, durante a exodontia de terceiros molares inferiores. Métodos: Protocolo para uma revisão sistemática de ensaios clínicos randomizados, sendo utilizado as bases de dados Embase, PubMed/MEDLINE, Cochrane Library, Portal Regional da BVS, literatura cinzenta e buscas de forma manual nos principais periódicos da área de cirurgia bucomaxilofacial. O referido protocolo foi registrado no International Prospective Register of Systematic Reviews (PROSPERO), ressaltando-se que esta revisão será conduzida de acordo com as diretrizes do Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Considerações finais: A necessidade de se manter a maior estabilidade hemodinâmica durante a exodontia de terceiros molares inferiores, frente a sedação consciente por via oral, torna relevante que esta revisão sistemática seja realizada.

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Section: Resultsunclassified

Comparação das alterações hemodinâmicas entre dois benzodiazepínicos frente à sedação consciente em exodontias de terceiros molares: um protocolo de revisão sistemática

Silva

Junior

Andrade

et al. 2021

RSD

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“…After removing the granulation tissue via curettage, sufficient normal saline irrigation of the extraction socket was performed. The flap was repositioned, and sutures were placed with a non-absorbable suture (4-0 dafilon; B. Braun Korea, Seoul, Korea) after confirming that no residual tooth or root fragments were present 8 .…”

Section: Methodsmentioning

confidence: 99%

Comparison of vital sign stability and cost effectiveness between midazolam and dexmedetomidine during third molar extraction under intravenous sedation

Kim

Park

Han

et al. 2022

JKAOMS

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Objectives: To compare the vital sign stability and cost of two commonly used sedatives, midazolam (MDZ) and dexmedetomidine (DEX). Patients and Methods: This retrospective study targeted patients who underwent mandibular third molar extractions under intravenous sedation using MDZ or DEX. The predictor variable was the type of sedative used. The primary outcome variables were vital signs (heart rate and blood pressure), vital sign outliers, and cost of the sedatives. A vital sign outlier was defined as a 30% or more change in vital signs during sedation; the fewer changes, the higher the vital sign stability. The secondary outcome variables included the observer's assessment of alertness/sedation scale, level of amnesia, patient satisfaction, and bispectral index score. Covariates were sex, age, body mass index, sleeping time, dental anxiety score, and Pederson scale. Descriptive statistics were computed including propensity score matching (PSM). The P-value was set at 0.05. Results: The study enrolled 185 patients, 103 in the MDZ group and 82 in the DEX group. Based on the data after PSM, the two samples had similar baseline covariates. The sedative effect of both agents was satisfactory. Heart rate outliers were more common with MDZ than with DEX (49.3% vs 22.7%, P=0.001). Heart rate was higher with MDZ (P=0.000). The cost was higher for DEX than for MDZ (29.27±0.00 USD vs 0.37±0.04 USD, P=0.000). Conclusion: DEX showed more vital sign stability, while MDZ was more economical. These results could be used as a reference to guide clinicians during sedative selection.

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“…Oral midazolam has been found to be an effective anxiolytic in pediatric and adult patients undergoing dermatologic procedures 32 . Similarly, oral diazepam has been shown to provide anxiolysis during outpatient surgical procedures 33 . However, while generally safe in healthy patients, the perioperative administration of benzodiazepines may necessitate more monitoring and postoperative planning, such as arranging for transportation.…”

Section: Intraoperative Pain Managementmentioning

confidence: 99%

Managing pain associated with dermatologic procedures

et al. 2021

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Dermatologists are faced with an aging population, accompanied by an increase in the incidence of skin cancer, especially nonmelanoma skin cancer. With this increase in cutaneous malignancy comes an increase in the number of dermatologic procedures being performed. A common concern of dermatologists and dermatology patients is the attenuation and management of pain associated with dermatologic procedures. Fortunately, there are several techniques that may be used in the preoperative, intraoperative, and postoperative periods to manage patient anxiety, minimize injection pain, and safely and effectively treat postoperative pain.

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Comparison of Three Anxiety Management Protocols for Extraction of Third Molars With the Use of Midazolam, Diazepam, and Nitrous Oxide: A Randomized Clinical Trial

Cited by 18 publications

References 17 publications

Comparação das alterações hemodinâmicas entre dois benzodiazepínicos frente à sedação consciente em exodontias de terceiros molares: um protocolo de revisão sistemática

Comparação das alterações hemodinâmicas entre dois benzodiazepínicos frente à sedação consciente em exodontias de terceiros molares: um protocolo de revisão sistemática

Comparison of vital sign stability and cost effectiveness between midazolam and dexmedetomidine during third molar extraction under intravenous sedation

Managing pain associated with dermatologic procedures

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