Comparison of thyroglobulin and thyroid peroxidase antibodies measured by five different kits in autoimmune thyroid diseases

Nishihara, Eijun; Amino, Nobuyuki; Kudo, Takumi; M, Ito; Fukata, Shuji; Nishikawa, Mitsushige; Nakamura, Hirotoshi; Miyauchi, Akira

doi:10.1507/endocrj.ej17-0164

Cited by 19 publications

(13 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is also important to recall that the diagnostic accuracy of thyroid autoantibodies is more dependent on the type of assay used than is usually acknowledged. In a survey using 5 different assay kits, there was the discordance between positive and negative results for thyroglobulin and TPO antibodies, and correlation between kits ranged widely [38]. For 4 of the assays, thyroglobulin antibodies were more frequent (99%) that TPO antibodies (81%) in HT, making the former the test of choice in this Japanese cohort.…”

Section: Thyroid Autoantibodiesmentioning

confidence: 86%

An update on the pathogenesis of Hashimoto’s thyroiditis

Weetman

2020

J Endocrinol Invest

136

View full text Add to dashboard Cite

It is 70 years since Noel Rose embarked on his pioneering studies that lead to the discovery of autoimmune thyroiditis and the elucidation of Hashimoto’s thyroiditis. This short review to honour his passing focuses on the developments in our understanding of the causes and pathogenesis of HT over the last five years. Recent genetic studies have reported heritability estimates for HT and associated diseases for the first time, and emphasised the complexity of the genetic factors involved, including monogenic forms of HT. Environmental factors continue to be elucidated, especially as a side effect of drugs which modulate the immune system therapeutically. Regarding pathogenetic mechanisms, multiple cytokine networks have been identified which involve the thyroid cells in a circuit of escalating proinflammatory effects, such as the expression of inflammasome components, and an array of different defects in T regulatory cells may underlie the loss of self-tolerance to thyroid autoantigens. Finally, a number of studies have revealed fresh insights into disease associations with HT which may have both pathological and clinical significance, the most intriguing of which is a possible direct role of the autoimmune process itself in causing some of the persistent symptoms reported by a minority of patients with levothyroxine-treated HT.

show abstract

Section: Thyroid Autoantibodiesmentioning

confidence: 86%

An update on the pathogenesis of Hashimoto’s thyroiditis

Weetman

2020

J Endocrinol Invest

136

View full text Add to dashboard Cite

show abstract

“…In present case, however, both anti-TG and anti-TPO antibodies were negative. Anti-thyroglobulin and anti-TPO antibodies prevalence in painless thyroiditis have been reported to be 70 and 30%, respectively [19]. The patient had an history of acute pancreatitis.…”

Section: Discussionmentioning

confidence: 86%

A case of thyrotoxicosis-induced anemia in a patient with painless thyroiditis

Komiya¹,

Tomoyose

Yagi³

et al. 2021

Thyroid Res

View full text Add to dashboard Cite

Background There have been several reports of secondary anemia associated with Graves’ disease. There are no reports of secondary anemia resulting from thyrotoxicosis due to painless thyroiditis (silent thyroiditis). We report the case of a patient with pancreatic diabetes who developed anemia caused by thyrotoxicosis due to painless thyroiditis. Case presentation The patient was a 37-year-old man who visited the hospital complaining of fatigue, palpitations, and dyspnea. His hemoglobin was 110 g/l (reference range, 135–176), and mean corpuscular volume was 81.5 fl (81.7–101.6). His free thyroxine (FT4) was high, at 100.4 pmol/l (11.6–21.9); the free triiodothyronine (FT3) was high, at 27.49 pmol/l (3.53–6.14); TSH was low, at < 0.01 mIU/l (0.50–5.00); and TSH receptor antibody was negative. Soluble IL-2 receptor (sIL-2R) was high, at 1340 U/ml (122–496); C-reactive protein (CRP) was high, at 6900 μg/l (< 3000); and reticulocytes was high, at 108 109 /l (30–100). Serum iron (Fe) was 9.5 (9.1–35.5), ferritin was 389 μg/l (13–401), haptoglobin was 0.66 g/l (0.19–1.70. Propranolol was prescribed and followed up. Anemia completely disappeared by 12 weeks after disease onset. Thyroid hormones and sIL-2R had normalized by 16 weeks after onset. He developed mild hypothyroidism and was treated with L-thyroxine at 24 weeks. Conclusions This is the first case report of transient secondary anemia associated with thyrotoxicosis due to painless thyroiditis. The change in sIL-2R was also observed during the clinical course of thyrotoxicosis and anemia, suggesting the immune processes in thyroid gland and bone marrow.

show abstract

“…Our patient was diagnosed with the APS type 3A, 3B, and 3D variants together with euthyroid Hashimoto’s thyroiditis. Moreover, comparison of the prevalence rates between TPOAb and TgAb in healthy controls showed values of about 1.2%–27.8% and 1.2%–30%, respectively, in various places in different countries ( 9 ). Since her TPOAb and TgAb were of very high titers, she was diagnosed with euthyroid Hashimoto’s thyroiditis, even though she suffered from potential Hashimoto’s thyroiditis.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Onset of Type 1 Diabetes Mellitus in a Patient With Ulcerative Colitis and Sjogren’s Syndrome Under Euthyroid Hashimoto’s Thyroiditis

et al. 2022

View full text Add to dashboard Cite

Type 1 diabetes mellitus (T1DM) is often complicated with some other autoimmune disorders. The complication of various autoimmune disorders is known as autoimmune polyglandular syndrome (APS). Once autoimmune thyroid disease develops, various autoimmune diseases can also occur. Such phenomena are classified as APS types 3A to 3D. In this report, we show the onset of T1DM in a patient with ulcerative colitis (UC) and Sjogren’s syndrome. The most important and interesting point in this case is that, if we did not check her thyroid-associated antibodies, we could not have diagnosed her as APS. From the data of this case, we assumed that the patient suffered from APS type 3A, 3B, and 3D variants. This case pointed out very clearly the importance of testing for thyroid-associated antibodies under various autoimmune disease conditions even if the thyroid hormone levels are euthyroid. Moreover, based on the strong linkage between inflammatory bowel disease and T1DM and the compatibility with both T1DM and APS type 3, we think it is possible that Hashimoto’s disease is present under complicated conditions together with UC and T1DM. It would be important to repeatedly check for thyroid-associated antibodies even in euthyroid patients, especially under various autoimmune disease conditions.

show abstract

Comparison of thyroglobulin and thyroid peroxidase antibodies measured by five different kits in autoimmune thyroid diseases

Cited by 19 publications

References 34 publications

An update on the pathogenesis of Hashimoto’s thyroiditis

An update on the pathogenesis of Hashimoto’s thyroiditis

A case of thyrotoxicosis-induced anemia in a patient with painless thyroiditis

Case Report: Onset of Type 1 Diabetes Mellitus in a Patient With Ulcerative Colitis and Sjogren’s Syndrome Under Euthyroid Hashimoto’s Thyroiditis

Contact Info

Product

Resources

About