Comparison of thyroid function in pregnant and non-pregnant Asian and western Caucasian women

Price, A.; Obel, Owen; Cresswell, Janet; Catch, Ian; Rutter, S.; Barik, Sukumar; Heller, Simon; Weetman, Anthony P.

doi:10.1016/s0009-8981(01)00470-3

Cited by 63 publications

(49 citation statements)

References 24 publications

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“…In our longitudinal study, TSH values in ThAb negative Japanese are generally comparable to the reference range for serum TSH during pregnancy defined in populations with optimal iodine intake recently reported by the ATA [22]. Although slight but significant ethnic differences in serum TSH concentration have been reported [54], our median TSH values are not lower than in Caucasian women. Free T 4 reference intervals in pregnancy varied widely between methods and were also influenced by the iodine status of the population.…”

Section: Disclosuresupporting

confidence: 86%

Gestational changes of thyroid function and urinary iodine in thyroid antibody-negative Japanese women

2013

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Section: Disclosuresupporting

confidence: 86%

Gestational changes of thyroid function and urinary iodine in thyroid antibody-negative Japanese women

2013

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“…The latter possibility would indicate real differences in the setpoint of the HPT axis between our subjects. Indeed ethnic differences in ambient TSH values but not in FT 4 values suggest an effect of race (17,18), and slightly lower TSH values have been observed in carriers of the Asp727Glu polymorphism in the TSH receptor gene occurring in about 20% of a Caucasian population (19). The low prevalence of this TSH receptor polymorphism does not favour possibility iii) in our (mostly Caucasian) subjects.…”

Section: Discussionmentioning

confidence: 56%

Pilot study on the assessment of the setpoint of the hypothalamus–pituitary–thyroid axis in healthy volunteers

Benhadi

Fliers

Visser

et al. 2010

European Journal of Endocrinology

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Objective: To determine the log-linear relationship between TSH and free thyroxine in healthy subjects, and the variation in baseline TSH/free thyroxine (FT 4 ) combination in each individual. Subjects and methods: Twenty-one healthy volunteers (nine males and 12 females; mean age 60 years, range 51-74) were randomized to receive at 2300 h with 2-week intervals a single dose of placebo, 125 mg T 4 and 250 mg T 4 (arm 1, nZ10), or placebo, 25 mg triiodothyronine (T 3 ) and 50 mg T 3 (arm 2, nZ11). Blood samples were taken in the morning (0800-1100 h) before and following the administration of the drug for the assessment of TSH, FT 4 and T 3 . Results: Intra-and inter-individual variation and the individuality index of the four baseline serum samples were respectively 21.6%, 41.9% and 0.52 for TSH; 9.9%, 16.5% and 0.60 for FT 4 ; and 9.3%, 16.0% and 0.58 for T 3 . Substantial differences existed in the location of individual working points within the reference range. T 4 administration increased FT 4 (but not T 3 ) and decreased TSH, resulting in a log-linear relationship (log TSHZ1.50-0.059!FT 4 , P!0.05) for the whole group. T 3 administration increased T 3 and decreased TSH (but not FT 4 ), resulting in a log-linear relationship (log TSHZ0.790-0.245!T 3 , P!0.001) for the whole group. Log-linear relationships were not always significant when assessed for each subject separately. Conclusion: Individuality indices of TSH, FT 4 and T 3 are all %0.6, thereby limiting the usefulness of the population-based reference values. Accurate assessment of individual setpoints of the HPT axis was not possible with the applied single doses of T 4 or T 3 , and will require either prolonged administration or higher single doses of thyroid hormone.

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“…19 Besides, there was slight but significant ethnic differences in serum TSH concentrations, which should also be taken into account while screening for thyroid hormones in pregnant women. 13,20 Black and Asian women have TSH values that are on average 0.4 mIU/ L lower than in white women; these differences persist during pregnancy. 20,21,22 Pregnant women of Moroccan, Turkish, or Surinamese descent residing in the Netherlands, have TSH values 0.2-0.3 mIU/L lower than Dutch women throughout pregnancy.…”

Section: Discussionmentioning

confidence: 97%

“…13,20 Black and Asian women have TSH values that are on average 0.4 mIU/ L lower than in white women; these differences persist during pregnancy. 20,21,22 Pregnant women of Moroccan, Turkish, or Surinamese descent residing in the Netherlands, have TSH values 0.2-0.3 mIU/L lower than Dutch women throughout pregnancy. 21 Kumar and associates found that mean T 4 levels began to rise from 16.45 pmol/L in the first trimester to 16.58 pmol/L in the second trimester and then decreased in the third trimester to 15.99 pmol/L, they also reported that mean TSH level also rise progressively through the three trimesters of pregnancy from 1.20 mlU/ L in the first trimester to 2.12 mIU/L in the second trimester and further to 3.30 mIU/L in the third trimester of pregnancy, which was not consistent with this study findings.…”

Section: Discussionmentioning

confidence: 97%

Screening of Thyroid Function in the First Half of Pregnancy

Tania¹,

Islam

2016

Bangladesh J Obstet Gynaecol

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Objective: The study was conducted to find out any alterations in thyroid function status in first half of pregnancy (up to 20 weeks), with ultimate aim of deciding the usefulness of routine screening of thyroid function in pregnancy.Material and methods: A cross-sectional study was conducted in the department of Obstetrics & Gynaecology, Dhaka Medical College and Hospital, Dhaka, Bangladesh, over a period of one year from July 2011 to June 2012 on pregnant women in their 1st half of pregnancy to screen for the thyroid function. Based on predefined eligibility criteria, a total of 230 pregnant women were purposively included in the study. Thyroid function status was assessed by measuring serum levels of TSH, free thyroxine (FT4), and free tri-iodothyronine (FT3). Women with thyroid disorders were excluded.Results: The mean age of the patients being 24 years. Over 90% of the women were housewife and majority (88.7%) was educated. Over one-quarter of women was overweight with mean body mass index being 22.1 ± 4.4 kg/m2. The women were predominantly multigravida with 56% in 1st trimester 44% in the 1st half of 2nd trimester of pregnancy (13-20 weeks). Based on trimesters specific range of serum TSH in the 1st and 1st half of 2nd trimester (13-20 weeks) of pregnancy,13% of the patients were hypothyroid and 3% were hyperthyroid thus yielding a total of 37(16%) pregnant women with abnormal thyroid function status.Conclusion: The study concluded that one in every six women may have thyroid disorder in the first half of pregnancy and subclinical hypothyroidism is four times more common than the subclinical hyperthyroidism.Bangladesh J Obstet Gynaecol, 2014; Vol. 29(1) : 26-31

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Comparison of thyroid function in pregnant and non-pregnant Asian and western Caucasian women

Cited by 63 publications

References 24 publications

Gestational changes of thyroid function and urinary iodine in thyroid antibody-negative Japanese women

Gestational changes of thyroid function and urinary iodine in thyroid antibody-negative Japanese women

Pilot study on the assessment of the setpoint of the hypothalamus–pituitary–thyroid axis in healthy volunteers

Screening of Thyroid Function in the First Half of Pregnancy

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