Comparison of Torque Teno Sus Virus (TTSuV) viral load in Porcine Circovirus Type 2 vaccinated and non-vaccinated pig herds

Whole genome sequencing and phylogenetic analysis of feline anelloviruses

“…Despite over 15 years of investigation, little is still known about the pathogenesis and possible disease associations of anellovirus infections, arising in part due to the lack of a robust cell culture (Tajiri et al, 2001;Miyamoto et al, 2000;Bando et al, 2001;Gergely et al, 2006) and pigs (Lee et al, 2012;Ritterbusch et al, 2012), nevertheless the results of all current studies are rather controversial. In our study performed on a limited set of feline samples we were not able to demonstrate a relationship between the health status of animals and TT virus infection.…”

Analysis of TTSuV1b antibody in porcine serum and its correlation with four antibodies against common viral infectious diseases

“…Moreover, it has been previously reported that T cells might be the potential target cells infected by TTSuVs (Taiwan, 2014). However, the recent studies about potential pathogenicity of TTSuVs are based on another disease model [ 5 , 9 , 10 , 19 – 23 ], in which the correlation between TTSuVs and a specific disease is determined by the load of TTSuVs in the serum or in the organs. Currently, TTSuVs has been thought to be related to PCV2 associated diseases (PCVAD).…”

“…Through comparison with related ssDNA viruses, it is assumed that the capsid protein of TTV ORF1 with a length of 1875–1884 bp is the sole protein structure [ 3 , 5 – 8 ]. TTV ORF2 has a domain similar to protein tyrosine kinase, which might be related to the regulation or replication of proteins in cells or viruses during infection period [ 9 , 10 ]. The precise function of TTV ORF3 is still elusive.…”

Torque teno sus virus 1 (TTSuV1) and 2 (TTSuV2) viral loads in serum of postweaning multisystemic wasting syndrome (PMWS)-affected and healthy pigs in Brazil

“…Thus, to define potential associations with disease, it is of importance to examine not only the viral loads of TTSuVs, but also PCV2 viral loads. Although several studies have reported on TTSuV viral loads (Aramouni et al, 2013;Brassard et al, 2010Brassard et al, , 2013Leblanc et al, 2014;Lee et al, 2012;Nieto et al, 2012;Zhang et al, 2014), the highlight of the present study is, for the first time, to compare simultaneously viral loads of both PCV2 and TTSuVs in healthy and PMWSaffected pigs. In order to address this issue, here, highly sensitive qPCRs were developed to detect and quantify TTSuV1, TTSuV2 and PCV2 viral loads.…”