Whole genome sequencing and phylogenetic analysis of feline anelloviruses

Jarošová, Veronika; Hrazdilová, Kristýna; Filipejová, Zita; Schánilec, Pavel; Celer, V.

doi:10.1016/j.meegid.2015.02.015

Cited by 11 publications

(15 citation statements)

References 27 publications

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“…Anelloviruses are not known to be pathogenic in cats and pathogenicity in other species is controversial with the exception of chicken anemia virus and porcine circovirus, which are closely related to anelloviruses. Prevalence in feline serum of 12.5-43% has been seen worldwide, which is similar to the suspected prevalence in this study (Jarosova et al, 2015;Okamoto et al, 2002;Zhu et al, 2011). To confirm the suspected higher prevalence a targeted PCR approach could be done.…”

Section: Discussionsupporting

confidence: 88%

“…Torque teno virus was the second most prevalent virus but was detected at very low coverage. Anelloviruses have been detected in cat feces, saliva and serum (Jarosova et al, 2015;Zhang et al, 2014). Anelloviruses are not known to be pathogenic in cats and pathogenicity in other species is controversial with the exception of chicken anemia virus and porcine circovirus, which are closely related to anelloviruses.…”

Section: Discussionmentioning

confidence: 99%

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A virome sequencing approach to feline oral squamous cell carcinoma to evaluate viral causative factors

Chu

Wylie

et al. 2020

Veterinary Microbiology

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Feline oral squamous cell carcinoma (FOSCC) may be the best naturally-occurring model of human head and neck squamous cell carcinoma (HNSCC). HNSCC can be broadly divided into human papillomavirus (HPV)negative cancers and HPV-positive cancers where HPV is the causative agent. Previous studies in FOSCC have used both species-specific and species-nonspecific PCR primers that may be insensitive to the detection of PVs and other viruses that may be divergent from known sequences. ViroCap is a targeted capture and next generation sequencing tool that was designed to identify all known vertebrate DNA and RNA viruses. In this study we used a metagenomic approach using ViroCap for DNA viruses in 20 FOSCC, 9 normal feline oral mucosal, and 8 suspected PV positive control samples. We tested the hypothesis that viruses would be enriched in FOSCC compared to normal oral mucosa. The virome of the FOSCC and normal feline oral mucosa consisted of feline foamy virus in 7/20 and 2/9 (35% and 22%), feline torque teno virus in 2/20 and 0/9 (10% and 0%), alphaherpesvirus in 2/10 and 0/9 (10% and 0%), FIV (0% and 22%), Epstein-Barr virus in 1/20 and 0/9 (5% and 0%) and feline papillomavirus in 1/20 and 0/9 samples (5% and 0% respectively). Felis catus papillomavirus-3 was found in 1 of 20 FOSCC samples. A virus was not associated consistently with FOSCC. If PVs have a role in FOSCC it is at most a supplementary or uncommon role. FOSCC appears most closely related to HPV-negative HNSCC. Future research on FOSCC should focus on identifying genetic and environmental causes. (S. Chu). Veterinary Microbiology 240 (2020) 108491 0378-1135/ Published by Elsevier B.V.T

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

A virome sequencing approach to feline oral squamous cell carcinoma to evaluate viral causative factors

Chu

Wylie

et al. 2020

Veterinary Microbiology

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“…Phylogenetic analysis based on the amino acid sequences of ORF1 of feline anelloviruses available in GenBank revealed that these known feline anellovirus clustered together and were classified into two species, Torque teno felis virus 1 (FcTTV1) and Torque teno felis virus 2 (FcTTV2), belonging to the genus Etatorquevirus within the family Anelloviridae [13]. The aim of this study is to characterize the genome sequence of a divergent feline anellovirus which is present in the fecal and blood samples from domestic cats with diarrhea.…”

Section: Resultsmentioning

confidence: 99%

Identification and genomic characterization of a novel species of feline anellovirus

Zhang

Wang

et al. 2016

Virol J

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Here, a novel feline anellovirus strain (named FelineAV621 and GenBank no. KX262893) was detected in two cats with diarrhea. The complete genome of FelineAV621 is 2409 nt long with a G+C content of 56.67 %, including three open reading frames (ORFs). Phylogenetic analysis based on the amino acid sequence of the putative capsid protein (ORF1) indicated that FelineAV621 belonged to a novel anellovirus species inside a clade containing the seal anellovirus, canine TTVs, and porcine TTVs, but was distant from all the previous feline anelloviruses.

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“…Pathogenicity of this virus is unknown; the genome has been reported in 10–35% of feline samples obtained at animal hospitals. 11,23 We had designed our study to detect RNA viruses primarily. Detection of DNA viruses (parvovirus and the Torque teno felis virus) may have been related to the procedure used, in which both DNA and RNA were extracted, and the DNA was not digested before cDNA synthesis.…”

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confidence: 99%

Detection of severe fever with thrombocytopenia syndrome virus and other viruses in cats via unbiased next-generation sequencing

Momoi

Matsuu

2020

J VET Diagn Invest

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We used unbiased next-generation sequencing (NGS) to detect unknown viruses in cats. Serum or plasma samples were obtained from clinically ill cats with suspected acute viral infections. Nucleic acid was extracted from serum or plasma samples to construct a complementary DNA library for NGS. Comprehensive nucleotide sequencing analyses enabled detection of the genomes of various viruses, including the severe fever with thrombocytopenia syndrome virus, feline immunodeficiency virus, feline morbillivirus, parvovirus, and Torque teno felis virus. Our findings indicate that comprehensive nucleotide analyses of serum or plasma samples can be used to detect infections with unknown viruses in cats.

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Whole genome sequencing and phylogenetic analysis of feline anelloviruses

Cited by 11 publications

References 27 publications

A virome sequencing approach to feline oral squamous cell carcinoma to evaluate viral causative factors

A virome sequencing approach to feline oral squamous cell carcinoma to evaluate viral causative factors

Identification and genomic characterization of a novel species of feline anellovirus

Detection of severe fever with thrombocytopenia syndrome virus and other viruses in cats via unbiased next-generation sequencing

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