Comparison of tramadol/acetaminophen fixed-dose combination, tramadol, and acetaminophen in patients undergoing ambulatory arthroscopic meniscectomy

Abstract

ObjectivesPreemptive analgesia is a technique in which analgesics are administered before a surgery to provide better postoperative pain relief with fewer side effects. In this study, we aimed to compare the preemptive efficacy of tramadol/acetaminophen fixed-dose combination, tramadol, and acetaminophen in patients undergoing ambulatory arthroscopic partial meniscectomy.MethodsWe evaluated the patient records of 75 patients who underwent ambulatory arthroscopic partial meniscectomy. We divided the patients into three groups consisting of 20 patients each to equalize the groups. Group A comprised patients who were administered 37.5 mg tramadol/325 mg acetaminophen fixed-dose combination, Group B comprised patients who were administered 50 mg tramadol, and Group C comprised patients who were administered 500 mg acetaminophen. Premedication was not used in any group.ResultsThere were no significant differences between the groups in terms of age, sex, BMI, and duration of surgery and anesthesia. All patients in Group B and Group C and 17 patients in Group A required rescue analgesics in the first 6 h. Visual analog scale (VAS) was 4.75 ± 3.05 in Group B at time 0 and was 6.10 ± 1.86 in Group C in the first hour and was higher than the other groups with a statistically significance (p = 0.030 and 0.020, respectively). VAS at 24 h postoperatively was ≤3 (1.60 ± 1.63, 1.55 ± 1.84 and 1.70 ± 0.65 respectively in each group), and none of the patients in any group required rescue analgesics. No major side effects, except for slight nausea in one patient requiring no medication, were noted in any group.ConclusionThe fixed-dose combination of tramadol/acetaminophen or tramadol alone is better than acetaminophen alone as a preemptive analgesic in patients undergoing ambulatory arthroscopic meniscectomy.Level of evidenceLevel III, therapeutic study.

Comparison of preemptive paracetamol, paracetamol-diclofenac & paracetamol-tramadol combination on postoperative pain after elective abdominal surgery under general anesthesia, Ethiopia: a randomized control trial study, 2018

“…This result was comparable with the result of a study done by Solmaz and Kovalak which found that significantly lower VAS in acetaminophen-tramadol combination compared to acetaminophen alone at 1st and 2nd hour (2.10 ± 1.48 Vs. 4.75 ± 3.05 p = 0.030 and 3.30 ± 1.71 Vs. 6.10 ± 1.86 0.020, respectively). The difference in VAS between the groups disappeared in the second hour (3.45 ± 1.63 Vs. 3.95 ± 1.43 p = 0.129) [29].…”

Assessment of anxiety and effect of preemptive analgesia on patients administered ambulatory anesthesia in endoscopy unit

“…The use of a multimodal approach in the management of preemptive analgesia has reduced anesthetic drug consumption, which has many side effects, but also led to more successful results in postoperative analgesia method. Solmaz and Kavalak [18] found out that combined use of parac- etamol and tramadol functions better than the use of the drugs alone in ambulatory anesthesia. Tinsbloom et al [3] pointed out that the use of opioids only for the analgesic purpose in ambulatory treatment could increase both duration of recovery and opioid addiction, but the addition of gabapentin decreased opioid use and thus shortened the recovery duration further.…”

Genotoxicity and repair capability of Mus musculus DNA following the oral exposure to Tramadol

“…Comet assay is a sensitive method in which after lysing, electrophoretic migrated DNA obtained in the thin layer of agarose and the tail is formed by extended DNA loops. These DNA loops are similar to chromatin loops as in the cell nuclei and represent the extent of DNA damage (Solmaz and Kovalak, 2018). Comet assay has been used widely for environmental monitoring, to test newly developed drugs, food additives and also used for the monitoring of DNA repair by living organisms (Ali et al, 2018, Bankoglu et al, 2018, Bastaki et al, 2017).…”