Comparison of twice-daily cefadroxil with four-times-daily cephalexin in paediatric respiratory infections

Windorfer, A; Trujillo, Hugo; Bauer, P

doi:10.1093/jac/10.suppl_b.93

Cited by 6 publications

(1 citation statement)

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“…dosing schedule [7][8][9]. Phar macokinetic studies indicate that cefa droxil has a serum half-life approximately twice that of penicillin V and other orally administered cephalosporins [10,11], in addition to having high serum, tissue, and urine levels, low protein binding, and ab sorption unaffected by the ingestion of food.…”

Section: Introductionmentioning

confidence: 99%

Clinical Comparison of Once-Daily Cefadroxil and Thrice-Daily Cefaclor in the Treatment of Streptococcal Pharyngitis

Randolph¹

1988

Chemotherapy

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The efficacy of cefadroxil once daily and cefaclor given 3 times daily was compared in 250 pediatric patients with group A β-hemolytic streptococcal pharyngitis. The duration of the therapy was 10 days. Therapeutic response was based on clinical responses at 24 h and 10 days and throat cultures on days 14, and 21 or 28. Five (5%) cefa-droxil-treated patients and 12 (12%) cefaclor-treated patients were still culture-positive on day 14. When the patients were stratified according to major differences between treatment groups observed at baseline, a significant difference between the treatment groups in favor of cefadroxil was found on day 14 (p = 0.020) and days 21–28 (p = 0.043). These data were confirmed by the clinical findings; failure or clinical recurrence occurred in 4.6% of cefadroxil-treated patients versus 22.1 % of cefaclor-treated patients. The patients complied with the recommended drug regimen, and none experienced any significant drug-related adverse reactions. The results of this study indicate that cefadroxil given once daily for streptococcal pharyngitis is an effective and well-tolerated antimicrobial agent, and suggest that the desirable pharmacokinetic properties of cefadroxil contribute to this efficacy.

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Section: Introductionmentioning

confidence: 99%

Clinical Comparison of Once-Daily Cefadroxil and Thrice-Daily Cefaclor in the Treatment of Streptococcal Pharyngitis

Randolph¹

1988

Chemotherapy

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Oral Cephalosporins in Perspective

Smith

1990

DICP

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Oral cephalosporins, after 25 years of use, continue to present the clinician with a therapeutic challenge. The older agents have been extensively prescribed for ambulatory adult and pediatric patients with a wide variety of infections caused by gram-positive and some gram-negative organisms. The newer agents, cefaclor, cefuroxime axetil, and cefixime, have increased in vitro activity against beta-lactamase-secreting strains of Haemophilus influenzae and Branhamella catarrhalis which has made them more popular for the treatment of otitis media and respiratory tract infections in children. The new agents are also more active against most gram-negative organisms. However, clinical trials have failed to show a clear-cut superiority over older, proven therapy when used to treat infections of the respiratory tract, middle ear, skin and soft tissue, urinary tract, and bone and joints when caused by sensitive organisms. Published reports of clinical trials continue to support the recommendation that oral cephalosporins, especially the newer and more expensive agents, be reserved for second- or third-line therapy when amoxicillin, penicillin V, or trimethoprim/sulfamethoxazole have either failed or produced patient intolerance. Erthromycin/sulfisoxazole and amoxicillin/clavulanate potassium are equally efficacious and also less expensive than cefaclor, cefuroxime axetil, and cefixime and could be considered second-line therapy prior to the use of the newer cephalosporins for infections in the ambulatory patient.

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Cefadroxil

Tanrisever¹,

Santella²

1986

Drugs

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Comparison of twice-daily cefadroxil with four-times-daily cephalexin in paediatric respiratory infections

Cited by 6 publications

References 0 publications

Clinical Comparison of Once-Daily Cefadroxil and Thrice-Daily Cefaclor in the Treatment of Streptococcal Pharyngitis

Clinical Comparison of Once-Daily Cefadroxil and Thrice-Daily Cefaclor in the Treatment of Streptococcal Pharyngitis

Oral Cephalosporins in Perspective

Cefadroxil

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