Comparison of two <i>in vitro</i> antifungal sensitivity tests and monitoring during therapy of <i>Sporothrix schenckii sensu stricto</i> in Malaysian cats

Han, Hock Siew; Kano, Rui; Chen, Charles; Noli, Chiara

doi:10.1111/vde.12417

Cited by 21 publications

(25 citation statements)

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“…5). This clinical finding is consistent with thermotolerability studies done on feline isolates of S. s. sensu stricto from Malaysia where up to 82% of isolates were not thermotolerant [3]. If nasal passages are affected, extracutaneous signs such as sneezing, dyspnoea and respiratory distress are commonly reported in tandem with cutaneous manifestations [24,25].…”

Section: And 4)supporting

confidence: 87%

“…It is currently recognized as a species complex consisting of Sporothrix brasiliensis, Sporothrix schenckii sensu stricto, Sporothrix globosa and Sporothrix luriei, united on the fact that they are all able to express increased virulence towards mammals (clinical clade), compared with mildly pathogenic species such as Sporothrix mexicana and Sporothrix pallida that is commonly associated with the environment (environmental clade) [1]. In veterinary medicine, S. brasiliensis, S. s. sensu stricto, S. globosa and S. pallida have been documented to cause of disease in cats, while only S. brasiliensis has been incriminated to cause clinical sporotrichosis in dogs [2][3][4][5][6][7][8]. The disease is historically referred to as 'Rose Gardeners disease', as the most common route of infection is often traced to the inoculation of conidia into broken skin via contaminated soil or plants during horticultural activities.…”

Section: Introductionmentioning

confidence: 99%

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Feline sporotrichosis in Asia

Han¹,

Kano

2020

Braz J Microbiol

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Sporothrix schenckii sensu lato is currently recognized as a species complex with only Sporothrix brasiliensis, Sporothrix schenckii sensu stricto, Sporothrix globosa and Sporothrix pallida identified to cause disease in the cat. Feline sporotrichosis in Asia is mainly reported from Malaysia where a single clonal strain of clinical clade D, Sporothrix schenckii sensu stricto manifesting low susceptibility to major antifungal classes, has been identified as the agent of the disease. Sporothrix globosa has been identified to cause disease from a single cat in Japan while the specific species of agent has not been identified yet for the disease in Thailand. Despite efforts to elucidate and describe the pathogenicity of the agent and the disease it causes, the paucity of data highlights the need for further molecular epidemiological studies to characterize this fungus and the disease it causes in Asia. Its prognosis remains guarded to poor due to issues pertaining to cost, protracted treatment course, zoonotic potential and low susceptibility of some strains to antifungals.

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Section: And 4)supporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Feline sporotrichosis in Asia

Han¹,

Kano

2020

Braz J Microbiol

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“…Cases of feline sporotrichosis have been documented in Malaysia, and studies conducted the characterisation of these isolates. However, the clinical and epidemiological characteristics of the cats have been poorly explored ( Kano et al 2015 , Han et al 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Feline sporotrichosis: associations between clinical-epidemiological profiles and phenotypic-genotypic characteristics of the etiological agents in the Rio de Janeiro epizootic area

Boechat

Oliveira

Almeida‐Paes

et al. 2018

Mem. Inst. Oswaldo Cruz

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BACKGROUNDSporotrichosis is caused by species of the genus Sporothrix. From 1998 to 2015, 4,703 cats were diagnosed at the Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil. Even after the description of the Sporothrix species, the characterisation of feline isolates is not performed routinely.OBJECTIVESTo characterise the clinical isolates from cats at the species level and correlate them with the clinical and epidemiological characteristics of the cats.METHODSForty seven Sporothrix spp. isolates from cats assisted at Fiocruz from 2010 to 2011 were included. Medical records were consulted to obtain the clinical and epidemiological data. The isolates were identified through their morphological and physiological characteristics. T3B polymerase chain reaction (PCR) fingerprinting was used for molecular identification of the species.FINDINGSIn phenotypic tests, 34 isolates were characterised as S. brasiliensis, one as S. schenckii and 12 as Sporothrix spp. PCR identified all isolates as S. brasiliensis.MAIN CONCLUSIONS S. brasiliensis is the only etiological agent of feline sporotrichosis in Rio de Janeiro to date. None association was found between the isolates and the clinical and epidemiological data. In addition, we strongly recommend the use of molecular techniques for the identification of isolates of Sporothrix spp.

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“…Five cats with myiasis in this study were concurrently diagnosed with sporotrichosis, another disease commonly associated with cat fights and infection has been reported in Malaysia. It is not surprising that both diseases would share the same predisposed anatomical sites, as both diseases share the same common underlying predisposing cause of fighting …”

Section: Discussionmentioning

confidence: 99%

“…Feline sporotrichosis is a disease known to be present in Malaysia and also is commonly associated with cat fights amongst intact male cats; however, no studies have examined the possible association between sporotrichosis and screw‐worm myiasis . The objectives of the present study were to highlight some epidemiological and clinical aspects of cutaneous screw‐worm myiasis in dogs and cats in various parts of Malaysia.…”

Section: Introductionmentioning

confidence: 99%