Comparison of two iodine-125 brachytherapy implant techniques for the treatment of lung tumor: Preplanning and intraoperative planning

Li, Ranran; Zhang, Ying; Yuan, Yuan; Qi, Lin; Dai, Jianjian; Xu, Ruicai; Baocheng, Geng; Han, Mingyong

doi:10.1016/j.brachy.2018.08.007

Cited by 6 publications

(6 citation statements)

References 26 publications

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“…Then, clinical target volume (CTV) was generated by adding a margin of 5-mm to gross tumor volume (GTV) in all directions. The CTV was equal to the target volume [12,13,14]. We outlined a 2-mm thick contour below the skin surface standing for skin [15].…”

Section: Methodsmentioning

confidence: 99%

Subdermal injection of hyaluronic acid to decrease skin toxicity from radiation delivered with low-dose-rate brachytherapy for cancer patients

Yuan

Zhang

Dai

et al. 2019

jcb

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To study the feasibility of hyaluronic acid (HA) injection to increase the distance between skin and radioactive sources, and dose reduction of skin during low-dose-rate (LDR) brachytherapy. Material and methods: A total of 11 patients with subdermal malignant tumors were enrolled in this study. HA was injected after I-125 seed implantation, and dosimetric parameters were calculated by a brachytherapy treatment planning system (BTPS). The distance of the new space between radioactive sources and skin was measured on computed tomography (CT) and magnetic resonance imaging (MRI). Clinical signs were observed and followed up for every patient. Results: After HA injection, the average of newly generated maximum distance was 1.0 cm along the entire length of the tumor. The D 90 and V 100 did not significantly change for tumors before or after injection (p = 0.39, p = 0.50, respectively). The maximum dose to a relatively small volume (0.1 cc) of the skin (OAR-Max) decreased from 100.66 Gy to 61.20 Gy (p < 0.05), and the mean skin dose (OAR-Mean) decreased from 49.20 Gy to 17.27 Gy (p < 0.05) after injection. On follow-up CT and MRI, HA was quite stable in shape and position for nearly 6 months. Conclusions: Our study results showed that an additional 1.0 cm distance between the radioactive source and skin could be induced by HA injection in patients with subdermal tumor, and this distance could significantly decrease the skin dose in LDR brachytherapy. In addition, no obvious toxicity and side effects were produced by HA injection. Therefore, hyaluronic acid injection is a safe and effective technique.

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Section: Methodsmentioning

confidence: 99%

Subdermal injection of hyaluronic acid to decrease skin toxicity from radiation delivered with low-dose-rate brachytherapy for cancer patients

Yuan

Zhang

Dai

et al. 2019

jcb

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“…They suggested that V100, V150, and V200 for the intraoperative planning technique were significantly higher than that for the preplanning technique (95.65% vs. 88.86%, 76.47% vs. 69.23%, and 59.80% vs. 28.30%, respectively, p < 0.01). In addition, intraoperative planning had a significantly higher coverage index, conformity index plan, and quality index (p < 0.05) and a lower dose homogeneity index compared with the preplanning technique ( 49 ). When it comes to the improved accuracy brought by 3D-PT, Liu et al.…”

Section: Physical Aspectsmentioning

confidence: 99%

“…For instance, Li et al. ( 49 ) reported that intraoperative planning was superior to the preplanning technique, via comparing the difference of dosimetry parameter between preplanning and intraoperative planning in I-125 BT for lung cancer. They suggested that V100, V150, and V200 for the intraoperative planning technique were significantly higher than that for the preplanning technique (95.65% vs. 88.86%, 76.47% vs. 69.23%, and 59.80% vs. 28.30%, respectively, p < 0.01).…”

Section: Physical Aspectsmentioning

confidence: 99%

Radioactive Iodine-125 in Tumor Therapy: Advances and Future Directions

Wei

Mengyuan

et al. 2021

Front. Oncol.

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Radioactive iodine-125 (I-125) is the most widely used radioactive sealed source for interstitial permanent brachytherapy (BT). BT has the exceptional ability to deliver extremely high doses that external beam radiotherapy (EBRT) could never achieve within treated lesions, with the added benefit that doses drop off rapidly outside the target lesion by minimizing the exposure of uninvolved surrounding normal tissue. Spurred by multiple biological and technological advances, BT application has experienced substantial alteration over the past few decades. The procedure of I-125 radioactive seed implantation evolved from ultrasound guidance to computed tomography guidance. Compellingly, the creative introduction of 3D-printed individual templates, BT treatment planning systems, and artificial intelligence navigator systems remarkably increased the accuracy of I-125 BT and individualized I-125 ablative radiotherapy. Of note, utilizing I-125 to treat carcinoma in hollow cavity organs was enabled by the utility of self-expandable metal stents (SEMSs). Initially, I-125 BT was only used in the treatment of rare tumors. However, an increasing number of clinical trials upheld the efficacy and safety of I-125 BT in almost all tumors. Therefore, this study aims to summarize the recent advances of I-125 BT in cancer therapy, which cover experimental research to clinical investigations, including the development of novel techniques. This review also raises unanswered questions that may prompt future clinical trials and experimental work.

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“… 24 Additionally, intraoperative planning methods were more effective than pre-planning methods for treating lung tumors, as demonstrated by comparing V 100 , V 150 , V 200 , CI, COIN, plan quality index, and HI. 25 However, comparing 125 I seed implantation therapy and external radiotherapy is challenging because it is difficult to accurately convert the absorbed dose of brachytherapy into that of external radiotherapy.…”

Section: Basics and Principles Of 125 I Seed Impla...mentioning

confidence: 99%