Comparison of Two Methods of Long Bone Fracture Repair in Rabbits

Barron, Heather W.; McBride, Michael; Martinez-Jimenez, David; Foutz, T. L.; Divers, Stephen J.; Budsberg, Steven C.

doi:10.1053/j.jepm.2010.06.004

Cited by 16 publications

(20 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…While in this retrospective study there was no randomisation of treatment choice, and only small numbers of fractures were evaluated, our findings, and that of previous reports, indicate that plating of appendicular skeleton fractures in rabbits can be successful when selected in appropriate cases (Terjesen , Barron et al . , Zehnder & Kapatkin ).…”

Section: Discussionmentioning

confidence: 97%

“…However, when tested in a femoral ex vivo gap model, the complications seen with combined ESF and IMP fixation, such as fracture of the bone during pin placement or during loading, differ to those observed with bone plate fixation, which typically fail by plate bending (Barron et al . ). Rabbit bone healing was faster after plate fixation compared to ESF in an experimental model, but a reduction in bone strength secondary to plate‐induced stress‐protection was observed between 6 and 12 weeks postoperatively (Terjesen ).…”

Section: Discussionmentioning

confidence: 97%

“…) and ex vivo studies (Terjesen , Barron et al . ). The aetiology, characteristics, treatment and outcome of fractures in a large cohort of small‐breed rabbits (≤3.0 kg) at a single institution has recently been published reporting that treatment with external skeletal fixation (ESF) resulted in the majority of fractures healing (Sasai et al .…”

Section: Introductionmentioning

confidence: 97%

“…A variety of surgical fixation methods have been described including external coaptation, ESF, intramedullary pinning (IMP), pins and rigid internal fixation (mainly screws and bone plates) (Barron et al . , Ciwko et al . , Harcourt‐Brown & Langley‐Hobbs , Langley‐Hobbs & Harcourt‐Brown , Pead & Carmichael , Rich , Sasai et al .…”

Section: Introductionmentioning

confidence: 99%

“…The lack of evidence-based guidance for the treatment and outcome of rabbit fractures is well recognised . Recommendations for fracture management in rabbits are often based on clinical experience (Zehnder & Kapatkin 2012, individual case reports (Pead & Carmichael 1989, Ciwko et al 2018 and ex vivo studies (Terjesen 1984a, Barron et al 2010. The aetiology, characteristics, treatment and outcome of fractures in a large cohort of small-breed rabbits (≤3.0 kg) at a single institution has recently been published reporting that treatment with external skeletal fixation (ESF) resulted in the majority of fractures healing (Sasai et al 2015(Sasai et al , 2018.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Presentation, treatment and outcome of long‐bone fractures in pet rabbits (Oryctolagus cuniculus)

Garcia-Pertierra

Ryan

Richardson

et al. 2019

J of Small Animal Practice

View full text Add to dashboard Cite

Objectives To describe the incidence, aetiology, characteristics, assessment, management and outcome of long‐bone fractures in rabbits presenting to a single institution. Materials and Methods Medical records of pet rabbits diagnosed with long‐bone fractures over a 12‐year period were analysed. Patient signalment, fracture aetiology, fracture location, fracture description, time from fracture occurrence to veterinary presentation, fixation method, postoperative complications, clinical outcome and follow‐up were recorded. Results Twenty‐eight pet rabbits that sustained 30 fractures were included in the study [femoral (n=12), tibial (n=6), metacarpal/metatarsal/phalangeal (n=5), radial and ulnar (n=4) and tarsal (n=3)]. Twenty‐one (75%) of the rabbits were less than 2 years of age, including seven (25%) under 6 months of age. Twenty‐five fractures had no identifiable cause and five were traumatic. Only one fracture was open. Surgical stabilisation was performed in 22 fractures, four were non‐surgically managed, two had the affected limb amputated, one underwent digital amputation and one was euthanased. Postoperative complications occurred in nine fractures [major (n=6), minor (n=3)]. The frequency of complications or attainment of a functional recovery was not notably different between the different methods of fixation. Overall, 24 rabbits recovered, two were euthanased and four underwent limb amputation. Clinical Significance Fractures in rabbits typically occur in young animals and they usually lack an obvious aetiology. The majority of the rabbits treated achieved a functional recovery, although the postoperative complication rate was high in fractures treated surgically (41%).

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Presentation, treatment and outcome of long‐bone fractures in pet rabbits (Oryctolagus cuniculus)

Garcia-Pertierra

Ryan

Richardson

et al. 2019

J of Small Animal Practice

View full text Add to dashboard Cite

show abstract

Orthopedic Surgery in Small Mammals

McFadden

2021

Surgery of Exotic Animals

View full text Add to dashboard Cite

Animal modeling in bone research—Should we follow the White Rabbit?

Macedo

Feitosa

Kawamoto

et al. 2019

Anim Models and Exp Med

View full text Add to dashboard Cite

In the long history of mankind, animals have played significant roles.We owe much of our intellectual sophistication and societal status to animal husbandry. 1 Farming and agriculture have allowed humans to control their environment and an improved nutrition. The first rural settlements marked the birth of the ancient civilizations, 2 but also triggered the first zoonotic outbreaks and the beginning of public health concerns. 3 The earliest records of animal use coincide with the appearance of Hippocrates' concepts and the birth of Western medicine. 2 Jumping ahead 2400 years, in the year 2018 more than 20 000 animal subjects-exceeding 200 species-were part of translational studies worldwide, 4 in pre-clinical trials. 2 Animal modelling can provide reliable data to elucidate human diseases. 5 Despite benefiting our quality of life, animal research remains controversial. 3 There is a growing sense of disapproval over using household pets in experiments. 1 New technologies have been created to replace animals in research, but the position of ideal bone substitute remains open. 6 Thus, primary research on novel models continues paramount. 7 AbstractAnimal models are live subjects applied to translational research. They provide insights into human diseases and enhance biomedical knowledge. Livestock production has favored the pace of human social development over millennia. Today's society is more aware of animal welfare than past generations. The general public has marked objections to animal research and many species are falling into disuse. The search for an ideal methodology to replace animal use is on, but animal modeling still holds great importance to human health. Bone research, in particular, has unmet requirements that in vitro technologies cannot yet fully address. In that sense, standardizing novel models remains necessary and rabbits are gaining in popularity as potential bone models. Our aim here is to provide a broad overview of animal modeling and its ethical implications, followed by a narrower focus on bone research and the role rabbits are playing in the current scenario. K E Y W O R D Sanimal experimentation, bone density, Lagomorpha, translational medical research MACEDO Et Al.

show abstract

Comparison of Two Methods of Long Bone Fracture Repair in Rabbits

Cited by 16 publications

References 7 publications

Presentation, treatment and outcome of long‐bone fractures in pet rabbits (Oryctolagus cuniculus)

Presentation, treatment and outcome of long‐bone fractures in pet rabbits (Oryctolagus cuniculus)

Orthopedic Surgery in Small Mammals

Animal modeling in bone research—Should we follow the White Rabbit?

Contact Info

Product

Resources

About