Comparison of two nonlinear registration techniques to investigate brain atrophy patterns in normal aging

Pu, Fang; Xu, Liqiang; Li, Deyu; Fan, Yubo; Huang, Niu; Li, Shuyu

doi:10.1016/j.neurad.2013.01.004

Cited by 3 publications

(3 citation statements)

References 36 publications

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“…Its nonlinear registration and segmentation methods, jointly implemented in a unified framework (Ashburner and Friston 2005;Pohl et al 2005), have been successfully used in numerous investigations (Dewey et al 2010;Colloby et al 2011;Izquierdo-Garcia et al 2014). Several comparative studies have been conducted to examine the accuracy of SPM12 on MR images collected in young individuals (Wilke et al 2002;Klein et al 2009;Han et al 2012;Martino et al 2013;Pu et al 2013), but not yet in elderly populations. There is however a general consensus on the fact that age-related and pathological changes have a negative impact on the performance of the method adopted (Dade et al 2004;Hoeksma et al 2005;Allen et al 2008;Kennedy et al 2009;Peelle et al 2012;Eloyan et al 2014).…”

Section: Introductionmentioning

confidence: 99%

A Spatial Registration Toolbox for Structural MR Imaging of the Aging Brain

Ganzetti

Liu²,

Mantini

et al. 2018

Neuroinform

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During aging the brain undergoes a series of structural changes, in size, shape as well as tissue composition. In particular, cortical atrophy and ventricular enlargement are often present in the brain of elderly individuals. This poses serious challenges in the spatial registration of structural MR images. In this study, we addressed this open issue by proposing an enhanced framework for MR registration and segmentation. Our solution was compared with other approaches based on the tools available in SPM12, a widely used software package. Performance of the different methods was assessed on 229 T1-weighted images collected in healthy individuals, with age ranging between 55 and 90 years old. Our method showed a consistent improvement as compared to other solutions, especially for subjects with enlarged lateral ventricles. It also provided a superior inter-subject alignment in cortical regions, with the most marked improvement in the frontal lobe. We conclude that our method is a valid alternative to standard approaches based on SPM12, and is particularly suitable for the processing of structural MR images of brains with cortical atrophy and ventricular enlargement. The method is integrated in our software toolbox MRTool, which is freely available to the scientific community.

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Section: Introductionmentioning

confidence: 99%

A Spatial Registration Toolbox for Structural MR Imaging of the Aging Brain

Ganzetti

Liu²,

Mantini

et al. 2018

Neuroinform

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“…In addition, spatial normalization of brain MRI, particularly in the presence of pathological tissue, is significantly challenging due to atypically disrupted anatomy (atrophy) and tissue contrast (partial volume effect). Although the accuracy of the SPM DARTEL was successfully validated to normalize PET and MRI for voxel‐wise analysis , this normalization cannot guarantee perfect registration over the whole brain. In fact, we observed that the deformation was quite accurate at deep structures such as major association tracts, but not as accurate in subcortical, peripheral regions where atrophy and partial volume effect likely exist.…”

Section: Discussionmentioning

confidence: 99%

“…All children had additional native and postcontrast MRI sequences to establish the diagnosis of SWS and to study the extent of brain involvement. Also, all SWS children underwent interictal FDG‐PET scanning using an EXACT/HR PET scanner (CTI/Siemens, Hoffman Estates, IL), which provides simultaneous acquisition of 47 contiguous transaxial images (nominal resolution = 1.76 mm) with slice thickness of 3.13 mm . Intravenous injection of 5.29 MBq/kg of FDG was followed by a 30‐minute uptake period.…”

Section: Methodsmentioning

confidence: 99%

Assessment of brain damage and plasticity in the visual system due to early occipital lesion: Comparison of FDG‐PET with diffusion MRI tractography

Jeong

Tiwari

Shin

et al. 2014

Magnetic Resonance Imaging

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Purpose To determine the relation between glucose metabolic changes of the primary visual cortex, structural abnormalities of the corresponding visual tracts, and visual symptoms in children with Sturge-Weber syndrome (SWS). Materials and Methods In 10 children with unilateral SWS (ages 1.5–5.5 years), a region-of-interest analysis was applied in the bilateral medial occipital cortex on positron emission tomography (PET) and used to track diffusion-weighted imaging (DWI) streamlines corresponding to the central visual pathway. Normalized streamline volumes of individual SWS patients were compared with values from age-matched control groups as well as correlated with normalized glucose uptakes and visual field deficit. Results Lower glucose uptake and lower corresponding streamline volumes were detected in the affected occipital lobe in 9/10 patients, as compared to the contralateral side. Seven of these 9 patients had visual field deficit and normal or decreased streamline volumes on the unaffected side. The two other children had no visual symptoms and showed high contralateral visual streamline volumes. There was a positive correlation between the normalized ratios on DWI and PET, indicating that lower glucose metabolism was associated with lower streamline volume in the affected hemisphere (R = 0.70, P = 0.024). Conclusion We demonstrated that 18F-flurodeoxyglucose (FDG)-PET combined with DWI tractography can detect both brain damage on the side of the lesion and contralateral plasticity in children with early occipital lesions.

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