Comparison of two picosecond lasers to a nanosecond laser for treating tattoos: a prospective randomized study on 49 patients

Lorgeou, A.; Perrillat, Y.; Gral, N.; Lagrange, S.; Lacour, Jean‐Philippe; Passeron, Thierry

doi:10.1111/jdv.14492

Cited by 42 publications

(42 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The pathogenesis of melasma is multifactorial and complicated, and the therapeutic modality should target not only melanin but also photoaging and dermal inflammation. A novel 755‐nm picosecond (ps) alexandrite laser has shown promising results in tattoo and pigmented lesions . With an extremely short pulse duration of 550–750 ps, this laser produces a mainly photomechanical and less photothermal effect, which causes pigment fragmentation while simultaneously minimizing collateral thermal damage and inflammation to the surrounding tissue .…”

Section: Introductionmentioning

confidence: 99%

“…A novel 755nm picosecond (ps) alexandrite laser has shown promising results in tattoo and pigmented lesions. 16,17 With an extremely short pulse duration of 550-750 ps, this laser produces a mainly photomechanical and less photothermal effect, which causes pigment fragmentation while simultaneously minimizing collateral thermal damage and inflammation to the surrounding tissue. 18 Furthermore, a diffractive lens array (DLA), which is an innovative optical attachment for the ps laser, was developed to redistribute energy into high-density pulses, similar to the concept of a fractional laser.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prospective randomized controlled trial comparing treatment efficacy and tolerance of picosecond alexandrite laser with a diffractive lens array and triple combination cream in female asian patients with melasma

Wang

Lin

Chen

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

Background Recent evidence suggests melasma to be a photoaging disorder. Triple combination creams (TCC: fluocinolone acetonide 0.01%, hydroquinone 4% and tretinoin 0.05%) remain the gold standard treatment. Picosecond alexandrite laser treatment using a diffractive lens array (DLA) has been identified to be effective for improving photoaging conditions. Objective We aimed to compare the efficacy and tolerance of the picosecond alexandrite laser with those of DLA and TCC in female Asian patients with melasma. Methods Twenty‐nine patients were randomly assigned to group A1 (3 laser sessions at 4‐week intervals), A2 (5 laser sessions at 4‐week intervals) or B (TCC daily for at least 8 weeks and then tapered until the final evaluation). The Melasma Area, Severity Index (MASI) score and VISIA were assessed at baseline, week 12 and week 20. By week 20, the follow‐up periods for groups A1 and A2 were 3 months and 1 month, respectively. Results Nine, 11 and 6 participants in groups A1, A2 and B completed the study, respectively. MASI scores were significantly improved in all 3 groups at weeks 12 and 20. In groups A1, A2 and B, the improvement rates at week 20 were 53%, 38% and 50%, respectively. VISIA® analysis additionally revealed a significant improvement in spots, porphyria, pores and brown spots after 3 laser sessions (P < 0.05). Group A2 showed greater improvements than group A1 in terms of spots, wrinkles and pores; however, only red areas were significantly different (P < 0.001). All side‐effects in the 3 groups were transient and gradually subsided after 1–3 months. Conclusion Picosecond alexandrite laser treatment using DLA showed comparable efficacy with TCC for the treatment of melasma. Improvements in texture, spots, wrinkles and pores were observed in the laser groups. Patients with melasma lesions that exhibit telangiectasia may benefit from additional laser treatment sessions.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prospective randomized controlled trial comparing treatment efficacy and tolerance of picosecond alexandrite laser with a diffractive lens array and triple combination cream in female asian patients with melasma

Wang

Lin

Chen

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…The new picosecond-domain lasers not only offer shorter pulse-durations than earlier-generation, nanosecond-domain lasers, but many also offer laser-pumped lasers that deliver the three main wavelengths used to treat multicolor tattoos: 1064 nm infrared laser energy predominantly for removing black ink, 532 nm green light to remove red, yellow, and orange ink, and 755 nm red light to remove blue, green, and purple inks [16,17,[20][21][22][23][24]26,27]. The highest energy will come from the primary wavelength generated from a device, since conservation of energy dictates that there will be loss when converting from one wavelength to another.…”

Section: Introductionmentioning

confidence: 99%

“…Picosecond‐domain lasers have added to the treatment options for laser tattoo removal, joining the Q‐switched, nanosecond‐domain devices that have been the mainstay for laser tattoo removal using selective photothermolysis . The shorter pulse‐durations offered by picosecond‐domain lasers were developed to remove tattoos in fewer treatments, as compared to nanosecond‐domain devices.…”

Section: Introductionmentioning

confidence: 99%

A novel titanium sapphire picosecond‐domain laser safely and effectively removes purple, blue, and green tattoo inks

2018

View full text Add to dashboard Cite

BackgroundGreen, blue, and purple tattoo pigments are often the colors most resistant to laser removal. Recently, the first ever production picosecond‐domain laser with a 785 nm wavelength was developed to improve the rate of clearance of green, blue, and purple tattoo inks.MethodsTwenty‐two tattoos from 15 subjects with skin phototypes II–IV were enrolled in the study. A total of four treatments were administered using a single 785 nm picosecond‐domain laser wavelength. Blinded assessment of digital, cross‐polarized photographs taken approximately 8 weeks following the last treatment was performed using an 11‐point clearance scale.ResultsFourteen subjects with 21 tattoos completed all study visits. The 21 tattoos contained the following pigments: black (n = 15), green (n = 13), blue (n = 8), yellow (n = 5), purple (n = 4), and red (n = 3). Treatments were performed with a 2‐4‐mm beam diameter and fluences ranging from 1.1 to 3.1 J/cm2. Blinded assessment of photographs found 85%, 81%, 74%, 61%, 11%, and 5% clearance from baseline photos for purple, blue, green, black, red, and yellow pigments, respectively. Treatments were well tolerated with typical erythema, edema and one case of pinpoint bleeding. No scarring was noted.ConclusionThis first study of a new 785 nm picosecond‐domain laser demonstrates safe and effective removal of multicolor tattoos. Although clearance was shown for a multitude of colors including black, the 785 nm laser wavelength has special affinity to purple, blue and green tattoo pigments. Lasers Surg. Med. 50:704–710, 2018. © 2018 The Authors. Lasers in Surgery and Medicine Published by Wiley Periodicals, Inc.

show abstract

“…Indeed, a single-blind split randomized trial in 30 black professional tattoos treated with a picosecond 1064 nm neodymium-doped: yttrium aluminum (Nd : YAG) laser versus QS 1064 nm Nd : YAG found no significant difference in efficacy after two treatments (Pinto et al, 2017). In contrast, Lorgeou et al, in a more recent single-blind split randomized trial among 49 patients treated with a picosecond 1064/532 nm laser and QS 1064/532 nm laser, found the picosecond laser more effective for reducing at least 75% of tattoo color intensity (Lorgeou, Perrillat, Gral, et al, 2017). This case exemplifies the effectiveness of a triple-wavelength treatment in the ablation of a polychromatic tattoo of unknown ink and ingredients.…”

Section: Dear Editormentioning

confidence: 99%

Clearance of facial tattoo with triple-wavelength picosecond laser and fractionated carbon dioxide laser

Rivera¹,

Zaldo²,

Jauregui³

et al. 2018

Dermatologic Therapy

View full text Add to dashboard Cite

A 34-year-old Hispanic woman presented to our clinic with a 2-week history of facial tattoo with the aim of recreating the appearance of "freckles" on her face. The patient was distressed and mentioned negative impacts on personal and professional relationships. At examination, multiple small, hyperpigmented, brownish macules were noted concordant with polychromatic professional facial tattoo with the presence of a moderate amount of reddish-brown ink ( Figure 1). Therefore, triple-wavelength picosecond laser in combination with fractionated laser seems to be a safe and effective therapeutic approach in a dark-skinned patient with a tattoo localized in a cosmetically relevant area. FUNDING INFORMATIONThis study has no funding source. The authors are responsible for the accuracy of the information presented.

show abstract

Comparison of two picosecond lasers to a nanosecond laser for treating tattoos: a prospective randomized study on 49 patients

Cited by 42 publications

References 17 publications

Prospective randomized controlled trial comparing treatment efficacy and tolerance of picosecond alexandrite laser with a diffractive lens array and triple combination cream in female asian patients with melasma

Prospective randomized controlled trial comparing treatment efficacy and tolerance of picosecond alexandrite laser with a diffractive lens array and triple combination cream in female asian patients with melasma

A novel titanium sapphire picosecond‐domain laser safely and effectively removes purple, blue, and green tattoo inks

Clearance of facial tattoo with triple-wavelength picosecond laser and fractionated carbon dioxide laser

Contact Info

Product

Resources

About