Comparison of two whole-room ultraviolet irradiation systems for enhanced disinfection of contaminated hospital patient rooms

Ali, Shanom; Yui, S.; Muzslay, M.; Wilson, A.P.R.

doi:10.1016/j.jhin.2017.08.011

Cited by 17 publications

(10 citation statements)

References 12 publications

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“…Several prior studies have demonstrated reduction in environmental microbial contamination through the use of UV disinfection. [3][4][5][6] Some studies have shown a reduction in CDI rates in healthcare facilities, but these have primarily relied on historical data as a comparator. [7][8][9] This is the first time there has been a direct head-to-head comparison between patient care units in the same facility using UV disinfection in addition to the use of bleach.…”

Section: Discussionmentioning

confidence: 99%

A trial of pulsed xenon ultraviolet disinfection to reduce Clostridioides difficile infection

Sampathkumar

Folkert

Barth

et al. 2019

American Journal of Infection Control

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Background: An intervention was designed to test whether the addition of an ultraviolet (UV) disinfection step after terminal cleaning would be helpful in reducing Clostridium difficile infection (CDI) rates in a realworld situation. Methods: This study was a quasi-experimental design using 3 units as intervention units for the intervention and 3 similar units as control units. Intervention units 2 hematology and bone marrow transplant units and one medical-surgical unit at a large teaching hospital in the Midwest. UV disinfection was added after patient discharge and terminal cleaning in the intervention units. Results: At baseline, CDI rates in the intervention and control arms were similar. During the 6 months of UV disinfection, the CDI rate in the intervention units decreased to 11.2 per 10,000 patient days, compared with 28.7 per 10,000 patient days in the control units (P = .03). In addition, the intervention units also saw a reduction in vancomycin-resistant enterococci acquisition. Conclusions: The addition of UV disinfection to the terminal cleaning resulted in a reduction in CDI that has been sustained over several months 2 years.

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Section: Discussionmentioning

confidence: 99%

A trial of pulsed xenon ultraviolet disinfection to reduce Clostridioides difficile infection

Sampathkumar

Folkert

Barth

et al. 2019

American Journal of Infection Control

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“…Anderson 2018 [9] reported hospital-wide infection/acquisition using a retrospective cohort study; data not extracted Rutala 2018 [36] reported environmental sampling results using a prospective cohort study; data not extracted J o u r n a l P r e -p r o o f [17] Nagaraja 2015 [31] USA Extracted data are combined before-after comparisons for operating theatres 1 and 2; adjusted OR refers to interaction between after phase of study and combined effect of operating theatres 1 and 2 Napolitano 2015 [32] USA Ali 2017 [55] Ali, S., et al, Comparison of two whole-room ultraviolet irradiation systems for enhanced disinfection of contaminated hospital patient rooms. Journal of Hospital Infection, 2017.…”

Section: Appendix F -Included Studiesmentioning

confidence: 99%

Automated room decontamination: report of a Healthcare Infection Society Working Party

Beswick

Fry²,

Bradley

et al. 2022

Journal of Hospital Infection

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…There are three UVC range subsets that have been extensively studied as optimal for pathogen disinfection 18 , 19 : (1) 207–222 nm 13 , 20 – 22 , (2) 254 nm 23 – 26 , and (3) 260–280 nm 24 , 27 – 30 . 254 nm wavelength is the most commonly used germicidal wavelength.…”

Section: Introductionmentioning

confidence: 99%

Systematic evaluating and modeling of SARS-CoV-2 UVC disinfection

Freeman

Kibler

Lipsky

et al. 2022

Sci Rep

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The ongoing COVID-19 global pandemic has necessitated evaluating various disinfection technologies for reducing viral transmission in public settings. Ultraviolet (UV) radiation can inactivate pathogens and viruses but more insight is needed into the performance of different UV wavelengths and their applications. We observed greater than a 3-log reduction of SARS-CoV-2 infectivity with a dose of 12.5 mJ/cm2 of 254 nm UV light when the viruses were suspended in PBS, while a dose of 25 mJ/cm2 was necessary to achieve a similar reduction when they were in an EMEM culture medium containing 2%(v/v) FBS, highlighting the critical effect of media in which the virus is suspended, given that SARS-CoV-2 is always aerosolized when airborne or deposited on a surface. It was found that SARS-CoV-2 susceptibility (a measure of the effectiveness of the UV light) in a buffer such as PBS was 4.4-fold greater than that in a cell culture medium. Furthermore, we discovered the attenuation of UVC disinfection by amino acids, vitamins, and niacinamide, highlighting the importance of determining UVC dosages under a condition close to aerosols that wrap the viruses. We developed a disinfection model to determine the effect of the environment on UVC effectiveness with three different wavelengths, 222 nm, 254 nm, and 265 nm. An inverse correlation between the liquid absorbance and the viral susceptibility was observed. We found that 222 nm light was most effective at reducing viral infectivity in low absorbing liquids such as PBS, whereas 265 nm light was most effective in high absorbing liquids such as cell culture medium. Viral susceptibility was further decreased in N95 masks with 222 nm light being the most effective. The safety of 222 nm was also studied. We detected changes to the mechanical properties of the stratum corneum of human skins when the 222 nm accumulative exposure exceeded 50 J/cm2.The findings highlight the need to evaluate each UV for a given application, as well as limiting the dose to the lowest dose necessary to avoid unnecessary exposure to the public.

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Comparison of two whole-room ultraviolet irradiation systems for enhanced disinfection of contaminated hospital patient rooms

Cited by 17 publications

References 12 publications

A trial of pulsed xenon ultraviolet disinfection to reduce Clostridioides difficile infection

A trial of pulsed xenon ultraviolet disinfection to reduce Clostridioides difficile infection

Automated room decontamination: report of a Healthcare Infection Society Working Party

Systematic evaluating and modeling of SARS-CoV-2 UVC disinfection

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