Comparison of urine and bladder or urethral mucosal biopsy culture obtained by transurethral cystoscopy in dogs with chronic lower urinary tract disease: 41 cases (2002 to 2011)

Sycamore, K. F.; Poorbaugh, V. R.; Pullin, S. S.; Ward, Cynthia R.

doi:10.1111/jsap.12225

Cited by 14 publications

(10 citation statements)

References 12 publications

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“…Sensitivity testing revealed that 7 out of the 12 positive urine cultures were resistant to at least 1 commonly administered oral antibiotic. In 2 dogs, urine culture was negative; however, bladder mucosal biopsy was positive which is in disagreement with previous reports . This discrepancy might be explained by the invasion of superficial bladder epithelial cells and submucosa by bacteria, even if the isolated bacteria in our cases were not E. coli , which has been previously described in host cells with type‐1 fimbriae‐mediated invasion.…”

Section: Discussioncontrasting

confidence: 83%

“…In 2 dogs, urine culture was negative; however, bladder mucosal biopsy was positive which is in disagreement with previous reports. 13,32,33 This discrepancy might be explained by the invasion of superficial bladder epithelial cells and submucosa by bacteria, 34 even if the isolated bacteria in our cases were not E. coli, which has been previously described in host cells with type-1 fimbriae-mediated invasion. Even if this was present in a small number of dogs, we recommend urine culture and bladder mucosal biopsy culture in dogs undergoing cystoscopy for RUTI.…”

Section: Histopathologymentioning

confidence: 48%

“…13,19 The most prevalent bacteria after E. coli was Staphylococcus and Enterococcus as in 3 retrospective case studies. 2,27,32 In our culture results, a single pathogen was present in 92% of dogs, with 2 pathogens isolated in only 1 urine sample. Sensitivity testing revealed that 7 out of the 12 positive urine cultures were resistant to at least 1 commonly administered oral antibiotic.…”

Section: Histopathologymentioning

confidence: 63%

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Transurethral cystoscopy in dogs with recurrent urinary tract infections: Retrospective study (2011‐2018)

Llido

Vachon

Dickinson

et al. 2020

Veterinary Internal Medicne

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Background Urinary tract infections (UTIs) are common in female dogs and recurrent infections often require investigation by transurethral cystoscopy. Hypothesis/Objectives Describe the findings of transurethral cystoscopy in dogs presented for recurrent urinary tract infections (RUTI). Animals Fifty‐three client‐owned dogs with RUTI were included in the study. Methods Retrospective study. Data collected from medical records included signalment, clinical findings, bladder wall culture, cystoscopic, and histopathologic findings. UTI was defined as: presence of compatible clinical signs and at least 2 out of 3 of the following criteria: (1) pyuria, (2) positive urine culture, (3) resolution of clinical signs with antibiotic treatment. Recurrence of UTI was defined as at least 2 episodes of UTI within 6 months or at least 3 or more in 1 year. Results The mean age at presentation was 3.8 years with a majority of female dogs (48/53), 40/48 of which were spayed. Main breeds were Labrador (10/53), Australian Shepherd (4/53), and Miniature Schnauzer (3/53). A hooded vulva was noted in 33/48 of females. Transurethral cystoscopy showed anomalies in 45/53 of cases: mucosal edema (19/53), vestibulovaginal septal remnant (15/48), lymphoid follicles (8/53), short urethra (6/53), and ectopic ureter (5/53). Urine culture at the time of cystoscopy was positive in 13/49. Bladder wall edema and ulceration were the most common findings on histopathology (25/39). Conclusion and Clinical Importance RUTI occurred more frequently in spayed female dogs. Transurethral cystoscopy is useful in the diagnosis and treatment of anomalies in dogs with RUTIs.

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Section: Discussioncontrasting

confidence: 83%

Section: Histopathologymentioning

confidence: 48%

Section: Histopathologymentioning

confidence: 63%

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Transurethral cystoscopy in dogs with recurrent urinary tract infections: Retrospective study (2011‐2018)

Llido

Vachon

Dickinson

et al. 2020

Veterinary Internal Medicne

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“…Hierbei scheint es keine Rolle zu spielen, ob bei Narkoseeinleitung oder erst nach Probenentnahme bei Zystotomien prophylaktisch antimikrobiell wirksame Substanzen verabreicht werden [8]. Im Falle eines Erregernachweises im Urin ist eine mikrobiologische Untersuchung von Bioptaten oder Zystolithen scheinbar nicht notwendig, da hier hinsichtlich der Befunde eine sehr gute Übereinstimmung besteht [49].…”

Section: Lokalisation Der Harnsteineunclassified

Urethrolithiasis beim Hund – eine retrospektive Untersuchung an 83 Rüden

Thiel

Häußler

Kramer

et al. 2019

Tierarztl Prax Ausg K

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Zusammenfassung Gegenstand und Ziel Die Urethrolithiasis ist eine häufige Ursache für Harnabsatzstörungen. Ziel der retrospektiven Studie war, Fälle von Rüden zu evaluieren, bei denen Harnröhrensteine unter standardisierter Epiduralanästhesie in die Harnblase zurückverlagert wurden. Material und Methode Die Daten von 83 männlichen Hunden mit Urethrolithiasis wurden hinsichtlich klinischer Symptome, Lokalisation der Harnsteine, Anzahl der Urethrolithen, Art der bildgebenden Diagnostik und des operativen Eingriffs sowie der Ergebnisse der postoperativen Röntgenkontrollen ausgewertet. Zusätzlich erfolgte eine Auswertung der bakteriologischen Urinuntersuchungen und Steinanalysen. Alle Patienten erhielten zusätzlich zu einer Allgemeinanästhesie eine standardisierte Epiduralanästhesie. Ergebnisse Mit einer Ausnahme wurden alle der 83 Rüden wegen Harnabsatzbeschwerden vorgestellt, die bei 33 Patienten chronisch waren. In 66 Fällen ließen sich röntgendichte Konkremente in der Harnröhre nachweisen, 11-mal wurde die Diagnose Urethrolithiasis mittels sonografischer Untersuchung gestellt und bei 6 Patienten führte eine Katheterisierung mit nachfolgendem Nachweis der Harnsteine in der Harnblase zur Diagnose Urethrolithiasis. Mehr als ein Drittel der Hunde wiesen zum Vorstellungszeitpunkt ausschließlich Konkremente in der Urethra auf. Bei 44 Rüden wurden 3 oder mehr Urethrasteine diagnostiziert. Bei 77 von 83 Hunden (92,7 %) gelang es, alle Harnsteine unter Epiduralanästhesie in die Harnblase zurückzuverlagern. Neun Patienten mit röntgendichten Harnsteinen wiesen bei der postoperativen radiologischen Kontrolle residuale Konkremente auf. Schlussfolgerung Für die zuverlässige radiologische Diagnostik von Harnsteinen beim Rüden muss bedacht werden, dass sich ein nicht unerheblicher Anteil ausschließlich in der Harnröhre befindet. Das Vorliegen röntgendurchlässiger Urethrasteine kann durch sonografische Untersuchung der Harnröhre evaluiert werden, die alleinige Ultraschalluntersuchung der Harnblase reicht hier nicht aus. Eine Epiduralanästhesie sollte spätestens dann in Erwägung gezogen werden, wenn Spülversuche zur Behebung der urethralen Obstruktion erfolglos bleiben. Die postoperative radiologische Kontrolle nach Laparozystotomie hinsichtlich einer vollständigen Steinentfernung ist bei röntgendichten Urolithen auf jeden Fall anzuraten.

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“…Escherichia coli is the most common bacterial pathogen associated with UTIs in dogs, followed by Staphylococcus , Proteus , Klebsiella , and Pseudomonas species . Previous in vitro studies have demonstrated that almost all clinical E. coli and Staphylococcus pseudintermedius isolates from dogs can produce biofilms .…”

mentioning

confidence: 99%

Determination of minimum biofilm eradication concentrations of orbifloxacin for canine bacterial uropathogens over different treatment periods

Shimizu

Harada

2017

Microbiology and Immunology

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Biofilm formation can cause refractory urinary tract infections (UTIs) in dogs; however, minimum biofilm eradication concentrations (MBECs) of veterinary drugs against canine uropathogens remain to be investigated. In this study, the MBECs of orbifloxacin (OBFX), trimethoprim-sulfamethoxazole (TMS) and amoxicillin/clavulanate (ACV) over different time periods for treatment of canine uropathogenic Escherichia coli (n ¼ 10) were determined. The MBECs of OBFX for other bacterial uropathogens, including Staphylococcus pseudintermedius (n ¼ 5), Pseudomonas aeruginosa (n ¼ 5), Klebsiella pneumoniae (n ¼ 5) and Proteus mirabilis (n ¼ 5) were also determined. Minimum inhibitory concentrations (MICs) were identified for all strains by broth microdilution, and MBECs were determined at 24, 72, and 168 hr using the Calgary biofilm method. The 24 hr MBECs of OBFX, TMS and ACV for the E. coli strains were significantly higher than the MICs (P < 0.05), and the 72 and 168 hr MBECs were significantly lower than those at 24 hr (P < 0.05). In addition, the 24 hr OBFX MBECs for the four other uropathogens were significantly higher than the corresponding MICs (P < 0.05). The 72 and/or 168 hr OBFX MBECs for S. pseudintermedius, K. pneumoniae and P. mirabilis were significantly lower than the 24 hr concentrations (P < 0.05), whereas for P. aeruginosa, no significant difference was found between any of the MBECs (P > 0.05). These data indicate that the administration period and uropathogenic bacterial species are important factors affecting the efficacy of OBFX treatment of biofilm-related UTIs in dogs.

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Comparison of urine and bladder or urethral mucosal biopsy culture obtained by transurethral cystoscopy in dogs with chronic lower urinary tract disease: 41 cases (2002 to 2011)

Cited by 14 publications

References 12 publications

Transurethral cystoscopy in dogs with recurrent urinary tract infections: Retrospective study (2011‐2018)

Transurethral cystoscopy in dogs with recurrent urinary tract infections: Retrospective study (2011‐2018)

Urethrolithiasis beim Hund – eine retrospektive Untersuchung an 83 Rüden

Determination of minimum biofilm eradication concentrations of orbifloxacin for canine bacterial uropathogens over different treatment periods

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