Comparison of urological irrigating fluids containing glycine and mannitol in volunteers

Sandfeldt, Lars; Hahn, Robert G.

doi:10.1002/(sici)1097-0045(19991001)41:2<89::aid-pros3>3.0.co;2-i

Cited by 21 publications

(7 citation statements)

References 46 publications

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“…Interestingly, another volunteer study reported a dose‐dependent bias between the ethanol method and known amounts of infused fluid which has similarities to the pattern of agreement between N 2 O and ethanol reported here (15). Up to 800 ml of fluid, the ethanol method overestimated the absorbed volume by 200 ml on the average, while larger volumes were underestimated.…”

Section: Discussionsupporting

confidence: 78%

Monitoring of fluid absorption with nitrous oxide during transurethral resection of the prostate

Drobin

Hjelmqvist

Piros

et al. 2008

Acta Anaesthesiol Scand

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Section: Discussionsupporting

confidence: 78%

Monitoring of fluid absorption with nitrous oxide during transurethral resection of the prostate

Drobin

Hjelmqvist

Piros

et al. 2008

Acta Anaesthesiol Scand

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“…To label an infusion of 1000 ml of irrigating fluid ‘dangerous’ is inappropriate. This was confirmed by the results of the criticized study (2), as well as by later studies performed in a similar way (13, 14).…”

supporting

confidence: 75%

Ethics of infusing irrigating fluid

Hahn¹

2008

Acta Anaesthesiol Scand

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“…In humans, i.v. (acute) uptake of at least 20 g of glycine is required to result in toxic symptoms, and the threshold plasma glycine concentration where adverse symptoms start to develop is around 5 mM (Sandfeldt and Hahn, 1999; Hahn, 2006a,b). Typical adverse effects of glycine include visual disturbances to transient blindness, prickling and burning sensations in the face and neck, transient confusion, arterial hypotension and cardiac impairment, as well as nausea and vomiting (Sandfeldt and Hahn, 1999; Hahn, 2006a; Collins et al ., 2007).…”

Section: Clinical Application Of Glycinementioning

confidence: 99%

Glycine, a simple physiological compound protecting by yet puzzling mechanism(s) against ischaemia–reperfusion injury: current knowledge

Petrat

Boengler

Schulz

et al. 2012

British J Pharmacology

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Ischaemia is amongst the leading causes of death. Despite this importance, there are only a few therapeutic approaches to protect from ischaemia-reperfusion injury (IRI). In experimental studies, the amino acid glycine effectively protected from IRI. In the prevention of IRI by glycine in cells and isolated perfused or cold-stored organs (tissues), direct cytoprotection plays a crucial role, most likely by prevention of the formation of pathological plasma membrane pores. Under in vivo conditions, the mechanism of protection by glycine is less clear, partly due to the physiological presence of the amino acid. Here, inhibition of the inflammatory response in the injured tissue is considered to contribute decisively to the glycine-induced reduction of IRI. However, attenuation of IRI recently achieved in experimental animals by low-dose glycine treatment regimens suggests additional/other (unknown) protective mechanisms. Despite the convincing experimental evidence and the large therapeutic width of glycine, there are only a few clinical trials on the protection from IRI by glycine with ambivalent results. Thus, both the mechanism(s) behind the protection of glycine against IRI in vivo and its true clinical potential remain to be addressed in future experimental studies/clinical trials.

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Comparison of urological irrigating fluids containing glycine and mannitol in volunteers

Cited by 21 publications

References 46 publications

Monitoring of fluid absorption with nitrous oxide during transurethral resection of the prostate

Monitoring of fluid absorption with nitrous oxide during transurethral resection of the prostate

Ethics of infusing irrigating fluid

Glycine, a simple physiological compound protecting by yet puzzling mechanism(s) against ischaemia–reperfusion injury: current knowledge

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