Comparison of various stationary phases for normal-phase high-performance liquid chromatography of ethoxylated alkylphenols

Jandera, Pavel; Urbánek, Josef; Prokeš, B.; Churáček, J.

doi:10.1016/s0021-9673(01)89535-2

Cited by 46 publications

(6 citation statements)

References 22 publications

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“…The performance of a non-modified silica is higher when ethanol instead of or together with propanol is used as a mobile phase together with a non-polar hydrocarbon [61].…”

Section: Separation Mode a Normal Phase Chromatographymentioning

confidence: 99%

Analysis of Nonionic Surfactants with Polyoxyethylene Chains by High-Performance Liquid Chromatography

Miszkiewicz

Szymanowski

1996

Critical Reviews in Analytical Chemistry

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“…The performance of a non-modified silica is higher when ethanol instead of or together with propanol is used as a mobile phase together with a non-polar hydrocarbon [61].…”

Section: Separation Mode a Normal Phase Chromatographymentioning

confidence: 99%

Analysis of Nonionic Surfactants with Polyoxyethylene Chains by High-Performance Liquid Chromatography

Miszkiewicz

Szymanowski

1996

Critical Reviews in Analytical Chemistry

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“…Normal phase : A comparison of all the common stationary phases for NPLC analysis of APnEOs by Jandera demonstrated that amino‐bonded stationary phase gives the best separation of individual ethoxymers 24. Here, in an NPLC system, all the NPnEO and OPnEO oligomers were baseline separated according to the length of their ethoxy chain within 20 min (Fig.…”

Section: Resultsmentioning

confidence: 93%

One‐ and comprehensive two‐dimensional high‐performance liquid chromatography analysis of alkylphenol polyethoxylates

Marriott

2011

J of Separation Science

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High-performance liquid chromatography (HPLC) analysis of alkylphenol polyethoxylates (APnEOs) in one-dimensional (1-D) mode usually separates either the ethoxy or alkyl moiety distribution and requires different modes for adequate resolution. Simultaneous complete separation of variable ethoxymer chain lengths and variable alkyl end groups using 1-D-HPLC has not been reported and suggests that multidimensional (MDLC) or comprehensive two-dimensional liquid chromatography (LC×LC) might offer a suitable separation approach for this goal. This study compares different separation modes--normal phase LC (NPLC), reversed-phase LC (RPLC) and hydrophilic interaction chromatography (HILIC)--in terms of separation for alkyl and ethoxy distributions. RPLC provided adequate separation of octyl and nonyl APnEOs using an isocratic elution program and was selected as second dimension ((2)D) for LC×LC. NPLC offered better resolution than HILIC; however, non-polar NPLC solvent immiscibility with RPLC mobile phases leads to HILIC being chosen as first dimension ((1)D). The HILIC×RPLC system was evaluated by analysis of four APnEO mixtures. Complete simultaneous separation of APnEOs into individual oligomers, with each alkyl end group resolved, demonstrated the capability of the LC×LC method. Different descriptors and metrics for assessing system orthogonality were investigated to evaluate HILIC×RPLC performance. A relatively high dimensionality of 1.76 was demonstrated.

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“…One-Dimensional HPLC Analysis. Of all of the normal-phase packings which have been utilized to separate AE, the aminopropyl-bonded stationary phases have been shown to give the best separation of AE . The one-dimensional NPLC separations of Novel II 1412-70 and Neodol 25-12 are shown in Figure a and b, respectively.…”

Section: Resultsmentioning

confidence: 99%

One- and Two-Dimensional Chromatographic Analysis of Alcohol Ethoxylates

1998

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Two-dimensional liquid chromatography (2DLC) is anincreasingly popular technique which has the potential to provide a far more detailed separation and characterization of alcohol ethoxylates (AE) than has been shown by previously utilized separation techniques. The AE are unique in that these molecules have distributions in both alkyl and ethylene oxide chain lengths. In this paper, we compare the single-column techniques of open-tubular SFC, normal-and reversed-phase HPLC, and the multiple column technique of 2DLC in terms of the efficacy of separation and characterization of the alkyl and ethoxylate distributions in a select group of AE. The combination of normal-and reversed-phase HPLC in a 2DLC system accomplishes the simultaneous alkyl and ethylene oxide distribution analysis. The advantage of using 2DLC over one-dimensional chromatographic techniques is clearly demonstrated in the increased selectivity resulting in the ability to produce the ethylene oxide distributions of each alkyl component in an AE. In addition, 2DLC chromatograms are easier to interpret due to ordering of the chromatograms.

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Comparison of various stationary phases for normal-phase high-performance liquid chromatography of ethoxylated alkylphenols

Cited by 46 publications

References 22 publications

Analysis of Nonionic Surfactants with Polyoxyethylene Chains by High-Performance Liquid Chromatography

Analysis of Nonionic Surfactants with Polyoxyethylene Chains by High-Performance Liquid Chromatography

One‐ and comprehensive two‐dimensional high‐performance liquid chromatography analysis of alkylphenol polyethoxylates

One- and Two-Dimensional Chromatographic Analysis of Alcohol Ethoxylates

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