Comparison of various SYSADOA for the osteoarthritis treatment: an experimental study in rabbits

Permuy, María; Guede, David; López-Peña, Mónica; Muñoz, Fernando; Caeiro, J.R.; González‐Cantalapiedra, Antonio

doi:10.1186/s12891-015-0572-8

Cited by 23 publications

(28 citation statements)

References 63 publications

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“…Regarding histological synovial membrane assessment, we observed that risedronate administration did not present a significant efficacy in the pathological changes evaluated. However, we noticed a slightly anti-inflammatory activity as previously published in early stages of OA (24,60).…”

Section: Discussionsupporting

confidence: 82%

“…Some authors observed an improved trabecular bone volume, number, and thickness with BP administration compared to those of untreated groups (13,14,19,23,65). In the specific case of risedronate, a positive effect was noted, preserving subchondral bone properties in short-term administrations in a rabbit model of OA (23,25,60). Nevertheless, in our case, risedronate administration did not seem to preserve trabecular bone mass, exhibited decrease in overall bone quality with loss of vBMD, a tendency to decrease BV/TV and Tb.N, and increase Tb.Sp.…”

Section: Discussionmentioning

confidence: 99%

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No Effect of Long-Term Risedronate Use on Cartilage and Subchondral Bone in an Experimental Rabbit Model of Osteoarthritis

et al. 2020

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Osteoarthritis (OA) is the most prevalent degenerative joint disease in animals and humans. It is characterized by pain, articular cartilage damage and joint stiffness. It has been suggested that the status of the subchondral bone compartment plays an important role in the initiation and progression of OA. Bisphosphonates have been proposed as a potential disease-modifying treatment for OA, however their effectiveness is not yet clear. Twenty-four male adult New Zealand rabbits were used to evaluate the effects of risedronate on the subchondral bone quality and cartilage degradation in a long-term model of experimentally induced OA. Animals underwent an anterior cruciate ligament transection and partial medial meniscectomy or sham operation in only one knee, which was randomly chosen, using the contralateral as healthy control. Animals were divided into three groups (n = 8): untreated control group and sham surgery control group; both groups received only vehicle; and risedronate group, treated with 2.5 mg orally weekly for 24 weeks. Stifle joints were harvested and scanned using a high-resolution micro-CT to evaluate the subchondral plate and trabecular bone changes. The macroscopic evaluation and histological analysis were determined using an adapted Osteoarthritis Research Society International scoring scheme to assess the cartilage degeneration. The lateral and medial femoral condyle and tibial plateau were evaluated. Additionally, the histological synovial membrane assessment was carried out. Sample analysis showed that the experimental model induced osteoarthritic changes in the operated joints, whereas in sham-operated rabbits, almost no histological changes were observed on articular cartilage surfaces. In terms of macroscopic and histological analyses, risedronate-treated animals did not show improved cartilage health compared with untreated operated rabbits, but a slightly anti-inflammatory activity was observed in the synovial membrane. Risedronate administration showed a slight tendency to increase subchondral bone plate thickness in lateral compartments but, it did not show conservation of periarticular bone and was not be able to suppress the osteophyte formation. In conclusion, long-term risedronate use did not demonstrate a positive effect Fernández-Martín et al. Long-Term Risedronate Use in Osteoarthritis on reducing the cartilage damage, and failed to prevent the subchondral bone changes and osteophytogenesis in an experimental rabbit model of OA.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

No Effect of Long-Term Risedronate Use on Cartilage and Subchondral Bone in an Experimental Rabbit Model of Osteoarthritis

et al. 2020

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“…In the present study, the decrease in subchondral bone microarchitectural parameters was associated with demineralization, which suggests subchondral bone resorption, likely as a result of the effect of HA on osteoclast activity in OA subchondral bone [ 38 ]. On the contrary, in a rabbit model of OA, Permuy et al [ 21 ] did not observe any significant subchondral bone loss following HA intra-articular injection in a OA rabbit model [ 21 ]. This discrepancy might result from the more severe induction technic (combining ACLT and meniscectomy vs. ACLT) and the later endpoint used in their study (11 vs. 6 weeks) leading to a more advanced OA and thus to the recovery of initial subchondral bone microarchitectural parameters and mineral density [ 5 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, Prince et al [ 18 ] observed in vivo osteoclast activation, leading to bone resorption. To date no clear action of HA has been depicted on bone and only few investigators have explored the effect of intra-articular HA injection on key determinants of subchondral bone microarchitecture and strength [ 19 – 21 ].…”

Section: Introductionmentioning

confidence: 99%

Chitosan in viscosupplementation: in vivo effect on rabbit subchondral bone

Rieger

Boulocher

Kaderli

et al. 2017

BMC Musculoskelet Disord

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BackgroundTo investigate the effect of intra-articular injection of Chitosan (Cs) added to hyaluronic acid (HA) on subchondral bone during osteoarthritis (OA), microarchitectural parameters and mineral density were measured in a rabbit model of early OA. A novel hybrid hydrogel adding reacetylated Cs of fungal origin to HA was compared to high molecular weight HA commercial formulation.MethodEighteen rabbits underwent unilateral anterior cruciate ligament transection (ACLT) and were divided into three groups (Saline-group, HA-group and Hybrid-group) depending on the intra-articular injection compound. Eight contralateral knees were used as non-operated controls (Contralateral-group). Micro-computed tomography was performed six weeks post-ACLT to study subchondral bone microarchitectural parameters and mineral density at an early stage of OA development.ResultsCartilage thickness mean value was reduced only in Saline-group compared to Contralateral-group. When the Hybrid-group was compared to Saline-group, subchondral bone microarchitectural parameters (trabecular thickness and trabecular bone volume fraction) were significantly changed; subchondral bone plate and trabecular bone mineral densities (bone mineral density and tissue mineral density) were reduced. When the Hybrid-group was compared to HA-group, subchondral bone microarchitectural parameters (subchondral plate thickness and trabecular thickness) and trabecular bone mineral densities (bone mineral density and tissue mineral density) were significantly decreased.ConclusionConclusion: Compared to HA alone, the novel hybrid hydrogel, constituted of Cs added to HA, enhanced microarchitectural parameters and mineral density changes, leading to subchondral bone loss in a rabbit model of early experimental OA.

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“…Результаты недавно опуб-ликованого исследования, проведенного на модели ОА у кроликов [6], показали, что лечение диацереином способно уменьшить отек и поверхностные изменения хряща, оказы-вает противовоспалительное действие на синовиальное вос-паление, а также анаболическое действие на субхондраль-ную губчатую кость. При сравнении с препаратами гиалуро-новой кислоты и хондроитина и глюкозамина сульфата от-мечено более значимое положительное влияние диацереина на воспалительный процесс в синовиальной оболочке и со-стояние субхондральной кости [7].…”

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