Comparison of venous plasma glycemia and capillary glycemia for the screening of type 2 diabetes mellitus in the Japanese-Brazilian community of Mombuca (Guatapará-SP)

Abstract

BackgroundTo identify the most appropriate cut-off points of fasting glycemia for the screening of diabetes mellitus type 2 (DM2) with the comparison of the properties of capillary glycemia (CG) and venous blood plasma glycemia (PG) in a population of Japanese origin from the community of Mombuca, Guatapará - SP, Brazil.MethodsThis was a population-based descriptive cross-sectional study conducted on a sample of 131 individuals of both genders aged 20 years or more (66.8% of the target population). CG was measured with a glucometer in a blood sample obtained from the fingertip and PG was determined by an enzymatic method (hexokinase) in venous blood plasma, after a 10-14 hour fast in both cases. Data were analyzed by the receiver operating characteristic (ROC) curve in order to identify the best cut-off point for fasting glycemia (CG and PG) for the diagnosis of DM, using the 2-hour plasma glycemia > 200 mg/dl as gold - standard.ResultsThe ROC curve revealed that the best cut-off point for the screening of DM was 110 mg/dl for CG and 105 mg/dl for PG, values that would optimize the relation between individuals with positive and false-positive results. The area under the ROC curve was 0.814 for CG (p < 0.01) and 0.836 for PG (p < 0.01).ConclusionsThe cut-off points of 105 mg/dl(5.8 mmol/l) for PG and of 110 mg/dl(6.1 mmol/l) for CG appear to be the most appropriate for the screening of DM2 in the population under study, with emphasis on the fact that the value recommended for CG is 5 mg/dl higher than that for PG, in contrast to WHO recommendations.

Comparison of Glucose Values of Blood Samples Taken in Three Different Ways

“…Measuring blood glucose is a simple, rapid, and reliable procedure, but there is still no agreement regarding whether venous blood or capillary blood (the first or second drop) should be used for testing (Palese et al, 2016). Many studies have been conducted on blood glucose measurement of capillary and venous blood using different methods (Kruijshoop et al, 2004; Kulkarni et al, 2005; Foss-Freitas et al, 2010; Lonjaret et al, 2012).…”

“…Comparison of glucose values obtained from capillary blood and venous plasma blood is a wide topic of discussion. However, it is known that according to the method used for determination and the material used, that is, capillary blood, venous blood, and serum/plasma or whole blood, the level of glucose in the blood after a few hours of fasting varies (Foss-Freitas et al, 2010). Kruijshoop, Feskens, Blaak, and Bruin (2004) detected that capillary glucose (CG) values were higher than venous blood plasma glucose (PG) values both for diabetic and normoglycemic or impaired glucose tolerance subjects in a fasting condition (Kruijshoop et al, 2004).…”

“…According to the World Health Organization (WHO; 1999), PG values were approximately 10% higher than CG values. In a study, Foss-Freitas et al (2010) compared the properties of CG and PG to identify the most appropriate cutoff points of fasting glucose for diabetes mellitus type 2. The cutoff points were detected as 105 mg/dL (5.8 mmol/L) for PG and 110 mg/dL (6.1 mmol/L) for CG and based on the fact that the value recommended for CG is 5 mg/dL higher than that for PG, in contrast to WHO recommendations.…”

Prevalence, awareness, and determinants of type 2 diabetes mellitus among commercial taxi drivers in buffalo city metropolitan municipality South Africa

“…The use of capillary glycaemia is a convenient method for diabetes diagnosis in epidemiological study. [43] In addition, our sampling strategy was not random, which is the best technique for providing an unbiased representative sample of a target population. This is because we were unable to get the sampling frame of drivers in East London.…”

Comparison of Capillary and Venous Glucose in Diabetic Patient in a Peripheral Hospital

“…Even the Yellow Springs Instrument's Blood Glucose analyzer, which is considered the reference gold standard, yields laboratory glucose results dependent on Hct when whole-blood samples are used. 12 Furthermore, if laboratory glucolysis is not inhibited in whole-blood specimens the laboratory glucose levels fall with delays in processing the specimen. 13 The method of glucose measurement used by glucometers in routine clinical use are based on either chromogenic or electrochemical reactions of the three enzymes glucose oxidase, dehydrogenase, and hexokinase.…”