Comparison of visual field progression between temporally tilted disc and nontilted disc, in patients with normal tension glaucoma

Yj, Choy; Kwun, Youngkyo; Han, Joan C.; Kee, Changwon

doi:10.1038/eye.2015.17

Cited by 11 publications

(8 citation statements)

References 27 publications

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“…Tilt ratio as a contributor to VFD progression has been still on debate. Namely, Lee et al 17 found that tilt ratio was not associated with VF progression rate, while Choy et al 18 reported there were more VFDs found in eyes with increasing tilt ratio. In our study, compared to typical glaucomatous VFD group, temporal VFD group had greater tilt ratio and its progression rate was slower.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of progressive temporal visual field defects in patients with myopia

Lee

Park

Jung

2021

Sci Rep

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Temporal visual field damage (VFD) is the common type of non-glaucomatous VF defects found in eyes with myopia. However, little is known about the factors associated with its progression. We investigated the characteristic of myopic eyes with progressive temporal VF defects. This retrospective, observational study included a total of 116 eyes: 39 eyes with temporal VFDs and an axial length greater than 24.5 mm, 77 eyes with typical glaucomatous VFDs who were followed up more than 5 years. VF progression was evaluated with Trend-based global progression analysis. In the temporal VFD group, the greater tilt ratios, the higher prevalence of β-zone peripapillary atrophy (β-PPA), the substantial increase in β-PPA were found, compared to the typical glaucomatous VFD groups (all P-values ≤ 0.001). The temporal VFD group had the slower progression than the typical glaucomatous VFD group on trend-based GPA (P = 0.047). In the multivariate linear regression analysis, the change of β-PPA area over years was related to temporal VFD progression (B, − 0.000088, P = 0.003). In conclusion, myopic eyes with the temporal VFD, which come with growing β-PPA area, should be monitored with extra caution.

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Section: Discussionmentioning

confidence: 99%

Characteristics of progressive temporal visual field defects in patients with myopia

Lee

Park

Jung

2021

Sci Rep

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“…The relationship between tilted disc and progression of glaucoma is poorly understood, especially regarding causal factors that impact it. However, it has been assumed that myopic eyes with a tilted disc reliably leads to stable progression of glaucoma compared with eyes that have a non-tilted disc after the elongation process is complete [21][22][23]. In other words, disease progression in myopic glaucoma patients with PS is more stable than those without PS.…”

Section: Discussionmentioning

confidence: 99%

Posterior staphyloma is associated with the microvasculature and microstructure of myopic eyes

Nie

Ouyang

Tang

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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Objective To investigate the microvasculature and structural characteristics of the eyes of myopic patients and their association with posterior staphyloma (PS). Methods This was a retrospective, case-control study comprising of 106 eyes from 72 individuals. Using 1:1 matching of axial length (AL) of their eyes, patients were allocated into a PS group or no posterior staphyloma (NPS) group. All patients were examined using ultra-widefield fundus imaging, optical coherence tomography angiography, and ocular biometry to acquire microvasculature and microstructure parameters. Results The anterior chamber depth (ACD) of the PS group was significantly different from that of the NPS group (3.56 mm vs 3.76 mm, P < 0.001), as was 1ens thickness (3.72 mm vs 3.57 mm, P = 0.005) and spherical equivalent (SE)(-10.11D vs -8.80D, P = 0.014). The PS group had reduced choriocapillaris flow, subfoveal choroidal thickness (SFCT), and a thinner retinal layer compared with the NPS group. No difference in retinal blood flow between the two groups was observed. The PS group exhibited a smaller disc area (15082.89 vs 17,043.32, P = 0.003) and angle α between temporal retinal arterial vascular arcades (113.29°vs 128.39°, P = 0.003), a larger disc tilt ratio (1.41 vs 1.24, P < 0.001) and parapapillary atrophy (PPA) area (13840.98 vs 8753.86, P = 0.020), compared with the NPS group. Multivariate regression analysis indicated that disc tilt ratio (P = 0.031) and SFCT (P = 0.015) were significant predictors of PS. In addition, PS (P = 0.049), AL (P = 0.003), corneal refractive power (P < 0.001), ACD (P = 0.022), relative lens position (P = 0.045), and disc area (P = 0.011) were significant predictors of SE. Conclusions PS was found to be closely linked to a reduction in choriocapillaris perfusion and anatomical abnormalities including posterior and anterior segments. Furthermore, PS exacerbated the progression of myopia.

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“…21 Interestingly, tilted discs are also associated with decreased progression of primary open-angle and normal-tension glaucoma. 22,23 It is important to correct refractive error early in these patients to prevent amblyopia in asymmetric disease. 7 Although magnetic resonance imaging (MRI) may show the optic nerve inserting obliquely into the globe, 7 neuroimaging is not usually indicated.…”

Section: Tilted Discsmentioning

confidence: 99%

Congenital Optic Nerve Anomalies

Hobbs

Winter

2016

J Pediatr Neurol

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Congenital optic nerve anomalies often lead to significant visual impairment. Their prevalence is rising with an increasing ability to diagnose and classify each specific malformation. These anomalies are associated with several neurologic, systemic, and ophthalmologic features which may predict a patient's prognosis and help physicians identify treatment plans. Here, we briefly review congenital optic nerve anomalies, their unique presentations, and clinical considerations.

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Comparison of visual field progression between temporally tilted disc and nontilted disc, in patients with normal tension glaucoma

Cited by 11 publications

References 27 publications

Characteristics of progressive temporal visual field defects in patients with myopia

Characteristics of progressive temporal visual field defects in patients with myopia

Posterior staphyloma is associated with the microvasculature and microstructure of myopic eyes

Congenital Optic Nerve Anomalies

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