Comparison of X-ray and gamma-ray dose-response curves for pink somatic mutations in Tradescantia clone 02

Underbrink, A. G.; Kellerer, Albrecht M.; Mills, Robert E.; Sparrow, A.H.

doi:10.1007/bf01331174

Cited by 23 publications

(6 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many of the current risk estimates are still based on this assumption. However, several studies have demonstrated that the RBE for X relative to ␥ radiation can actually range from 1 to 8 (Schmid et al 1974, Underbrink et al 1976, Borek et al 1983, Brenner et al 2002, Kellerer 2002, Mestres et al 2008. However, in view of the characteristic radioresistance of insect cells and the range of doses used for SIT programs, an RBE close to 1 is expected for routine irradiation procedures for SIT.…”

Section: Discussionmentioning

confidence: 94%

A New Generation of X Ray Irradiators for Insect Sterilization

Mastrangelo¹,

Parker²,

Jessup³

et al. 2010

View full text Add to dashboard Cite

Recent fears of terrorism have provoked an increase in delays and denials of transboundary shipments of radioisotopes. This represents a serious constraint to sterile insect technique (SIT) programs around the world as they rely on the use of ionizing radiation from radioisotopes for insect sterilization. To validate a novel X ray irradiator, a series of studies on Ceratitis capitata (Wiedemann) and Anastrepha fraterculus (Wiedemann) (Diptera: Tephritidae) were carried out, comparing the relative biological effectiveness (RBE) between X rays and traditional gamma radiation from 60Co. Male C. capitata pupae and pupae of both sexes of A. fraterculus, both 24-48 h before adult emergence, were irradiated with doses ranging from 15 to 120 Gy and 10-70 Gy, respectively. Estimated mean doses of 91.2 Gy of X and 124.9 Gy of gamma radiation induced 99% sterility in C. capitata males. Irradiated A. fraterculus were 99% sterile at approximately 40-60 Gy for both radiation treatments. Standard quality control parameters and mating indices were not significantly affected by the two types of radiation. The RBE did not differ significantly between the tested X and gamma radiation, and X rays are as biologically effective for SIT purposes as gamma rays are. This work confirms the suitability of this new generation of X ray irradiators for pest control programs that integrate the SIT.

show abstract

Section: Discussionmentioning

confidence: 94%

A New Generation of X Ray Irradiators for Insect Sterilization

Mastrangelo¹,

Parker²,

Jessup³

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Values of the RBE as low as 0.6 have been reported (Hendry 1972). Additionally, it is noted that the RBE decreases at low dose (Schmid, Rimpl and Bauchinger 1974) down to 0.5 at 100 rad for chromosome aberrations and down to 0.6 at 10 rad for pink somatic mutations in Tradescantia (Underbrink, Kellerer, Mills and Sparrow 1976). It is further suggested on microdosimetric grounds (Bond, Meinhold and Rossi 1977) that the effectiveness of 6OCo gamma rays might fall as low as 0.25 with respect to 250 kV, X-rays a t low dose.…”

Section: Physical and Biological Response To Low-let Radiationsmentioning

confidence: 99%

Calculated yields and slowing-down spectra for electrons in liquid water: implications for electron and photon RBE

Hamm

Wright

Katz

et al. 1978

pmb

View full text Add to dashboard Cite

Detailed Monte Carlo calculations have been carried out of slowing-down spectra and yields for a number of end-points for electrons in liquid water. These investigations were made to study differences in physical effects of different low-LET radiations and implications for RBE. Initial electron energies from 1 keV to 1 MeV were used, and all secondary electrons were followed in the computations until their energies fell below 10 eV. Though there are substantial differences in the slowingdown spectra a t energies near and above the K-shell ionisation potential of oxygen, the energyspectrum of electronsat lowerenergiesisfound to be essentially independent of the initialenergy of the primary electron. The number of eventsper unit energydeposited is also essentially independent of the primary electron energy. Based on these calculations, there appears to be little basis for ascribing differences in RBE for low. LET radiations to differences in physical effects produced by secondary electrons of low energy ( 5 1 keV).

show abstract

“…For both x rays and y rays, the dose-response curves are linear-quadratic: the linear component dominates below 100 mGy (10 rad), and there is a strong quadratic component between 100 mGy (10 rad) and 1 Gy (100 rad). In fact, the effect per gray at a dose rate of 30 pGy min-l (0.003 rad min-') or 52 mGy d-l(5.2 rad d-') approached the low dose-rate limit observed in fractionated exposures to 50 mGy (5 rad) of 137Cs y rays (Underbrink et al 1976(Underbrink et al , 1985. Hence, the effect of dose rate was studied in the strong quadratic region by selecting a total dose of 600-800 mGy (60-80 rad) and by comparing the effect per rad as a function of dose rate (Nauman et al 1975).…”

Section: Neutron Quality Factorsmentioning

confidence: 85%

“…Pink-mutant events in Tradescantia stamen hairs have provided an extremely sensitive biological end point for investigating the effects of a variety of parameters on RBE for neutrons (Nauman et al 1975, Underbrink et al 1976, Bond et al 1978, Underbrink et al 1985. This biological end point has been used to obtain quantitative data for x rays and y rays over a wide range of dose rates: 20 pGy min-' to 5 Gy min-' (0.002 to 500 rad min-I), and total dose: 0.0025-6 Gy (0.25-600 rad).…”

Section: Neutron Quality Factorsmentioning

confidence: 99%

Quality Factors

Kerr¹

1988

Health Physics

View full text Add to dashboard Cite

The quality factor, Q, is a dimensionless modifier used in converting absorbed dose, expressed in gray (or rad), to dose equivalent, expressed in sievert (or rem). The dose equivalent is used in radiation protection to account for the biological effectiveness of different kinds of radiation. The quality factor is related to both linear energy transfer (LET) and relative biological effectiveness (RBE). The RBE obtained from biological experiments depends in a complex way on the observed biological effect, the specific test organism and the experimental conditions. Judgment is involved, therefore, in the choice of Q. Questions regarding the adequacy of current Q values for neutrons were first raised in a 1980 statement by the National Council on Radiation Protection and Measurements (NCRP) and later in a 1985 statement by the International Commission on Radiological Protection (ICRP). In 1980, the NCRP alerted the technical community to the possibility of a future increase between a factor of 3 to 10 in the Q for neutrons, and in 1985, the ICRP suggested an increase by a factor of 2 in Q for fast neutrons. Both these advisory groups are now recommending essentially the same guidance with regard to Q for neutrons: an increase by a factor of 2. The Q for neutrons is based on a large, albeit unfocused, body of experimental data. In spite of the lack of focus, the data supporting a change in the neutron quality factor are substantial. However, the proposed doubling of Q for neutrons is clouded by other issues regarding its application. These issues are discussed, together with the current database for the neutron quality factor. Improvements are needed to provide better guidance with regard to both Q for neutrons and its application in radiation protection.

show abstract

Comparison of X-ray and gamma-ray dose-response curves for pink somatic mutations in Tradescantia clone 02

Cited by 23 publications

References 12 publications

A New Generation of X Ray Irradiators for Insect Sterilization

A New Generation of X Ray Irradiators for Insect Sterilization

Calculated yields and slowing-down spectra for electrons in liquid water: implications for electron and photon RBE

Quality Factors

Contact Info

Product

Resources

About