Comparison urine neutrophil gelatinase - associated lipocalin with standard parameters in monitoring activity Lupus nephritis: Class IV

Abstract

Introduction: Lupus nephritis (LN) is one of the most serious complications in the development of systemic lupus erythematosus, that can adversely affect the course and prognosis of this autoimmune disease. Therefore, monitoring the effect of applied therapy, achieving remission, or monitoring LN activity is still a great challenge for nephrologists. This study aimed to compare the urinary neutrophile gelatinase associated lipocalin (u/NGAL) with traditionally accepted parameters for LN activity to indicate the importance of its determination in these patients.
 Methods: The study group consisted of 40 patients, who were prospectively followed for a period of 4 months within three control visits to 2 months. The first group (20/40) had active LN (Group A), and the second group had LN in remission (Group B). The parameters were compared: proteins/s, albumins/s, C3, C4, anti-ds-DNA Ab, proteinuria 24h, ur.protein / creatinine ratio - Up / cre, u/NGAL (immunochemical method CMIA),GFR. 
 Results: Comparing standard parameters of disease activity and NGAL/u between groups, a statistically significant difference was obtained (p <0.001). Within Group A, comparing the parameters (X ± SD) by visits (0 : 2) for anti-ds-DNA Ab a significance of p <0.05 was obtained, for albumin / s and C3 a significance of p <0.01 was obtained, and proteinuria / 24h, Upr / Cre, u/NGAL had a significance of p <0.001. The negative correlation of u/NGAL was statistically significant at initial visit with albumin/s (p <0.01) as well as the positive correlation with proteinuria 24h and Up / cre (p <0.001). In visit 2 significant negative correlation of u/NGAL with albumin /s and C3 p <0.05, and positive correlation with anti-ds-DNA Ab, proteinuria 24h and Up/cre p <0.001.
 Conclusion: In our study, the biomarker u/NGAL, showed a statistically significant correlation with traditional parameters of lupus nephritis activity, and its determination could be significant in monitoring LN activity and monitoring responses to applied treatment.

Close association of systemic immune-inflammation index with hepatic steatosis than fibrosis: evidences from NHANES 1999–2018

“…In the study, SII was constructed to predict the recurrence and survival for hepatocellular carcinoma patients (7). In the recent years, more and more studies use SII to explore the association of systemic in ammation with the subjects' healthy status (lupus nephritis (21), psoriasis (22), arthritis (23) and NAFLD (19,24,25)). One study, based on NHANES, revealed that ln-transformed SII was an independent risk factor for NAFLD risk (de ned by a US Fatty Liver Index (USFLI) score exceeding 30), and the corresponding OR and 95%CI was 1.46 (1.27, 1.69) (24).…”

The significance of biomarkers of inflammation in predicting the activity of Lupus nephritis

“…Timely diagnosis and treatment of LN allow not only the recovery of kidney function but also prevent life-threatening complications. This is also the reason for many studies examining the role of various markers that would enable the diagnosis and monitoring of LN activity, the occurrence of potential relapses, and the right time to reduce the dose of immunosuppressive therapy [1] [2] [3] [4] [5] . Potential markers whose determination is not complicated, which do not require a long process, and are available in everyday clinical practice are significant.…”