Comparisons of focal macular electroretinograms after indocyanine green-, brilliant blue G-, or triamcinolone acetonide-assisted macular hole surgery

Machida, Shigeki; Nishimura, Tomoharu; Ohzeki, Takayuki; Murai, Kazuo; Kurosaka, Daijiro

doi:10.1007/s00417-016-3478-8

Cited by 24 publications

(9 citation statements)

References 30 publications

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“…88 However, a similar paper, reporting on 48 eyes of 48 patients with a macular hole in which, the same three agents were used (16 per agent) found no differences in focal macular electroretinogram outcomes between agents; it concluded that none of the three agents is toxic to the macula. 90 Triamcinolone acetonide has been safely used to visualize residual vitreous to facilitate removal of the ILM with good results and low concerns for toxicity. 76,80 Importantly, when the surgeon prefers ICG to stain the ILM, efforts should be made to avoid unnecessarily high concentrations of ICG or prolonged exposure.…”

Section: P189mentioning

confidence: 99%

Idiopathic Macular Hole Preferred Practice Pattern®

et al. 2020

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Section: P189mentioning

confidence: 99%

Idiopathic Macular Hole Preferred Practice Pattern®

et al. 2020

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“…По данным отечественной и зарубежной литературы, снижение функциональной активности нейронов сетчатки, в том числе её внутренних слоёв, объясняется наличием операционной травмы вследствие механического воздействия на сетчатку во время удаления патологических мембран [11]. В ряде других работ зарубежных коллег схожие изменения функциональной активности нейронов возникают вследствие химического воздействия искусственных красителей, контрастирующих патологические мембраны во время операции [12,13].…”

Section: таблица 2 / Tableunclassified

Retinal and optic nerve functional activity after vitrectomy for vitreomacular traction syndrome

Nikolaenko

Николаевна²,

Kulikov

et al. 2019

Ophthalmology Reports

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Background. Impacts of vitrectomy for vitreomacular traction syndrome on retinal and optic nerve functional activity are analyzed. Materials and methods. The electrophysiological monitoring was carried out before vitrectomy and on Days 1, 3, 7, 14, 30, 60, 180 after surgery in 59 patients (59 eyes). Patients were divided into three groups depending on the intraocular tamponade type: the first group air tamponade, the second group gas (C3F8) tamponade, the third group BSS (balanced salt solution). Results. A significant inhibition of the functional activity of neurons of internal layers of the retina and of the optic nerve was revealed on the Day 1 after surgery compared to baseline data (р 0.001). In groups I and III, the functional activity of inner layers of the retina and of the optic nerve restored twice as actively as that in the second group. Conclusions. Vitrectomy causes a reversible and significant inhibition of functional activity of retina and optic nerve. The duration of vitrectomy procedure is a significant negative factor determining the degree of depression of the functional activity of inner layers of the retina and of the optic nerve in the post-op period. The gas tamponade of the vitreous cavity with perfluoropropane-air mixture, compared to air and BSS tamponades, is a significant negative factor influencing the degree of functional activity inhibition of retina and optic nerve after surgery.

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“…Further, one electroretinogram and histopathology study used ICG, TA, and BBG in a pig eye model and reported that the cytotoxicity of ICG is significantly higher than that of TA or BBG [ 95 ]. Another experiment found that neither BBG nor TA use had a significant effect on postoperative mfERG (multifocal electroretinogram) responses or histology in pig eye [ 95 , 103 ]. A meta-analysis further showed that there is no significant difference in the rate of hole closure following MH surgery using BBG versus other dyes, but significantly better recovery of postoperative visual function was present when BBG was used compared to ICG or other dyes [ 104 ].…”

Section: The Surgical Techniquesmentioning

confidence: 99%

A Review of Surgical Outcomes and Advances for Macular Holes

Zhao

Wang

Liu

et al. 2018

Journal of Ophthalmology

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The surgical outcomes of macular holes (MHs) have improved greatly in recent years. The closure rate is as high as 90–100%, but the outcomes of some special types of MHs remain unsatisfactory. Internal limiting membrane (ILM) peeling dramatically improves the anatomic success rate, but recent studies have found that it could also cause mechanical and subclinical traumatic changes to the retina. Dyes are widely used, and apart from indocyanine green (ICG), the toxicities of other dyes require further research. Face-down posturing is necessary for MHs larger than 400 μm, and the duration of this posture is determined by the type of tamponade and the case. The ellipsoid zone has been shown to be highly correlated with visual outcome and recovery. New surgical methods include the inverted ILM flap technique and the ILM abrasion technique. However, they require further research to determine their effectiveness.

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Comparisons of focal macular electroretinograms after indocyanine green-, brilliant blue G-, or triamcinolone acetonide-assisted macular hole surgery

Abstract: The lack of significant differences on the different components of the fmERGs indicates that none of the three agents was toxic to the macula. After closure of a MH, the function of the retinal ganglion cells may recover more than that of the other neural elements in the macular area.

Cited by 24 publications

References 30 publications

Idiopathic Macular Hole Preferred Practice Pattern®

Idiopathic Macular Hole Preferred Practice Pattern®

Retinal and optic nerve functional activity after vitrectomy for vitreomacular traction syndrome

A Review of Surgical Outcomes and Advances for Macular Holes

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