Comparisons of the outcomes on control, type of management and complications status in early onset and late onset type 2 diabetes in Asia

Chuang, Lee‐Ming; Soegondo, Sidartawan; Soewondo, Pradana; Kim, Young-Seol; Mohamed, Mafauzy; Dalisay, Edith; Go, Ruby; Litsky, Warren; Tai, Tong-Yuan; Tandhanand, S; Nitiyanant, Wannee; The-Trach, Mai; Cockram, Clive S.; Jing-Ping, Yeo

doi:10.1016/j.diabres.2005.05.007

Cited by 49 publications

(25 citation statements)

References 20 publications

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“…This observation leads to the idea that treatment to suppress EGP and to improve first-phase insulin secretion would be most effective for Japanese patients with type 2 diabetes mellitus. The present study revealed that the age of diabetes onset was a significant predictor of glycemic control and that it was more difficult to stabilize glycemic control in youngeronset patients despite uniform protocol for treatment titration, consistent with previous work [19][20][21]. Elgzyri et al [22] followed more than a thousand type 2 diabetes mellitus patients for 7 years after diagnosis and demonstrated that age at diagnosis showed a significant influence on HbA 1c change over time.…”

Section: Discussionsupporting

confidence: 92%

Predictors of glycemic control in Japanese subjects with type 2 diabetes mellitus

Tokuyama

Ishizuka

Matsui³

et al. 2008

Metabolism

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Section: Discussionsupporting

confidence: 92%

Predictors of glycemic control in Japanese subjects with type 2 diabetes mellitus

Tokuyama

Ishizuka

Matsui³

et al. 2008

Metabolism

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“…As expected, the prevalence of vascular complications such as coronary heart disease and cerebrovascular disease increased with age and were higher than the general population without diabetes mellitus [22][23][24][25]. Studies have suggested that early onset T2DM was associated with an increased risk for complications compared with later onset diabetes [26] and that the development and progression of complications might be more rapid in early onset disease [27][28][29]. Song et al in 2009 reported that the management of risk factors for diabetes complications was inadequate among the early onset T2DM cohort and they were at substantial risk of developing diabetes complications in later years and at an earlier stage [30].…”

Section: Discussionmentioning

confidence: 74%

Association of Younger Age With Poor Glycemic and Cholesterol Control in Asians With Type 2 Diabetes Mellitus in Singapore

Toh

2011

J Endocrinol Metab

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Background: The prevalence of type 2 diabetes mellitus (T2DM) in children and adolescents is increasing in both poor and rich countries. Epidemiologic studies have reported significant and continuous associations between HbA1c level and diabetes-related vascular complications. Younger adults with early exposure to hyperglycemia are at high risk for end-organ damage. Few studies have reported the relationship of age to glycemic control in patients with T2DM world-wide and little comparison among young adults and elderly patients especially in the Asian population. This study investigates the relationship of age and glycemic control in Asian patients with T2DM attending primary care clinics in Singapore.

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“…These patients lose up to 15 years of life expectancy, which is two-fold greater than the number of years lost by patients with late-onset diabetes9. In contrast to late-onset diabetes, early-onset diabetes is associated with a higher risk of developing cardiovascular and microvascular complications, which are largely due to prolonged disease exposure in both Westerners and Asians381011. A large number of early-onset diabetes patients receive inadequate anti-glycaemic treatment and suboptimal cardio-protective treatment, which may be partially attributed to the lack of knowledge regarding the harm of early-onset diabetes in daily clinical practice312.…”

mentioning

confidence: 99%

The characteristics of newly diagnosed adult early-onset diabetes: a population-based cross-sectional study

Zou

Zhou

et al. 2017

Sci Rep

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To investigate the characteristics of newly diagnosed early-onset diabetes in the Chinese population, 2801 newly diagnosed diabetes participants without known diabetes or pre-diabetes in a national cross-sectional survey were analysed. Participants were divided into quartiles (22–43, 44–52, 53–61 and >61 years) according to age of diabetes onset and the first group were defined as early-onset diabetes group. Early-onset diabetes group had lower systolic blood pressure (SBP), total cholesterol, low density lipoprotein cholesterol, 2-hour post prandial blood glucose and urine albumin creatinine ratio. There was no difference in body mass index, Homeostasis model assessment (HOMA) of beta cell function and diabetes family history between early-onset diabetes participants and any other age groups. HOMA of insulin resistance (IR) scores and disposition index 30 minutes after glucose load (DI30) were increased in early-onset diabetes participants. The beta cell function declination was more deteriorated in early-onset diabetes participants. Male gender, triglycerides, HOMA-IR and DI30 were positively associated with an earlier age at diagnosis. In conclusion, patients diagnosed with diabetes at a younger age are characterized by a similar cardiovascular risk profile with increased insulin resistance and more severe beta cell failure than patients diagnosed at a later age.

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Comparisons of the outcomes on control, type of management and complications status in early onset and late onset type 2 diabetes in Asia

Cited by 49 publications

References 20 publications

Predictors of glycemic control in Japanese subjects with type 2 diabetes mellitus

Predictors of glycemic control in Japanese subjects with type 2 diabetes mellitus

Association of Younger Age With Poor Glycemic and Cholesterol Control in Asians With Type 2 Diabetes Mellitus in Singapore

The characteristics of newly diagnosed adult early-onset diabetes: a population-based cross-sectional study

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