Comparitive Antiobesity and Hypolipidemic Activity of Various Extracts of Tecoma gaudichaudi flowers in Monosodium Glutamate Dietary Model in Rats

Abstract

In the present study, we evaluated the antiobesity and hypolipidemic activities of ethanolic, ethyl acetate and hexane extracts of Tecoma gaudichaudi flowers in rat models.Anti-obesity activity of ethanolic, ethyl acetate and hexane extracts (200 & 400 mg/kg)of Tecoma gaudichaudi flowers were evaluated in rats fed with monosodium glutamate (8 mg/gm) diet. Experimental parameters like body weight, food consumption, locomotor behavior, serum glucose, triglyceride, total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) were studied for evaluating the anti-obesity activity of ethanolic extract (EE), ethyl acetate extract (EAE) and hexane extracts (HE) of Tecoma gaudichaudi flowers and orlistat (5mg/kg). There was a significant decrease of total cholesterol, total triglycerides and LDL-C and a significant increase of HDL-C level in hyperlipidemic rats after four-week administration of different extracts of Tecoma gaudichaudi flowers. Treatment with ethanolic extract (EE), ethyl acetate extract (EAE) and hexane extracts (HE) of Tecoma gaudichaudi exhibited antihyperlipidemic properties which might lead to improvement of serum lipid profile.