Compartmentalized bimetal cluster-poly(aniline) hybrid nanostructures for multiplexed detection of autoantibodies in early diagnosis of rheumatoid arthritis
“… Types of nanosensors Types of biomarkers Range and limit of detection Ref. Polyaniline-gold nanocomposite Anti-cyclic citrullinated peptide antibody (anti-CCP) The range of detection was 0.001 ng/ml to 15 ng/ml with a detection limit of 0.2 pg/ml [ 80 ] Au@Ag nanoparticles Human IgM The range of detection was 0.1 ng/ml to 10 μg/ml with a detection limit of 0.1 ng/ml [ 81 ] Gold nanoparticles IgM rheumatoid factor (RF) The range of detection was 1.6 IU/ml to 41.5 IU/ml with a detection limit of 4.15 IU/ml (clinical threshold is 20 IU/ml) [ 82 ] Gold nanoparticles A disintegrin and metalloproteinase with thrombospondin motif-4 (ADAMTS-4) The range of detection was 3.9 pM–250 pM with a detection limit of 1.1 pM [ 83 ] Gold nanoparticles Anti-interleukin-1β antibody The range of detection was 0.05 ng/ml to 10 ng/ml with a detection limit of 21 pg/ml [ 84 ] Organic–inorganic hybrid nanostructures Anti-CCP and RF IgM Multiplexing of anti-CCP and RF IgM was achieved in low concentration ranges, and their detection limits were 0.68 IU/ml and 0.93 IU/ml, respectively [ 85 ] Graphene Anti-CCP The range of detection was 1 fg/ml to 1 μg/ml with a detection limit of 10 fg/ml [ 36 ] …”
Section: Nanomaterials For Bone-related Disease Diagnosismentioning
“… Types of nanosensors Types of biomarkers Range and limit of detection Ref. Polyaniline-gold nanocomposite Anti-cyclic citrullinated peptide antibody (anti-CCP) The range of detection was 0.001 ng/ml to 15 ng/ml with a detection limit of 0.2 pg/ml [ 80 ] Au@Ag nanoparticles Human IgM The range of detection was 0.1 ng/ml to 10 μg/ml with a detection limit of 0.1 ng/ml [ 81 ] Gold nanoparticles IgM rheumatoid factor (RF) The range of detection was 1.6 IU/ml to 41.5 IU/ml with a detection limit of 4.15 IU/ml (clinical threshold is 20 IU/ml) [ 82 ] Gold nanoparticles A disintegrin and metalloproteinase with thrombospondin motif-4 (ADAMTS-4) The range of detection was 3.9 pM–250 pM with a detection limit of 1.1 pM [ 83 ] Gold nanoparticles Anti-interleukin-1β antibody The range of detection was 0.05 ng/ml to 10 ng/ml with a detection limit of 21 pg/ml [ 84 ] Organic–inorganic hybrid nanostructures Anti-CCP and RF IgM Multiplexing of anti-CCP and RF IgM was achieved in low concentration ranges, and their detection limits were 0.68 IU/ml and 0.93 IU/ml, respectively [ 85 ] Graphene Anti-CCP The range of detection was 1 fg/ml to 1 μg/ml with a detection limit of 10 fg/ml [ 36 ] …”
Section: Nanomaterials For Bone-related Disease Diagnosismentioning
“…In biological applications, organic–inorganic hybrid nanomaterials have been investigated because of their structural and compositional variations in each section. Due to its interparticle plasmonic pairing for photonics-based biosensor applications, a mixture of these hybrid NPs with metallic nanomaterial would be desirable [ 118 ]. Hwang et al [ 118 ] prepared silver/gold (Ag@Au) core–shell NPs)-poly(aniline) hybrid nanostructures (CBCPHNs) for the early diagnosis of RA.…”
Section: Nanomaterials For the Diagnosis Of Inflammatory Arthritismentioning
confidence: 99%
“…Due to its interparticle plasmonic pairing for photonics-based biosensor applications, a mixture of these hybrid NPs with metallic nanomaterial would be desirable [ 118 ]. Hwang et al [ 118 ] prepared silver/gold (Ag@Au) core–shell NPs)-poly(aniline) hybrid nanostructures (CBCPHNs) for the early diagnosis of RA. Nanohybrids were used in surface-enhanced Raman scattering (SERS)-based multiplexed detection of auto-antibodies (RF IgM and anti-CCP).…”
Section: Nanomaterials For the Diagnosis Of Inflammatory Arthritismentioning
Nanomaterials have received increasing attention due to their unique chemical and physical properties for the treatment of rheumatoid arthritis (RA), the most common complex multifactorial joint-associated autoimmune inflammatory disorder. RA is characterized by an inflammation of the synovium with increased production of proinflammatory cytokines (IL-1, IL-6, IL-8, and IL-10) and by the destruction of the articular cartilage and bone, and it is associated with the development of cardiovascular disorders such as heart attack and stroke. While a number of imaging tools allow for the monitoring and diagnosis of inflammatory arthritis, and despite ongoing work to enhance their sensitivity and precision, the proper assessment of RA remains difficult particularly in the early stages of the disease. Our goal here is to describe the benefits of applying various nanomaterials as next-generation RA imaging and detection tools using contrast agents and nanosensors and as improved drug delivery systems for the effective treatment of the disease.
“…The PANI hemisphere was modified with anti-CCP antibodies and rheumatoid factor immunoglobulin M. For the multiplexed assay, MB were modified with the same antibodies for the capture of RA autoantibodies, followed by tagging with the Au–Ag-PA Janus nanohybrids for subsequent SERS detection exploiting the Au and Ag NPs as hot-spots. Successful multiplexed detection of anti-CCP and rheumatoid factor immunoglobulin M was achieved with LOD of 0.7 and 0.9 IU/mL, respectively [ 53 ]. Fig.…”
Section: Sensing and Biosensing With Jps And Jmsmentioning
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