Compatibility and Stability of Ternary Admixtures of Tramadol, Haloperidol, and Hyoscine<i>N</i>-Butyl Bromide: Retrospective Clinical Evaluation

Negro, Sofı́a; Martín, Alicia; Azuara, Luz; Sánchez, Yolanda; Barcia, Emilia

doi:10.1089/jpm.2009.0187

Cited by 11 publications

(9 citation statements)

References 20 publications

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“…Local injection techniques are one of those methods. In this technique, local anesthetics and weak opioids, like tramadol, have been examined [8][9][10][11][12][13]. Tramadol is a medicine with central effect, which has been effective in reduction of moderate and severe pains.…”

Section: Introductionmentioning

confidence: 99%

“…Tramadol is a medicine with central effect, which has been effective in reduction of moderate and severe pains. In clinical and laboratory studies, its local analgesic and anesthetic, in addition to its systemic, effects on peripheral nerves and spinal cord have been proven [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. Tramadol is well tolerated by patients.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Local Tramadol Injection in Post Appendectomy Pain

Khazaei

Kalati

Borumand

et al. 2015

Zahedan J Res Med Sci

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Background: Tramadol is a weak synthetic opioid with an effective analgesic result. This medicine has both systemic and local anesthetic effects on peripheral nerve system. Objectives: The purpose of this study is to compare post-appendectomy analgesic effect of subcutaneous injection of tramadol with normal saline. Patients and Methods: This double blind study was conducted on 60 patients over 15 years old, who were randomly divided in two equal groups, i.e. tramadol and normal saline. After repairing fascia in appendectomy, 100 mg of tramadol that was diluted up to 10 mL and 10 mL normal saline were used for subcutaneously injection around the surgical wound in experimental and control groups, respectively. Then, the intensity of pain was recorded in the recovery room, and 6 and 24 hours after operation, based on NRS. In addition, number of petidine (with a dosage of 25 milligram) administered in the same period, in case of severe and moderate pain, was recorded. At the end, the intensity of pain during the mentioned time and the average use of petidine in two groups were compared. Results: The average of severe pain in recovery time (3.08 ± 1.44 versus 5.36 ± 2.02), 6 (3.36 ± 1.22 versus 5.36 ± 1.38) and 12 (2.08 ± 0.76 versus 3.08 ± 1.15) hours after operation was lower in tramadol group (P = 0.0001). Moreover, the amount of consumed petidine in the same period of time showed a clear reduction (P < 0.05). Conclusions: Subcutaneous injection of tramadol is an appropriate choice for reduction of post-appendectomy pain and decreasing need for potent narcotic painkillers. This treatment method can decrease side effects of using potent narcotics after appendectomy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effect of Local Tramadol Injection in Post Appendectomy Pain

Khazaei

Kalati

Borumand

et al. 2015

Zahedan J Res Med Sci

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“…Of the included sources, 57.9% (n = 33/57) were of European origin. Almost half and thus the majority of the European sources (48.5%, n = 16/33) originated from the United Kingdom [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] followed by Spain (n = 7/33, 21.2%), [38][39][40][41][42][43][44] France, [45][46][47] and Germany [48][49][50] (both with n = 3/33, 9.1% each). Other represented countries were Denmark, 51 Italy, 52 Portugal, 53 and Norway, 54 each contributing one source.…”

Section: Characteristics Of Sources Of Evidencementioning

confidence: 99%

Subcutaneous Drugs and Off-label Use in Hospice and Palliative Care: A Scoping Review

Wernli

Dürr

Jean-Petit-Matile³

et al. 2022

Journal of Pain and Symptom Management

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“…The stability of this drug has been studied in 5% dextrose,17 and in admixtures has been previously described with tramadol,8 diamorphine hydrochloride18 and scopolamine N-butyl bromide 5. Also, the compatibility of tertiary blends with haloperidol, tramadol and dexketoprofen,19 or haloperidol, tramadol and hyoscine,20 has been analysed.…”

Section: Introductionmentioning

confidence: 99%

Stability of mixtures of ondansetron and haloperidol stored in infusors at different temperatures

2018

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Background and objectiveMixing different drugs for use in continuous infusion systems is a common practice in palliative care, but analytical study of compatibility and stability is not always available. The objective of this work is to study the stability of solutions of ondansetron and haloperidol at different concentrations and temperatures all prepared in 0.9% NaCl and stored in infusors, with all cases protected from light.Materials and methodsThe high performance liquid chromatography-Ultraviolet (HPLC-UV) method was employed for the determination of the drugs. The concentrations of the admixtures were 0.15–0.25 mg/mL and 0.3–0.4 mg/mL of haloperidol and ondansetron, respectively, with a storage temperature of 25°C and 37°C.ResultsAll solutions were initially clear and colourless, but visible particles appear, in all cases, into the infusers after 2 days since their preparation.ConclusionFrom the results obtained we can conclude that the mixtures prepared in the conditions previously described are stable less than 48 hours.

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Compatibility and Stability of Ternary Admixtures of Tramadol, Haloperidol, and HyoscineN-Butyl Bromide: Retrospective Clinical Evaluation

Abstract: Our results confirm the compatibility and stability of the ternary admixture and its utility in highly vulnerable patients exhibiting moderate symptoms.

Cited by 11 publications

References 20 publications

The Effect of Local Tramadol Injection in Post Appendectomy Pain

The Effect of Local Tramadol Injection in Post Appendectomy Pain

Subcutaneous Drugs and Off-label Use in Hospice and Palliative Care: A Scoping Review

Stability of mixtures of ondansetron and haloperidol stored in infusors at different temperatures

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