Stability of mixtures of ondansetron and haloperidol stored in infusors at different temperatures

Espinosa-Bosch, M; Rojas, F. Sánchez; Ojeda, C. Bosch

doi:10.1136/ejhpharm-2017-001412

Cited by 4 publications

(5 citation statements)

References 19 publications

(8 reference statements)

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“…The stress sensitivity of both pure drug and drug in PN admixture is confirmed by other studies. OND is susceptible to oxidation and acid/basic hydrolysis, while it remains insensitive to decomposition under the influence of temperature at the boiling point [23,31].…”

Section: Discussionmentioning

confidence: 99%

“…Chen et al [24] developed and validated the HPLC-DAD (diode array detector) method for the simultaneous quantification of dexamethasone sodium phosphate, OND, granisetron, tropisetron, and azasetron hydrochlorides in infusion samples. Espinosa-Bosch et al [31] evaluated the stability and the compatibility of haloperidol and OND when stored in elastomeric infusors at two temperatures (25 and 37 • C). In 1995, Kirkham et al [32] described determination of OND in PN admixtures, but in their paper, no details are stated about sample isolation and method validation.…”

Section: Introductionmentioning

confidence: 99%

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Application of the HPLC Method in Parenteral Nutrition Assessment: Stability Studies of Ondansetron

et al. 2021

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Ondansetron (OND) is a serotonin type 3 receptor antagonist that exhibits antiemetic activity. From the clinical point of view, vomiting and nausea prevention is an important task. Anticancer treatment and recovery impact the patient’s overall state by affecting appetite, well-being, and physical activity, and consequently, nutrition quality. Depending on the patient’s indication and condition, parenteral nutrition is administered to meet full nutritional requirements. In addition, antiemetic drugs can be added to the parenteral nutrition (PN) admixture to treat chemo- or radio-therapy-induced nausea and vomiting. However, adding any medication to the PN admixture can result in the instability of the composition in the overall admixture. This study aimed to develop the HPLC method of determination of OND in Lipoflex special, one of the most popular, ready-to-use PN admixtures. The proposed HPLC method and the sample preparation procedure were suitable for analyzing OND in PN admixture stored under various conditions, such as exposure to sunlight and temperature. It was found that the decomposition of OND during the seven-day storage did not exceed 5% and did not depend on external factors. Based on the conducted research, it is recommended to add OND to Lipoflex special, and it is possible to store such an admixture for seven days.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Application of the HPLC Method in Parenteral Nutrition Assessment: Stability Studies of Ondansetron

et al. 2021

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“…It was shown that levomepromazine decomposed fastest in a 0.9% NaCl solution, and the storage of morphine at 4 • C led to its precipitation [42]. Espinosa-Boch et al evaluated the stability of mixtures of haloperidol and ondansetron stored at various temperatures, confirming their stability up to 48 h after preparation [43].…”

Section: Introductionmentioning

confidence: 99%

Stability Study of Selected Coxibs Used in the Treatment of Rheumatoid Diseases in Various Drug Combinations

Gumułka,

Dąbrowska,

Starek

2023

Processes

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Coxibs are a group of non-steroidal anti-inflammatory drugs (NSAIDs), selective cyclooxygenase 2 inhibitors, characterized by a much lower gastrotoxicity compared to classic NSAIDs. They are often used in conjunction with other drugs, which greatly increases the likelihood of adverse drug interactions. The presented study analyzed the degradation rate of celecoxib and cimicoxib in solutions under the influence of other medicinal substances at different temperatures. For this purpose, triple-drug mixtures were prepared, consisting of coxib and eleven different commonly used drugs (paracetamol, ketoprofen, diclofenac, acetylsalicylic acid, ibuprofen, meloxicam, tramadol, doxycycline, bisoprolol, and caffeine). Then, the mixtures were incubated at two temperatures. Within the time specified by the research plan, further aliquots of the mixtures were subjected to a chromatographic analysis. Separation was conducted on HPTLC F254 silica gel chromatographic plates as a stationary phase, using chloroform: acetone: toluene as a mobile phase, and was detected densitometrically at wavelengths of 254 nm. The percentage changes in the tested coxibs content, depending on the time and conditions of incubation, were presented. Based on the obtained data, the basic kinetic parameters of the degradation processes were determined. The celecoxib and cimicoxib showed a relatively high durability in changing environmental conditions. It was observed that the rate of decomposition of cimicoxib and celecoxib in the tested mixtures was different and depended on the temperature and presence of other components, with cimicoxib turning out to be a more stable compound.

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“…The antiemetic activity of the drug is brought about through the inhibition of 5-HT3 receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). This inhibition of 5-HT3 receptors in turn inhibits the visceral afferent stimulation of the vomiting center, likely indirectly at the level of the area postrema, as well as through direct inhibition of serotonin activity within the area postrema and the chemoreceptor trigger zone [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Stability of Binary Mixtures of Drugs at Different Concentrations and Temperatures

Fuensanta¹

2022

J Pharm Res Sci Technol

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Background and Objective: In order to avoid separate injections, admixtures of drugs are frequently used in palliative care setting. The objective of this work is to study the stability of binary mixtures of drugs (ondansetron and midazolam) at different concentrations and temperatures all prepared in 0.9% NaCl and stored into infusers and glass in all cases protected from light. Materials and Methods: Two methods have been employed to determine periodically the concentration of each drug in the mixtures (HPLC-UV and UV-vis spectrophotometry methods). The concentrations of the samples were: 0.1 mg mL-1 – 0.1 mg mL-1 and 0.5 mg mL-1 – 1.0 mg mL-1 of ondansetron and midazolam respectively; temperature of storage 25ºC and 37ºC. NaCl 0.9% was used as diluent in all cases. The containers to store each mixture were three infusers and glass. Results: All solutions were initially clear and colourless but visible particles appear, in all cases, into the infusers after two days since their preparation. Conclusions: The admixture of ondansetron and midazolam in NaCl 0.9% is recommended to use for a maximum of one day, at the concentrations evaluated, over time it tends to precipitate. Infuser conditioning decreases stability with respect to other conditions materials, so other stability studies may not be extrapolated if stored under different conditions.

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Stability of mixtures of ondansetron and haloperidol stored in infusors at different temperatures

Cited by 4 publications

References 19 publications

Application of the HPLC Method in Parenteral Nutrition Assessment: Stability Studies of Ondansetron

Application of the HPLC Method in Parenteral Nutrition Assessment: Stability Studies of Ondansetron

Stability Study of Selected Coxibs Used in the Treatment of Rheumatoid Diseases in Various Drug Combinations

Stability of Binary Mixtures of Drugs at Different Concentrations and Temperatures

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