Compatibility of ciprofloxacin injection with selected drugs and solutions

A rapid, simple, and sensitive immunochromatographic test strip has been developed for testing residues of ciprofloxacin (CIP). A specific and sensitive monoclonal antibody (mAb) for CIP was generated by immunizing BALB/c mice with well-characterized CIP-Keyhole limpet haemocyanin. Under the optimized conditions, the cut-off limits of test strips for CIP were found to be 5 ng/mL in phosphate-buffered saline and 2.5 ng/mL in milk samples. Each test can be evaluated within 3 min. The cross-reactivities of the CIP test strip to enrofloxacin (ENR), norfloxacin (NOR), nadifloxacin (NDF), danofloxacin (DANO), pefloxacin (PEX), lomefloxacin (LOME), enoxacin (ENO), and sarafloxacin (SAR) were 71.4%, 71.4%, 66%, 50%, 33%, 20%, 12.5%, and 6.25%, respectively. The data indicate that the method is sensitive, specific, and has the advantages of simplicity and speed, therefore, this test strip is a useful screening method for the detection of CIP residues in milk samples.

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Compatibility of ciprofloxacin injection with selected drugs and solutions

Cited by 3 publications

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Stability and compatibility studies of pefloxacin, ofloxacin and ciprofloxacin with PVC infusion bags

Stability and compatibility studies of pefloxacin, ofloxacin and ciprofloxacin with PVC infusion bags

Stability and compatibility of admixtures of intravenous ciprofloxacin and selected drugs

Development of an Immunochromatographic Strip Test for Rapid Detection of Ciprofloxacin in Milk Samples

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