Compatibility studies of nevirapine in physical mixtures with excipients for oral HAART

Oliveira, George Gualberto Gualter de; Ferraz, Humberto Gomes; Severino, Patrícia; Souto, Eliana B.

doi:10.1016/j.msec.2012.09.030

Cited by 7 publications

(2 citation statements)

References 34 publications

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“…The development of a new pharmaceutical dosage form involves preliminary pre-formulation studies for which information about the physical, chemical and mechanical properties of the formulation constituents is necessary. Mixture of drug/excipient can affect the long-term stability of the solid dosage form, as well as the drug bioavailability, therapeutic efficiency and safety profile (de Oliveira et al, 2013b, de Oliveira et al, 2011). In addition, the interactions between drug and excipients can affect the quality of the mixture, including the polymorphic form and crystallization profile of the drug, but also the formulation properties such as the solubility of the mixture, color, odor, and taste (Wu et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Compatibility study of paracetamol, chlorpheniramine maleate and phenylephrine hydrochloride in physical mixtures

Oliveira

Feitosa

Loureiro

et al. 2017

Saudi Pharmaceutical Journal

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Paracetamol (PAR), phenylephrine hydrochloride (PHE) and chlorpheniramine maleate (CPM) are commonly used in clinical practice as antipyretic and analgesic drugs to ameliorate pain and fever in cold and flu conditions. The present work describes the use of thermal analysis for the characterization of the physicochemical compatibility between drugs and excipients during the development of solid dosage forms. Thermogravimetric analysis (TGA) and Differential Scanning Calorimetry (DSC) were used to study the thermal stability of the drug and of the physical mixture (drug/excipients) in solid binary mixtures (1:1). DSC thermograms demonstrated reproducible melting event of the prepared physical mixture. Starch, mannitol, lactose and magnesium stearate influence thermal parameters. Information recorded from the derivative thermogravimetric (DTG) and TGA curves demonstrated the decomposition of drugs in well-defined thermal events, translating the suitability of these techniques for the characterization of the drug/excipients interactions.

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Section: Introductionmentioning

confidence: 99%

Compatibility study of paracetamol, chlorpheniramine maleate and phenylephrine hydrochloride in physical mixtures

Oliveira

Feitosa

Loureiro

et al. 2017

Saudi Pharmaceutical Journal

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“…The study for the interactions was performed by using a physical mixture of rivaroxaban and excipients of equal proportions (1:1 W/W). The mixtures were prepared by simple mixing using the mortar and pestle, weighed for the required quantity, and were sealed in the aluminium pans for the analysis 9,10 .…”

Section: Preparation Of Physical Mixturesmentioning

confidence: 99%

Physico-Chemical Characterization of Rivaroxaban and Compatibility Studies with Its Pharmaceutical Excipients

Nadendla

Juluri

Doppalapudi

et al. 2021

Int J Life Sci Pharm Res

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Physico-chemical compatibility studies were performed to check the effect of different excipients on API and it is the prerequisite in the preformulation studies. The main aim of this research is to study the behavior of the API individually and with the selected pharmaceutical excipients which mainly contribute in the selection of suitable excipients for developing an ideal dosage form. Rivaroxaban is an oral anticoagulant that mainly acts by blocking coagulant factor Xa. Incompatibility studies were performed for rivaroxaban with selected pharmaceutical excipients like HPMC, lactose, magnesium stearate, sodium lauryl sulfate, microcrystalline cellulose, croscarmellose sodium, HPC using the Scanning electron microscopy, X-ray powder diffraction and differential scanning calorimeter. A 1:1 physical mixture of rivaroxaban and selected excipient was analysed using differential scanning calorimeter. Rivaroxaban showed the transition at 231.79 0C with 114.2J/g specific heat of fusion. The transition temperature of rivaroxaban has not changed much when compared with the combination of rivaroxaban with excipients. The 2θ values of the standard drug were compared with the spectrum obtained from the XRD study. This comparison showed that there was no evidence regarding the incompatibility of the drug with excipients. The photomicrographs obtained by SEM did not showed any interaction between rivaroxaban and the excipients, providing visual support for the results.

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Photocatalytic degradation of nevirapine with a heterostructure of few-layer black phosphorus coupled with niobium (V) oxide nanoflowers (FL-BP@Nb2O5)

et al. 2020

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Compatibility studies of nevirapine in physical mixtures with excipients for oral HAART

Cited by 7 publications

References 34 publications

Compatibility study of paracetamol, chlorpheniramine maleate and phenylephrine hydrochloride in physical mixtures

Compatibility study of paracetamol, chlorpheniramine maleate and phenylephrine hydrochloride in physical mixtures

Physico-Chemical Characterization of Rivaroxaban and Compatibility Studies with Its Pharmaceutical Excipients

Photocatalytic degradation of nevirapine with a heterostructure of few-layer black phosphorus coupled with niobium (V) oxide nanoflowers (FL-BP@Nb2O5)

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