Compensatory proliferation and apoptosis-induced proliferation: a need for clarification

Mollereau, Bertrand; Pérez-Garijo, Ainhoa; Bergmann, Andreas; Miura, Masayuki; Gerlitz, Offer; Ryoo, Hyung Don; Steller, Hermann; Morata, Ginés

doi:10.1038/cdd.2012.82

Cited by 99 publications

(84 citation statements)

References 8 publications

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“…However, the signals that trigger the downregulation of Notch after HC death remain elusive. Studies in other organ systems and animals have shown that apoptosis initiates cell proliferation in neighboring cells to promote tissue repair, a process called compensatory proliferation [64,65]. We propose that an analogous process might occur during HC regeneration.…”

Section: Identifying New Molecules/pathways Important For Hair Cell Rmentioning

confidence: 84%

Insights into sensory hair cell regeneration from the zebrafish lateral line

Kniss

Jiang

Piotrowski

2016

Current Opinion in Genetics & Development

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Section: Identifying New Molecules/pathways Important For Hair Cell Rmentioning

confidence: 84%

Insights into sensory hair cell regeneration from the zebrafish lateral line

Kniss

Jiang

Piotrowski

2016

Current Opinion in Genetics & Development

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“…In the past few years, studies from metazoan models, such as Drosophila, forged the concept of apoptosis-induced proliferation, a process by which damaged cells entering apoptosis signal the surrounding unaffected cells to divide so as to recoup the tissue loss. 1,2,3 Using Drosophila developing imaginal discs as a model, several groups have demonstrated that fly wing imaginal discs submitted to g-irradiation or genetically induced cell death undergo apoptosis-induced proliferation. 4,5 Apoptosis-induced proliferation requires Drosophila p53 and the caspase Dronc, and involves the release of mitogens such as Wingless (Wg) and Decapentaplegic (Dpp) that induce the growth of the surrounding tissues.…”

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confidence: 99%

Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation

Dichtel-Danjoy

Dourlen

et al. 2012

Cell Death Differ

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Irradiated or injured cells enter apoptosis, and in turn, promote proliferation of surrounding unaffected cells. In Drosophila, apoptotic cells have an active role in proliferation, where the caspase Dronc and p53 induce mitogen expression and growth in the surrounding tissues. The Drosophila p53 gene structure is conserved and encodes at least two protein isoforms: a full-length isoform (Dp53) and an N-terminally truncated isoform (DΔNp53). Historically, DΔNp53 was the first p53 isoform identified and was thought to be responsible for all p53 biological activities. It was shown that DΔNp53 induces apoptosis by inducing the expression of IAP antagonists, such as Reaper. Here we investigated the roles of Dp53 and DΔNp53 in apoptosis and apoptosis-induced proliferation. We found that both isoforms were capable of activating apoptosis, but that they each induced distinct IAP antagonists. Expression of DΔNp53 induced Wingless (Wg) expression and enhanced proliferation in both 'undead cells' and in 'genuine' apoptotic cells. In contrast to DΔNp53, Dp53 did not induce Wg expression in the absence of the endogenous p53 gene. Thus, we propose that DΔNp53 is the main isoform that regulates apoptosis-induced proliferation. Understanding the roles of Drosophila p53 isoforms in apoptosis and in apoptosis-induced proliferation may shed new light on the roles of p53 isoforms in humans, with important implications in cancer biology

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“…This mechanism has been termed apoptosisinduced proliferation (AiP). 49 Because all current experimental models of CP involve the death of cells, it is possible that all of them act through AiP, though this is not yet demonstrated. When such dying cells are kept alive by blocking completion of apoptosis, generating ''undead'' cells, the result is overgrowth of the surrounding tissue, rather than re-establishment of proper tissue size and shape.…”

Section: Compensatory Proliferationmentioning

confidence: 98%

“…Some definitions of CP include mass ablation of tissue as described earlier. 49 However, the physical and molecular responses to the loss of large contiguous areas of tissue compared with loss of individual cells or small groups of cells are sufficiently different in that it is helpful to discuss them separately.…”

Section: Compensatory Proliferationmentioning

confidence: 99%

DrosophilaImaginal Discs as a Model of Epithelial Wound Repair and Regeneration

Smith-Bolton

2016

Advances in Wound Care

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The larval imaginal discs, which form the adult fly during metamorphosis, are an established model system for the study of epithelial tissue damage. The disc proper is a simple columnar epithelium, but it contains complex patterning and cell-fate specification, and is genetically tractable. These features enable unbiased genetic screens to identify genes involved in all aspects of the wound response, from sensing damage to wound closure, initiation of regeneration, and re-establishment of proper cell fates. Identification of the genes that facilitate epithelial wound closure and regeneration will enable development of more sophisticated wound treatments for clinical use. Imaginal disc epithelia can be damaged in many different ways, including fragmentation, induction of cell death, and irradiation. Recent work has demonstrated that the tissue's response to damage varies depending on how the wound was induced. Here, we summarize the different responses activated in these epithelial tissues after the different types of damage. These studies highlight that not all wounds elicit the same response from the surrounding tissue. A complete understanding of the various wound-healing mechanisms in will be a first step in understanding how to manage damaged human tissues and optimize healing in different clinical contexts. Further work is necessary to understand the similarities and differences among an epithelial tissue's responses to different insults. Ongoing studies will identify the genes and pathways employed by injured imaginal discs. Thus, work in this genetically tractable system complements work in more conventional wound-healing models.

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Compensatory proliferation and apoptosis-induced proliferation: a need for clarification

Cited by 99 publications

References 8 publications

Insights into sensory hair cell regeneration from the zebrafish lateral line

Insights into sensory hair cell regeneration from the zebrafish lateral line

Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation

DrosophilaImaginal Discs as a Model of Epithelial Wound Repair and Regeneration

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