Competing causes of death in the head and neck cancer population

Massa, Sean T.; Osazuwa-Peters, Nosayaba; Christopher, Kara M.; Arnold, Lauren D.; Schootman, Mario; Walker, Rebecca; Varvares, Mark A.

doi:10.1016/j.oraloncology.2016.12.006

Cited by 79 publications

(81 citation statements)

References 42 publications

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“…Four patients in our study died of a second primary malignancy; Cooper et al found that 10% of patients with head and neck cancer develop a second tumor within 3 years of RT . Massa et al found that 1 in 3 patients with head and neck cancer died of non‐head and neck cancer‐related causes, most commonly cardiovascular disease and other cancers . Other studies have found that patients diagnosed with cancer have an increased risk of cardiac death .…”

Section: Discussionmentioning

confidence: 46%

Early (90‐day) mortality after radical radiotherapy for head and neck squamous cell carcinoma: A population‐based analysis

et al. 2018

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Background A retrospective, population‐based analysis of 90‐day mortality in patients with squamous cell carcinoma of the head and neck treated with radiotherapy was performed to determine the early mortality rate and associated risk factors. Methods Data were abstracted for all consecutive patients with cancer of the head and neck treated from 1998 to 2014 at the BC Cancer Agency with curative intent radiotherapy (n = 5658). Logistic regression analysis was used to determine factors associated with early mortality. Results The median age at diagnosis was 63 years. The mortality rate at 90 days after starting radiotherapy (RT) was 3.6% (n = 203/5658). The cause of death was attributed to head and neck cancer for 81% of patients. Multivariate analysis demonstrated that increasing age, oral cavity subsite, and advanced T and N classification were associated with an increased risk of early mortality (p < .05). Conclusions The risk of early mortality was 3.6%. Elderly patients with advanced T and N classification had the highest risk of early mortality.

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Section: Discussionmentioning

confidence: 46%

Early (90‐day) mortality after radical radiotherapy for head and neck squamous cell carcinoma: A population‐based analysis

et al. 2018

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“…Unlike the younger cohort, whose mortality was almost entirely attributable to their cancer diagnosis, elderly patients have higher overall mortality rates and are at risk for dying of multiple causes. All HNSCC patients suffer from a higher noncancer mortality rate than the general population, but this risk is accentuated in the elderly . Yet even 10 years after a cancer diagnosis, the elderly patients are more likely to have died of their index cancer than all other causes.…”

Section: Discussionmentioning

confidence: 99%

Demographic predictors of head and neck cancer survival differ in the elderly

et al. 2018

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“…Postdiagnosis, they face persistent and late effects of their diagnosis and treatment, such as functional and esthetic compromise; [5][6][7][8] however, these effects are often overshadowed by the need to be cured or to survive. [10][11][12][13][14][15] Suicide rates have increased in the United States population since 1999, 16 yet the suicide rate is greater among cancer survivors than among survivors of other chronic diseases and the general population. [10][11][12][13][14][15] Suicide rates have increased in the United States population since 1999, 16 yet the suicide rate is greater among cancer survivors than among survivors of other chronic diseases and the general population.…”

Section: Introductionmentioning

confidence: 99%

Suicide risk among cancer survivors: Head and neck versus other cancers

Osazuwa‐Peters¹,

Zhao

Olomukoro

et al. 2018

Cancer

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BACKGROUND: Cancer survivors face psychosocial issues that increase their risk of suicide. This study examined the risk of suicide across cancer sites, with a focus on survivors of head and neck cancer (HNC). METHODS: The Surveillance, Epidemiology, and End Results 18-registry database (from 2000 to 2014) was queried for the top 20 cancer sites in the database, including HNC. The outcome of interest was suicide as a cause of death. The mortality rate from suicide was estimated for HNC sites and was compared with rates for 19 other cancer sites that were included in the study. Poisson regression was used to estimate adjusted rate ratios (aRRs) and 95% confidence intervals (CIs) for 1) HNC versus non-HNC sites (the other 19 cancer sites combined), and 2) HNC versus each individual cancer site. Models were stratified by sex, controlling for race, marital status, age, year, and stage at diagnosis. RESULTS: There were 404 suicides among 151,167 HNC survivors from 2000 to 2014, yielding a suicide rate of 63.4 suicides per 100,000 person-years. In this timeframe, there were 4493 suicides observed among 4219,097 cancer survivors in the study sample, yielding an incidence rate of 23.6 suicides per 100,000 person-years. Compared with survivors of other cancers, survivors of HNC were almost 2 times more likely to die from suicide (aRR, 1.97; 95% CI,). There was a 27% increase in the risk of suicide among HNC survivors during the period from 2010 to 2014 (aRR, 1.27; 95% CI, 1.16-1.38) compared with the period from 2000 to 2004. CONCLUSIONS: Although survival rates in cancer have improved because of improved treatments, the risk of death by suicide remains a problem for cancer survivors, particularly those with HNC. Cancer 2018;124:4072-4079.

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Competing causes of death in the head and neck cancer population

Cited by 79 publications

References 42 publications

Early (90‐day) mortality after radical radiotherapy for head and neck squamous cell carcinoma: A population‐based analysis

Early (90‐day) mortality after radical radiotherapy for head and neck squamous cell carcinoma: A population‐based analysis

Demographic predictors of head and neck cancer survival differ in the elderly

Suicide risk among cancer survivors: Head and neck versus other cancers

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